Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior

Maestripieri, Dario; Lindell, Stephen G.; Ayala, Alejandro; Gold, Philip W.; Higley, J. Dee

doi:10.1016/j.neubiorev.2004.05.004

Cited by 74 publications

(51 citation statements)

References 35 publications

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“…This pattern of hyperresponsiveness has also been reported in several nonhuman primate models of early adversity (Coplan et al, 1996;Smith et al, 2002) and in adult women with a history of prepubertal abuse (Heim et al, 2000(Heim et al, , 2002Heim and Nemeroff, 2001). Changes in nervous system CRF tone appear to be associated with these changes in HPA responsiveness, as illustrated by elevations in CSF CRFir in the adult HMS180 rats (Figure 2), in several primate models of early adversity (Coplan et al, 1996;Maestripieri et al, 2005), primates with fearful temperaments (Kalin et al, 2000), and in abused children as well as in adult women with a history of abuse (Heim and Nemeroff, 2001;Newport et al, 2003;Carpenter et al, 2004). Alternatively, we recently reported blunting of the diurnal cortisol rhythm in rhesus monkeys exposed to early adversity without accompanying changes in CSF CRFir (Sanchez et al, 2005).…”

Section: Discussionsupporting

confidence: 67%

Long-Term Consequences of Neonatal Rearing on Central Corticotropin-Releasing Factor Systems in Adult Male Rat Offspring

Plotsky

Thrivikraman

Nemeroff

et al. 2005

Neuropsychopharmacol

451

321

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In a series of studies on the long-term consequences of neonatal rearing, we compared hypothalamic and extrahypothalamic central corticotropin-releasing factor (CRF) systems in male rats reared under conditions of animal facility rearing, nonhandling (HMS0), handling with brief maternal separation for 15 min (HMS15), or handling with moderate maternal separation for 180 min (HMS180) daily from postnatal days 2-14. CRF-like immunoreactivity (CRFir) was elevated in lumbar cerebrospinal fluid of adult HMS180 and HMS0 rats relative to the other groups. In the paraventricular nucleus, central nucleus of the amygdala, bed nucleus of the stria terminalis, and locus coeruleus, CRFir and CRF mRNA levels were significantly elevated in HMS0 and HMS180 rats. Neonatal maternal separation was associated with regionally specific alterations in CRF receptor type 1 (CRF1) mRNA density in HMS180 rats. No rearing-associated differences in CRF2a binding were apparent in either the lateral septum or the ventromedial hypothalamus. These findings indicate that early rearing conditions can permanently alter the developmental set-point of central CRF systems, and potentially influence the expression of behavioral and endocrine responses to stress throughout life, thereby providing a possible neurobiological substrate for the relationship between early life events and increased vulnerability for hypothalamic-pituitary-adrenal axis and coping skill alterations and the frequency of mood disorders in patients with a history of such experiences.

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Section: Discussionsupporting

confidence: 67%

Long-Term Consequences of Neonatal Rearing on Central Corticotropin-Releasing Factor Systems in Adult Male Rat Offspring

Plotsky

Thrivikraman

Nemeroff

et al. 2005

Neuropsychopharmacol

451

321

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“…Abused females also may learn patterns of abusive behavior through observation of their mothers with their younger siblings. Another possibility is that early infant abuse results in long-term alterations of neural circuits or neuroendocrine processes that directly or indirectly affect the expression of maternal behavior (23).…”

Section: Discussionmentioning

confidence: 99%

Early experience affects the intergenerational transmission of infant abuse in rhesus monkeys

Maestripieri

2005

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

167

141

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Maternal abuse of offspring in macaque monkeys shares some similarities with child maltreatment in humans, including its transmission across generations. This study used a longitudinal design and a cross-fostering experiment to investigate whether abusive parenting in rhesus macaques is transmitted from mothers to daughters and whether transmission occurs through genetic or experiential factors. Nine of 16 females who were abused by their mothers in their first month of life, regardless of whether they were reared by their biological mothers or by foster mothers, exhibited abusive parenting with their firstborn offspring, whereas none of the females reared by nonabusive mothers did. These results suggest that the intergenerational transmission of infant abuse in rhesus monkeys is the result of early experience and not genetic inheritance. The extent to which the effects of early experience on the intergenerational transmission of abusive parenting are mediated by social learning or experience-induced physiological alterations remains to be established.child maltreatment ͉ animal models ͉ cross-fostering ͉ development ͉ primates

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“…They occur, for example, in patients with stress-related psychiatric disorders in which social behaviors are commonly compromised, such as anxiety and depression 142 . Abusive rhesus macaque mothers (who were abused themselves as infants) show higher CSF concentrations of CRH than controls and these are associated with antisocial behavior patterns 143 . The differences in the CRH system could be due to the early trauma or to genetic factors and findings in rats exposed to peripubertal stress indicate that early stress is a critical trigger.…”

Section: Extrahypothalamic Corticotropin Releasing Hormone (Crh)mentioning

confidence: 99%

Stress and the social brain: behavioural effects and neurobiological mechanisms

2015

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Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior

Cited by 74 publications

References 35 publications

Long-Term Consequences of Neonatal Rearing on Central Corticotropin-Releasing Factor Systems in Adult Male Rat Offspring

Long-Term Consequences of Neonatal Rearing on Central Corticotropin-Releasing Factor Systems in Adult Male Rat Offspring

Early experience affects the intergenerational transmission of infant abuse in rhesus monkeys

Stress and the social brain: behavioural effects and neurobiological mechanisms

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