Neurobehavioral sequelae of traumatic brain injury

Riggio, Silvana; Wong, Meredith

doi:10.1002/msj.20097

Cited by 106 publications

(60 citation statements)

References 57 publications

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“…These health effects can persist and contribute to potential impairment, functional limitation, disability, and reduced quality of life (Riggio and Wong, 2009;Walker and Pickett, 2007). Disturbed cognition is the hallmark symptom of TBI but the injury also can affect behavior, emotion, and motor function.…”

Section: Tbi Health Effectsmentioning

confidence: 99%

“…Source: Brasure et al, 2012 Health and Other Effects of TBI TBIs can lead to a spectrum of secondary conditions that might result in long-term impairment, functional limitation, disability, and reduced quality of life. Health effects associated with TBI can be broadly categorized into cognitive, behavioral/emotional, motor, and somatic symptoms (Riggio and Wong, 2009;Walker and Pickett, 2007). Given the high frequency of frontal lobe injury, cognitive impairment is the hallmark injury of TBI; however, combinations of these health effects are frequently experienced.…”

Section: Characteristics Of Tbimentioning

confidence: 99%

“…However, gainful employment for a person affected by TBI has positively influenced outcomes and contributed to self-reported life satisfaction (Corrigan, Bogner, Mysiw, Clinchot, and Fugate, 2001). Anstey et al, 2004;Asikainen, Kaste, and Sarna, 1999;Clinchot, Bogner, Mysiw, Fugate, and Corrigan, 1998;Dikmen, Machamer, Fann, and Temkin, 2010;Granacher, 2005;Katz, White, Alexander, and Klein, 2004;Meares et al, 2011;Orff, Ayalon, and Drummond, 2009;Riemann and Guskiewicz, 2000;Riggio and Wong, 2009;Rogers and Read, 2007;Schmidt, Register-Mihalik, Mihalik, Kerr, and Guskiewicz, 2012;Silver et al, 2011;Williams, Morris, Schache, and McCrory, 2009;Ziino and Ponsford, 2006;Nampiaparampi, 2008. (Faul et al, 2010).…”

Section: Characteristics Of Tbimentioning

confidence: 99%

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Prospective study of myelin water fraction changes after mild traumatic brain injury in collegiate contact sports

Spader

Dean

LaFrance

et al. 2019

Journal of Neurosurgery

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OBJECTIVEMild traumatic brain injury (mTBI) in athletes, including concussion, is increasingly being found to have long-term sequelae. Current imaging techniques have not been able to identify early damage caused by mTBI that is predictive of long-term symptoms or chronic traumatic encephalopathy. In this preliminary feasibility study, the authors investigated the use of an emerging magnetic resonance imaging (MRI) technique, multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT), in visualizing acute and chronic white matter changes after mTBI in collegiate football and rugby players.METHODSThis study was a nonrandomized, nonblinded prospective trial designed to quantify changes in the myelin water fraction (MWF), used as a surrogate MRI measure of myelin content, in a group of male collegiate football and rugby players, classified here as a contact sport player (CSP) cohort, at the time of mTBI diagnosis and 3 months after injury when the acute symptoms of the injury had resolved. In addition, differences in the MWF between the CSP cohort and a control cohort of noncontact sport players (NCSPs) were quantified. T-tests and a threshold-free cluster enhancement (TFCE) statistical analysis technique were used to identify brain structures with significant changes in the MWF between the CSP and NCSP cohorts and between immediately postinjury and follow-up images obtained in the CSP cohort.RESULTSBrain MR images of 12 right-handed male CSPs were analyzed and compared with brain images of 10 right-handed male NCSPs from the same institution. A comparison of CSP and NCSP baseline images using TFCE showed significantly higher MWFs in the bilateral basal ganglia, anterior and posterior corpora callosa, left corticospinal tract, and left anterior and superior temporal lobe (p < 0.05). At the 3-month follow-up examination, images from the CSP cohort still showed significantly higher MWFs than those identified on baseline images from the NCSP cohort in the bilateral basal ganglia, anterior and posterior corpora callosa, and left anterior temporal lobe, and also in the bilateral corticospinal tracts, parahippocampal gyrus, and bilateral juxtapositional (previously known as supplemental motor) areas (p < 0.05). In the CSP cohort, a t-test comparing the MWF at the time of injury and 3 months later showed a significant increase in the overall MWF at follow-up (p < 0.005). These increases were greatest in the bilateral basal ganglia and deep white matter. MWF decreases were seen in more superficial white matter (p < 0.005).CONCLUSIONSIn this preliminary study, MWF was found to be increased in the brains of CSPs compared with the brains of controls, suggesting acute/chronic MWF alterations in CSPs from previous injuries. Increases in the MWF were also demonstrated in the brains of CSPs 3 months after the players sustained an mTBI. The full clinical significance of an increased MWF and whether this reflects axon neuropathology or disorderly remyelination leading to hypermyelination has yet to be determined.

