Neurobehavioural deficits after severe traumatic brain injury (TBI)

Lippert-Grüner, M.; Kuchta, Johannes; Hellmich, Martin; Klug, N.

doi:10.1080/02699050600664467

Cited by 60 publications

(41 citation statements)

References 11 publications

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“…Clinically, TBI to the frontal cortex has been associated with disruptions in motor function, problem solving, spontaneity, memory, judgment, impulse control, and social behavior (Levin et al, 1987). Although the underlying cellular and molecular pathophysiology is not fully understood, post-TBI behavioral deficits such as aggressive behavior, anxiety, and depression, as well as an increased risk for epilepsy may last for months to years (Fujii and Ahmed, 2002;Giza and Prins, 2006;Lippert-Gruner et al, 2006). Only a small number of experimental TBI studies have evaluated and shown extended behavioral deficits (Adelson et al, 2000;Huh and Raghupathi, 2007;Prins and Hovda, 1998).…”

Section: Introductionmentioning

confidence: 99%

Traumatic Brain Injury in Young Rats Leads to Progressive Behavioral Deficits Coincident with Altered Tissue Properties in Adulthood

Ajao

Pop

Adami

et al. 2012

Journal of Neurotrauma

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Traumatic brain injury (TBI) affects many infants and children, and results in enduring motor and cognitive impairments with accompanying changes in white matter tracts, yet few experimental studies in rodent juvenile models of TBI (jTBI) have examined the timeline and nature of these deficits, histologically and functionally. We used a single controlled cortical impact (CCI) injury to the parietal cortex of rats at post-natal day (P) 17 to evaluate behavioral alterations, injury volume, and morphological and molecular changes in gray and white matter, with accompanying measures of electrophysiological function. At 60 days post-injury (dpi), we found that jTBI animals displayed behavioral deficits in foot-fault and rotarod tests, along with a left turn bias throughout their early developmental stages and into adulthood. In addition, anxiety-like behaviors on the zero maze emerged in jTBI animals at 60 dpi. The final lesion constituted only *3% of brain volume, and morphological tissue changes were evaluated using MRI, as well as immunohistochemistry for neuronal nuclei (NeuN), myelin basic protein (MBP), neurofilament-200 (NF200), and oligodendrocytes (CNPase). White matter morphological changes were associated with a global increase in MBP immunostaining and reduced compound action potential amplitudes at 60 dpi. These results suggest that brain injury early in life can induce long-term white matter dysfunction, occurring in parallel with the delayed development and persistence of behavioral deficits, thus modeling clinical and longitudinal TBI observations.

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Section: Introductionmentioning

confidence: 99%

Traumatic Brain Injury in Young Rats Leads to Progressive Behavioral Deficits Coincident with Altered Tissue Properties in Adulthood

Ajao

Pop

Adami

et al. 2012

Journal of Neurotrauma

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“…[16][17][18] Study design has been described previously. 16,17 In brief, inclusion criteria were severe, non-penetrating, traumatic brain injury requiring neurointensive care, with acute Glasgow Coma Scale score of [3][4][5][6][7][8]19 in adult patients aged 18-65 years. Exclusion criteria were death or expected death within 3 weeks of injury.…”

Section: Methodsmentioning

confidence: 99%

“…A variety of terms have been used to describe these behavioural changes. [5][6][7][8][9] Descriptions in the literature pertaining to TBI include variations of "neurobehavioral symptoms", 5 "neuropsychatric consequences" 6 as well as standard definitions of psychiatric disorders (e.g. according to Diagnostic System Manual DSM 10 or International Classification of Disease ICD criteria), 11 applied to patients after traumatic brain injury.…”

Section: Introductionmentioning

confidence: 99%

Behavioural problems in the first year after Severe traumatic brain injury: a prospective multicentre study

