Neurobiological mechanisms of the rewars and punishment systems in the brain afteractivation of nucleus accumbens

Feeding behavior includes both the satisfaction of metabolic nutrient requirements and the hedonic aspects of pleasure. The orexigenic hormone ghrelin increases motivation to food intake. In addition, by modulating the reward system, ghrelin enhances the rewarding properties of non-food stimuli. The dopaminergic mesolimbic system plays a key role in the mechanisms of reward. Ghrelin regulates the activity of this system by acting on several levels of brain organization. The hierarchy of ghrelin-sensitive neural networks, as well as afferent connections and reciprocal interactions between its components, mediating the effect of ghrelin on the process of motivation in metabolic and hedonic type of feeding are considered.

show abstract

Ghrelin mechanisms of food reward. Part 2. Interaction of ghrelin with hormones, neuropeptides and other endogenous ligands

Рейхардт

Shabanov²

2022

Rev Clin Pharm Drug Ther

View full text Add to dashboard Cite

The hunger hormone, ghrelin, is produced not only in response to food deprivation, but is also released during various types of stress. In recent years, the rise in ghrelin levels has come to be seen as an essential component of the stress response. The review is devoted to ghrelin-dependent mechanisms providing reciprocal interaction between the hypothalamuspituitaryadrenal cortex axis and the dopaminergic reward system. Direct and feedback links between the stress-realizing system of the paraventricular nucleus, the neural networks of the lateral hypothalamus and the arcuate nucleus (which form the centers of hunger/satiation), and the mesolimbic reward system are considered. The role of peripheral satiety hormones and glucocorticoids in the regulation of motivation and reinforcement is discussed, as well as the involvement of endogenous opioid and endocannabinoid receptors in the learning of dopaminergic neurons in the ventral tegmental area and the hippocampus.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Neurobiological mechanisms of the rewars and punishment systems in the brain afteractivation of nucleus accumbens

Cited by 5 publications

References 37 publications

Registration of Changes in the Level of Extracellular Dopamine in the Nucleus Accumbens by Fast-Scan Cyclic Voltammetry during Stimulation of the Zone of the Ventral Tegmentаl Area, Which Also Caused a Self-Stimulation

Registration of Changes in the Level of Extracellular Dopamine in the Nucleus Accumbens by Fast-Scan Cyclic Voltammetry during Stimulation of the Zone of the Ventral Tegmentаl Area, Which Also Caused a Self-Stimulation

Ghrelin-dependent mechanisms of food reward. Part 1. Ghrelin and dopamine

Ghrelin mechanisms of food reward. Part 2. Interaction of ghrelin with hormones, neuropeptides and other endogenous ligands

Contact Info

Product

Resources

About