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Section: Tbi Health Effectsmentioning

confidence: 99%

Section: Characteristics Of Tbimentioning

confidence: 99%

Section: Characteristics Of Tbimentioning

confidence: 99%

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Prospective study of myelin water fraction changes after mild traumatic brain injury in collegiate contact sports

Spader

Dean

LaFrance

et al. 2019

Journal of Neurosurgery

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“…A variety of terms have been used to describe these behavioural changes. [5][6][7][8][9] Descriptions in the literature pertaining to TBI include variations of "neurobehavioral symptoms", 5 "neuropsychatric consequences" 6 as well as standard definitions of psychiatric disorders (e.g. according to Diagnostic System Manual DSM 10 or International Classification of Disease ICD criteria), 11 applied to patients after traumatic brain injury.…”

Section: Introductionmentioning

confidence: 99%

Behavioural problems in the first year after Severe traumatic brain injury: a prospective multicentre study

et al. 2016

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Objective: To investigate the occurrence of behavioural problems in patients with severe traumatic brain injury during the first year after injury and potential associations with outcome. An additional post hoc objective was to analyse the frequency of behaviours with need for intervention from staff. Design and setting: In a prospective population based cohort study 114 patients with severe traumatic brain injury were assessed at three weeks, three months and one year after injury. Main measures: Assessments included clinical examination and standardised instruments. Agitation was assessed with the Agitated Behaviour Scale, the course of recovery by the Rancho Los Amigo Scale and outcome by Glasgow Outcome Scale Extended. Results: Agitation were most common at 3 weeks post injury and 28% (n=68) of the patients showed at least one agitated behaviour requiring intervention from staff. Presence of significant agitation at 3 weeks after injury was not associated with poor outcome. At 3 months agitation was present in 11% (n=90) and apathy in 26 out of 81 assessed patients. At 3 months agitation and apathy were associated with poor outcome at one year. Conclusions: Most agitated behaviours in the early phase are transient and are not associated with poor outcome. Agitation and apathy are uncommon at three months but when present are associated with poor outcome at one year after injury. In the early phase after a severe traumatic brain injury agitated behaviour in need of interventions from staff occur in a substantial proportion of patients.

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“…These psychiatric symptoms may be divided into two categories: [6] cognitive and behavioral presentations.…”

Section: Introductionmentioning

confidence: 99%

About symptoms of patients with post traumatic brain injury psychiatric sequels

Mittler-Matica¹

2015

Romanian Neurosurgery

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Introduction: Because of high incidence, even if not permanently, some post traumatic brain injury (TBI) psychiatric sequels, are analysed. Material and methods: The paper refers to 1185 patients who were admitted to Section I Psychiatry, Neurology and Psychiatry Hospital, Oradea, during 2013 year. It was analysed the symptoms of those who suffered a TBI in the past; patients called: patients in the analysis group. The linear correlation coefficient was computed, in purpose to determine the relationship between duration relapses and number of symptoms. Results: It is observed a strong correlation between the years number of relapse (of post-TBI psychiatric disease) and the number of psychiatric symptoms associated. For 80% of psychiatric relapses after a TBI with loss of conscious (about patients in the analysis group), the TBI were suffered in infancy; such an incident in infancy may have severe influence on mental health. The psychiatric disease (for which they were admitted in hospital) worsened general health status at a percentage of 83.58% patients in the analysis group. The average by hospitalization days was 11.58; with approximation it was 12 days. Discussion: The most common symptoms of post-TBI psychiatric disease, which affects physical functionalities of patients in the analysis group, were: insomnia, fatigue, headache (64.66% have accused insomnia; 41.18% have accused weakness and / or fatigue; 33.34% have accused headache). Average by age of the patients in the analysis group with reduced instincts was 45.08 years. Women patients preserve better the instincts excepting defense instinct which diminishes more often compared to men patients in the analysis group.

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Neurobehavioral sequelae of traumatic brain injury

Cited by 106 publications

References 57 publications

Prospective study of myelin water fraction changes after mild traumatic brain injury in collegiate contact sports

Prospective study of myelin water fraction changes after mild traumatic brain injury in collegiate contact sports

Behavioural problems in the first year after Severe traumatic brain injury: a prospective multicentre study

About symptoms of patients with post traumatic brain injury psychiatric sequels

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