Neurobiological disease etiology and inheritance: an epigenetic perspective

Saab, Bechara J.; Mansuy, Isabelle M

doi:10.1242/jeb.089995

Cited by 18 publications

(14 citation statements)

References 102 publications

(92 reference statements)

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“…It is important too that studies in the natural environment complement those in the laboratory, and that experiments take account of the relevance of particular stressors, and levels of exposure, to the species under study. Inter-generational effects, and the routes whereby these might be generated [see Saab and Mansuy in this issue (Saab and Mansuy, 2014)] are of great interest; here again, careful experimental design that separates direct and indirect environmental and genetic effects is extremely important. This is not a simple task, as when an organism is exposed to stress during embryonic development, its own germ line, and thereby its offspring, could be directly affected.…”

Section: Reviewmentioning

confidence: 99%

Organismal stress, telomeres and life histories

Monaghan

2014

Journal of Experimental Biology

201

203

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Most organisms, including ourselves, are exposed to environmental stressors at various points during life, and responses to such stressors have been optimised by evolution to give the best fitness outcomes. It is expected that environmental change will substantially increase long-term stress exposure in many animal groups in the coming decades. A major challenge for biologists is to understand and predict how this will influence individuals, populations and ecosystems, and over what time scale such effects will occur. This requires a multi-disciplinary approach, combining studies of mechanisms with studies of fitness consequences for individuals and their descendants. In this review, I discuss the positive and negative fitness consequences of responses to stressful environments, particularly during early life, and with an emphasis on studies in birds. As many of the mechanisms underlying stress responses are highly conserved across the vertebrate groups, the findings from these studies have general applicability when interpreted in a life history context. One important route that has recently been identified whereby chronic stress exposure can affect health and longevity over long time frames is via effects on telomere dynamics. Much of this work has so far been done on humans, and is correlational in nature, but studies on other taxa, and experimental work, are increasing. I summarise the relevant aspects of vertebrate telomere biology and critically appraise our current knowledge with a view to pointing out important future research directions for our understanding of how stress exposure influences life histories.

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Section: Reviewmentioning

confidence: 99%

Organismal stress, telomeres and life histories

Monaghan

2014

Journal of Experimental Biology

201

203

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“…Additionally, ELS has also been shown to modulate the promoter methylation status of several genes investigated in the germline of males (Franklin et al, 2010). )For a review of the current literature and further discussion of this area please see: Bohacek et al, 2013; Ho & Burggren, 2010; Kovalchuk, 2012; Saab & Mansuy, 2014). …”

Section: Transgenerational Epigeneticsmentioning

confidence: 99%

Early-life stress interactions with the epigenome

Lewis

2014

Behavioural Pharmacology

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Throughout the 20th century a body of literature concerning the long lasting effects of early environment was produced. Adverse experiences in early life, or early life stress (ELS), is associated with a higher risk for developing various psychiatric illnesses. The mechanisms driving the complex interplay between ELS and adult phenotype has baffled many investigators for decades. Over the last decade, the new field of neuroepigenetics has emerged as one possible mechanism by which ELS can have far reaching effects on adult phenotype, behavior, and risk for psychiatric illness. Here we review two commonly investigated epigenetic mechanisms, histone modifications and DNA methylation, and the emerging field of neuroepigenetics as they relate to ELS. We discuss the current animal literature demonstrating ELS induced epigenetic modulation of gene expression that results in altered adult phenotypes. We also briefly discuss other areas in which neuroepigenetics has emerged as a potential mechanism underlying environmental and genetic interactions.

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“…Environmental factors such as stress, diet and toxins have been shown to influence transgenerational inheritance relevant to neurobiological disease, including depression, anxiety, addiction, and ASD (Roth et al, 2009; Vassoler and Sadri-Vakili, 2013; Saab and Mansuy, 2014). Fewer studies have investigated the transgenerational effects of enriching environments on behavior.…”

mentioning

confidence: 99%

Transgenerational effects of environmental enrichment on repetitive motor behavior development

Bechard

Lewis

2016

Behavioural Brain Research

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The favorable consequences of environmental enrichment (EE) on brain and behavior development are well documented. Much less is known, however, about transgenerational benefits of EE on non-enriched offspring. We explored whether transgenerational effects of EE might extend to the development of repetitive motor behaviors in deer mice. Repetitive motor behaviors are invariant patterns of movement that, across species, can be reduced by EE. We found that EE not only attenuated the development of repetitive behavior in dams, but also in their non-enriched offspring. Moreover, maternal behavior did not seem to mediate the transgenerational effect we found, although repetitive behavior was affected by reproductive experience. These data support a beneficial transgenerational effect of EE on repetitive behavior development and suggest a novel benefit of reproductive experience.

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Neurobiological disease etiology and inheritance: an epigenetic perspective

Cited by 18 publications

References 102 publications

Organismal stress, telomeres and life histories

Organismal stress, telomeres and life histories

Early-life stress interactions with the epigenome

Transgenerational effects of environmental enrichment on repetitive motor behavior development

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