Neurobehavioral Syndromes in Cocaine-Exposed Newborn Infants

Lester, Barry M.; Corwin, Michael J.; Sepkoski, Carol; Seifer, Ronald; Peucker, Mark; McLaughlin, Sarah A.; Golub, Howard

doi:10.2307/1131171

Cited by 104 publications

(17 citation statements)

References 31 publications

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“…The results of this study should be viewed within the context of how the social environment contributes to the developmental course of the cocaine-exposed infant. Although work continues to show the adverse effects of cocaine exposure, polydrug exposure, or both on early neurobehavioral development (e.g., Coles et al, 1992;Lester et al, 1991;Phillips et al, 1996), the developmental course of the infant may continue to be adversely affected by a withdrawn caregiving environment. Experimental work long ago showed that infants with similar neurobehavioral characteristics, including higher pitched cries, may have mothers who increasingly withdraw over time and that this withdrawal has increasingly adverse effects on the infant's intellectual and social development through at least the first 3 years of life (Zeskind & Ramey, 1978, 1981.…”

Section: Discussionmentioning

confidence: 99%

“…Further, some studies suggest that cocaine-exposed neonates exhibit increased irritability and other neurobehavioral characteristics that may adversely impact mother-infant interactions (e.g., Mayes, Bornstein, Chawarski, & Haynes, 1996;Phillips, Sharma, Premachandra, Vaughn, & Reyes-Lee, 1996). The high-pitched cry sounds often characteristic of drug-exposed infants (Lester et al, 1991;Zeskind, Coles, Platzman, & Schuetze, 1996) may also disrupt optimal mother-infant interactions. Higher pitched cry sounds are associated with greater infant distress, such as increased hunger or pain (Wasz-Hockert, Lind, Vuorenkoski, Partanen, & Valanne, 1968), and perceptions that the cry is generally more distressing (Bisping, Steingrueber, Oltmann, & Wenk, 1990;Boukydis & Burgess, 1982;Gustafson & Green, 1989;Zeskind & Lester, 1978;Zeskind & Marshall, 1988).…”

mentioning

confidence: 99%

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The Perceptions of Infant Distress Signals Varying in Pitch by Cocaine‐Using Mothers

Schuetze¹,

Zeskind²,

Eiden³

2003

Infancy

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Perceptual responses to infant distress signals were studied in 16 cocaine‐using and 15 comparison mothers. All mothers rated tape recordings of 48 replications of a newborn infant's hunger cry digitally altered to increase in fundamental frequency in 100‐Hz increments. Cries were rated on 4 perceptual (arousing, aversive, urgent, and sick) and 6 caregiving rating scale items (clean, cuddle, feed, give pacifier, pick up, and wait and see) used in previous studies. Analyses of variance showed that, as cry pitch increased, cries were rated as more arousing, aversive, and urgent sounding. The highest pitched cries received the highest ratings for caregiving interventions. Main effects for cocaine use showed cocaine‐using mothers (a) rated cries as less arousing, aversive, urgent, and sick; (b) indicated they were less likely to pick up or feed the infant; and (c) indicated they more likely to give the crying infant a pacifier or just “wait and see.” A Group x Cry Pitch interaction effect showed that mothers in the cocaine group gave higher ratings to wait and see as the pitch of the cries increased, whereas mothers in the comparison group gave lower ratings to wait and see as the pitch of the cries increased. These ratings indicate that cocaine‐using mothers found cries to be less perceptually salient and less likely to elicit nurturant caregiving responses. These results suggest that maternal cocaine use is associated with altered perceptions of infant distress signals that may provide the basis for differential social responsivity in the caregiving context.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The Perceptions of Infant Distress Signals Varying in Pitch by Cocaine‐Using Mothers

Schuetze¹,

Zeskind²,

Eiden³

2003

Infancy

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“…Acoustic analysis procedures. The resulting corpus of cry episodes was subjected to acoustic analysis using a computer system that has been specifically designed and well validated to perform cry analyses in infants [Corwin et al, 1992[Corwin et al, , 1995Lester et al, 1991]. Cry signals were filtered above 5 kHz and digitized at 10 kHz.…”