et al. 2016

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Objective: To investigate the occurrence of behavioural problems in patients with severe traumatic brain injury during the first year after injury and potential associations with outcome. An additional post hoc objective was to analyse the frequency of behaviours with need for intervention from staff. Design and setting: In a prospective population based cohort study 114 patients with severe traumatic brain injury were assessed at three weeks, three months and one year after injury. Main measures: Assessments included clinical examination and standardised instruments. Agitation was assessed with the Agitated Behaviour Scale, the course of recovery by the Rancho Los Amigo Scale and outcome by Glasgow Outcome Scale Extended. Results: Agitation were most common at 3 weeks post injury and 28% (n=68) of the patients showed at least one agitated behaviour requiring intervention from staff. Presence of significant agitation at 3 weeks after injury was not associated with poor outcome. At 3 months agitation was present in 11% (n=90) and apathy in 26 out of 81 assessed patients. At 3 months agitation and apathy were associated with poor outcome at one year. Conclusions: Most agitated behaviours in the early phase are transient and are not associated with poor outcome. Agitation and apathy are uncommon at three months but when present are associated with poor outcome at one year after injury. In the early phase after a severe traumatic brain injury agitated behaviour in need of interventions from staff occur in a substantial proportion of patients.

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“…However, an evaluation of the difficulty in providing care for survivors with TBI during the immediate rehabilitation phase after discharge from hospital has been recommended (1,3). Not many studies have been done to describe conditions related to the disability of survivors during the early rehabilitation phase (3), especially at one month after survivors are discharged from hospital and during continued home-based care.…”

Section: Introductionmentioning

confidence: 99%

“…Survivors with traumatic brain injury are dependent on caregivers in the early stage following discharge from hospital, because neurobehavioral and/or physical deficits remain present even at 6-12 months post-injury (3,4). The caregivers of these survivors play a major role in fulfilling the demanding mission of facilitating recovery and rehabilitation (1,5).If the caregivers are unable to deal with this difficult situation, feelings of heavy burden, stress, anxiety and depression can occur, thereby leading to a decline in the status of their health (6,7).The aforementioned conditions affect functioning and caregiving ability (8).In turn, ineffective caregiving or inability to accomplish caregiving tasks can impact the patient´s health status and disability rehabilitation (9).…”

Section: Introductionmentioning

confidence: 99%

Coping and Health Problems of Caregivers of Survivors with Traumatic Brain Injury

Chayaput¹,

Utriyaprasit²,

Bootcheewan³

et al. 2014

Aquichan

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Objetivos: Evaluar el afrontamiento y los problemas de salud de los cuidadores en el momento en que el sobreviviente fue dado de alta y un mes después de que el sobreviviente fue dado de alta y determinar las correlaciones entre los datos de carácter personal, afrontamiento y los problemas de salud de los cuidadores y la incapacidad de los sobrevivientes. Método: Ochenta y cinco díadas de supervivientes con lesiones cerebrales traumáticas y sus cuidadores fueron incluidos en la investigación. Los instrumentos utilizados para la recolección de datos fueron la versión tailandesa de la Escala de Medición del Proceso de Afrontamiento y Adaptación – Formato Corto, con 27 ítems, el Cuestionario de Problemas de Salud para los cuidadores y la Clasificación de Escala de Discapacidad para los sobrevivientes. El Modelo de Adaptación de Roy se utilizó como marco conceptual para este estudio. La correlación producto-momento de Pearson se utilizó para el análisis. Resultados: No se encontraron diferencias estadísticas entre los problemas de afrontamiento y de salud en los cuidadores. Los problemas de salud reportados más frecuentemente por los cuidadores fueron dolor de cabeza en el día de alta y ningún problema de salud después de un mes de participación en el cuidado del sobreviviente. El nivel de la discapacidad de los sobrevivientes y el estado civil de los cuidadores se correlacionaron negativamente con el afrontamiento (r = - 0,245 , p = 0,024 , r = - 0,220 , p = 0,043 , respectivamente). Conclusiones: Los resultados demuestran que los cuidadores permanecieron capaces de manejar las dificultades que implica el cuidado de los sobrevivientes en casa con menos problemas de salud. Los cuidadores casados eran propensos a manejar esta carga mejor que otros cuidadores.

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Neurobehavioural deficits after severe traumatic brain injury (TBI)

Cited by 60 publications

References 11 publications

Traumatic Brain Injury in Young Rats Leads to Progressive Behavioral Deficits Coincident with Altered Tissue Properties in Adulthood

Traumatic Brain Injury in Young Rats Leads to Progressive Behavioral Deficits Coincident with Altered Tissue Properties in Adulthood

Behavioural problems in the first year after Severe traumatic brain injury: a prospective multicentre study

Coping and Health Problems of Caregivers of Survivors with Traumatic Brain Injury

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