Neurobiological effects of gallic acid: current perspectives

Bhuia, Md. Shimul; Rahaman, Md. Mizanur; Islam, Tawhida; Bappi, Mehedi Hasan; Sikder, Md Iqbal; Hossain, Kazi Nadim; Akter, Fatama; Prottay, Abdullah Al Shamsh; Rokonuzzman, Md.; Gürer, Eda Sönmez; Călina, Daniela; Islam, Muhammad Torequl; Sharifi‐Rad, Javad

doi:10.1186/s13020-023-00735-7

Cited by 63 publications

(25 citation statements)

References 176 publications

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“…Inflammation plays a key role in the host's defense against pathogens, but it is also essential for the repair of tissues, regeneration, and reconstruction, and subtle forms of inflammation are indispensable for the maintenance of tissue homeostasis. [91,92] Studies have shown that both chronic and acute inflammatory processes strongly influence cancer development. Advances in inflammation research have uncovered a link between inflammatory processes and neoplastic transformation, tumor development, and the progression of metastases and recurrences.…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches

Bhuia,

Chowdhury,

Sonia

et al. 2023

Chemistry & Biodiversity

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With the increasing prevalence of cancer and the toxic side effects of synthetic drugs, natural products are being developed as promising therapeutic approaches. Gracillin is a naturally occurring triterpenoid steroidal saponin with several therapeutic activities. It is obtained as a major compound from different Dioscorea species. This review was designated to summarize the research progress on the anti‐cancer activities of gracillin focusing on the underlying cellular and molecular mechanisms, as well as its pharmacokinetic features. The data were collected (up to date as of May 1, 2023) from various reliable and authentic literatures comprising PubMed, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar. The findings demonstrated that gracillin displays promising anticancer effects through various molecular mechanisms, including anti‐inflammatory effects, apoptotic cell death, induction of oxidative stress, cytotoxicity, induction of genotoxicity, cell cycle arrest, anti‐proliferative effect, autophagy, inhibition of glycolysis, and blocking of cancer cell migration. Additionally, this review highlighted the pharmacokinetic features of gracillin, indicating its lower oral bioavailability. As a conclusion, it can be proposed that gracillin could serve as a hopeful chemotherapeutic agent. However, further extensive clinical research is recommended to establish its safety, efficacy, and therapeutic potential in cancer treatment.

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Section: Anti-inflammatory Effectmentioning

confidence: 99%

Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches

Bhuia,

Chowdhury,

Sonia

et al. 2023

Chemistry & Biodiversity

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“…This results in chemical chain reactions (called oxidation reactions) that can have beneficial or harmful consequences (Calina et al, 2020;Mititelu et al, 2020;Islam et al, 2021;Amin et al, 2022). Due to their chelating ability and antioxidant activity many compounds can act as regulators of heme iron excess, avoiding oxygen-initiated free radical formation and, ultimately, preventing damaging Fenton reactions (Nussbaum et al, 2017;Buga et al, 2019;Calina et al, 2020;Bhuia et al, 2023). Furthermore, inositol hexaphosphate (IP6) also proved to be effective in reducing the occurrence of metal-catalyzed protein glycation, such as advanced glycation end products (AGEs), which may trigger diabetes-related diseases (López-Moreno et al, 2022).…”

Section: Phytate As Antioxidantmentioning

confidence: 99%

Phytates as a natural source for health promotion: A critical evaluation of clinical trials

et al. 2023

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Phytates are a type of organophosphorus compound produced in terrestrial ecosystems by plants. In plant feeds, phytic acid and its salt form, phytate, account for 60%–80% of total phosphorus. Because phytate is a polyanionic molecule, it can chelate positively charged cations such as calcium, iron, and zinc. Due to its prevalence in vegetal tissues and the fact that people consume plants, phytate was first considered a potential health benefit. This updated review aims to summarize the current data on the results of clinical trials of phytates on human health, highlighting both beneficial and undesirable effects. To obtain these updated data, published papers in electronic databases such as PubMed/MedLine, TRIP database, Wiley, Google Scholar, Baidu, and Scopus were searched. Study results have shown that phytate can have beneficial health effects such as antioxidant, anticancer potential and reduction of pathological calcifications in blood vessels and organs; but also, negative effects by reducing the absorption of minerals important for maintaining the homeostasis of the human body. According to these recent results derived from recent clinical studies, phytates may be a potential natural source for health benefits. To improve clinical efficacy and human health benefits, further dose-response studies are needed to determine effective therapeutic doses and potential interactions with conventional drugs.

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“…By reacting with almost all of the molecules present in living cells, including DNA, these reactive species cause oxidative damage [52,53] . Elevated levels of intrinsic or extrinsic free radicals and high levels of lipid peroxides, which are the etiology of several degenerative conditions including atherosclerosis, cancer, diabetes, Alzheimer's disease, cataracts, aging, and so on, are produced by excess ROS if the antioxidant system is not able to remove them [50,54] . Consequently, to maintain the antioxidant system, different synthetic antioxidants including butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), and propyl gallate (PG) have been used, but these are not safe, accessible, and affordable [55] .…”

Section: Traditional Usesmentioning

confidence: 99%

“…[52,53] Elevated levels of intrinsic or extrinsic free radicals and high levels of lipid peroxides, which are the etiology of several degenerative conditions including atherosclerosis, cancer, diabetes, Alzheimer's disease, cataracts, aging, and so on, are produced by excess ROS if the antioxidant system is not able to remove them. [50,54] Consequently, to maintain the antioxidant system, different synthetic antioxidants including butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), and propyl gallate (PG) have been used, but these are not safe, accessible, and affordable. [55] As a result of the serious effects of OS and the limitations of synthetic antioxidants, there is a demand for replacement antioxidants compounds that are safer, and easily accessible, as well as potent.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Mikania micranthaKunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential

Ali Khan,

El‐Kersh,

Islam

et al. 2023

Chemistry & Biodiversity

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Mikania micrantha is utilized as a therapeutic for the treatment of various human ailments including insect bites, rashes and itches of skin, chicken pox, healing of sores and wounds, colds and fever, nausea, jaundice, rheumatism, and respiratory ailments. This study aimed at summarizing the traditional uses, phytochemical profile, and biological activities of M. micrantha based on obtainable information screened from different databases. The results suggest that fresh leaves and whole plant are frequently used in folk medicine. The plant contains more than 150 different phytochemicals under the following groups: essential oils, phenolics and flavonoids, terpenes, terpene lactones, glycosides, and sulfated flavonoids. It contains carbohydrates and micronutrients including vitamins and major and trace minerals. M. micrantha possesses antioxidant, anti‐inflammatory, anti‐microbial, anti‐dermatophytic, anti‐protozoal, anthelmintic, cytotoxic, anxiolytic, anti‐diabetic, lipid‐lowering and antidiabetic, spasmolytic, memory‐enhancing, wound‐healing, anti‐aging, and thrombolytic activities. No clinical studies have been reported to date. M. micrantha might be one of the potential sources of phytotherapeutic compounds against diverse ailments in humans. Studies are required to confirm its safety profile in experimental animals prior to initiating clinical trials. Moreover, adequate investigation is also crucial to clarify exact mechanism of action for each biological effect.

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Neurobiological effects of gallic acid: current perspectives

Cited by 63 publications

References 176 publications

Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches

Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches

Phytates as a natural source for health promotion: A critical evaluation of clinical trials

Mikania micranthaKunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential

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