Section: Identification and Coding Of Cry Episodesmentioning

confidence: 99%

Atypical Cry Acoustics in 6‐Month‐Old Infants at Risk for Autism Spectrum Disorder

Sheinkopf¹,

et al. 2012

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This study examined differences in acoustic characteristics of infant cries in a sample of babies at risk for autism and a low-risk comparison group. Cry samples derived from vocal recordings of 6-month-old infants at risk for autism spectrum disorder (ASD; n = 21) and low-risk infants (n = 18) were subjected to acoustic analyses using analysis software designed for this purpose. Cries were categorized as either pain-related or non-pain-related based on videotape coding. At-risk infants produced pain-related cries with higher and more variable fundamental frequency (F0) than low-risk infants. At-risk infants later classified with ASD at 36 months had among the highest F0 values for both types of cries and produced cries that were more poorly phonated than those of nonautistic infants, reflecting cries that were less likely to be produced in a voiced mode. These results provide preliminary evidence that disruptions in cry acoustics may be part of an atypical vocal signature of autism in early life.

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“…For example, in response to prenatal cocaine exposure, some newborn infants show increased hyperphonation, dysphonation, and cry duration (Lester et al, 2002), while others show less hyperphonation and fewer cry utterances or expirations (Corwin et al, 1992). These dual syndromes may be due, respectively, to the excitatory direct effects of prenatal cocaine on nervous system activity, as compared to a depressive pattern of behavior that results from the indirect effects of concurrent malnutrition (Lester et al, 1991). …”

Section: Neurobehavioral Assessmentmentioning

confidence: 99%

Development of Translational Methods in Spectral Analysis of Human Infant Crying and Rat Pup Ultrasonic Vocalizations for Early Neurobehavioral Assessment

Zeskind¹,

McMurray²,

Garber³

et al. 2011

Front. Psychiatry

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The purpose of this article is to describe the development of translational methods by which spectrum analysis of human infant crying and rat pup ultrasonic vocalizations (USVs) can be used to assess potentially adverse effects of various prenatal conditions on early neurobehavioral development. The study of human infant crying has resulted in a rich set of measures that has long been used to assess early neurobehavioral insult due to non-optimal prenatal environments, even among seemingly healthy newborn and young infants. In another domain of study, the analysis of rat put USVs has been conducted via paradigms that allow for better experimental control over correlated prenatal conditions that may confound findings and conclusions regarding the effects of specific prenatal experiences. The development of translational methods by which cry vocalizations of both species can be analyzed may provide the opportunity for findings from the two approaches of inquiry to inform one another through their respective strengths. To this end, we present an enhanced taxonomy of a novel set of common measures of cry vocalizations of both human infants and rat pups based on a conceptual framework that emphasizes infant crying as a graded and dynamic acoustic signal. This set includes latency to vocalization onset, duration and repetition rate of expiratory components, duration of inter-vocalization-intervals and spectral features of the sound, including the frequency and amplitude of the fundamental and dominant frequencies. We also present a new set of classifications of rat pup USV waveforms that include qualitative shifts in fundamental frequency, similar to the presence of qualitative shifts in fundamental frequency that have previously been related to insults to neurobehavioral integrity in human infants. Challenges to the development of translational analyses, including the use of different terminologies, methods of recording, and spectral analyses are discussed, as well as descriptions of automated processes, software solutions, and pitfalls.

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Neurobehavioral Syndromes in Cocaine-Exposed Newborn Infants

Cited by 104 publications

References 31 publications

The Perceptions of Infant Distress Signals Varying in Pitch by Cocaine‐Using Mothers

The Perceptions of Infant Distress Signals Varying in Pitch by Cocaine‐Using Mothers

Atypical Cry Acoustics in 6‐Month‐Old Infants at Risk for Autism Spectrum Disorder

Development of Translational Methods in Spectral Analysis of Human Infant Crying and Rat Pup Ultrasonic Vocalizations for Early Neurobehavioral Assessment

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