Neurobiological Models of the Central Complex and the Mushroom Bodies

Strauß, Roland

doi:10.1007/978-3-319-02362-5_1

Cited by 3 publications

(8 citation statements)

References 68 publications

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“…[71][72][73] The CC is thus considered to be a center for "decision-making" in the fly. [71][72][73] The CC is thus considered to be a center for "decision-making" in the fly.…”

Section: Neural Agingmentioning

confidence: 99%

“…Another structure in the fly brain, the central complex (CC), integrates various inputs into a coherent behavioral output, not only for locomotion but also sleep, arousal, and learning. [71][72][73] The CC is thus considered to be a center for "decision-making" in the fly. The behaviors of CC mutants mimic some of the deficits that are observed in aging flies, 74 displaying an altered locomotion.…”

Section: Neural Agingmentioning

confidence: 99%

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Social behavior and aging: A fly model

Brenman-Suttner

Yost

Frame

et al. 2019

Genes Brain and Behavior

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The field of behavioral genetics has recently begun to explore the effect of age on social behaviors. Such studies are particularly important, as certain neuropsychiatric disorders with abnormal social interactions, like autism and schizophrenia, have been linked to older parents. Appropriate social interaction can also have a positive impact on longevity, and is associated with successful aging in humans. Currently, there are few genetic models for understanding the effect of aging on social behavior and its potential transgenerational inheritance. The fly is emerging as a powerful model for identifying the basic molecular mechanisms underlying neurological and neuropsychiatric disorders. In this review, we discuss these recent advancements, with a focus on how studies in Drosophila melanogaster have provided insight into the effect of aging on aspects of social behavior, including across generations.

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“…[71][72][73] The CC is thus considered to be a center for "decision-making" in the fly. [71][72][73] The CC is thus considered to be a center for "decision-making" in the fly.…”

Section: Neural Agingmentioning

confidence: 99%

Section: Neural Agingmentioning

confidence: 99%

Social behavior and aging: A fly model

Brenman-Suttner

Yost

Frame

et al. 2019

Genes Brain and Behavior

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“…Most of these modules—referred to as local processing units (LPUs) are characterized by unique populations of local neurons; some—called hubs—do not contain any local neurons (Chiang et al, 2011 ). The central complex (CX) comprises between 2,000 and 5,000 neurons (Strauss, 2014 ) organized in four neuropils: the protocerebral bridge (PB), fan-shaped body (FB), ellipsoid body (EB), and noduli (NO) (Figure 1 ). Local neurons have been identified in PB and FB, but not in EB or NO (Chiang et al, 2011 ; Wolff et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

“…EB appears to be involved in visual place learning (Ofstad et al, 2011 ; Dewar et al, 2015 ), short-term orientation memory (Neuser et al, 2008 ; Seelig and Jayaraman, 2013 ; Wystrach et al, 2014 ), angular path integration (Seelig and Jayaraman, 2015 ), and left-right bargaining (Strauss, 2014 );…”

Section: Introductionmentioning

confidence: 99%

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Generating Executable Models of the Drosophila Central Complex

Givon

Lazar

Yeh

2017

Front. Behav. Neurosci.

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The central complex (CX) is a set of neuropils in the center of the fly brain that have been implicated as playing an important role in vision-mediated behavior and integration of spatial information with locomotor control. In contrast to currently available data regarding the neural circuitry of neuropils in the fly's vision and olfactory systems, comparable data for the CX neuropils is relatively incomplete; many categories of neurons remain only partly characterized, and the synaptic connectivity between CX neurons has yet to be fully determined. Successful modeling of the information processing functions of the CX neuropils therefore requires a means of easily constructing and testing a range of hypotheses regarding both the high-level structure of their neural circuitry and the properties of their constituent neurons and synapses. To this end, we have created a web application that enables simultaneous graphical querying and construction of executable models of the CX neural circuitry based upon currently available information regarding the geometry and polarity of the arborizations of identified local and projection neurons in the CX. The application's novel functionality is made possible by the Fruit Fly Brain Observatory, a platform for collaborative study and development of fruit fly brain models.

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Generating an Executable Model of the Drosophila Central Complex

Givon

Lazar

2016

Preprint

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The central complex (CX) is a set of neuropils in the center of the fly brain that have been implicated as playing an important role in vision-mediated behavior and integration of spatial information for locomotor control. In contrast to currently available data regarding the neural circuitry of neuropils in the fly's vision and olfactory systems, comparable data for the CX neuropils is relatively incomplete; many categories of neurons remain only partly characterized, and the synaptic connectivity between CX neurons has yet to be experimentally determined. Successful modeling of the information processing functions of the CX neuropils therefore requires a means of easily constructing and testing a range of hypotheses regarding both the high-level structure of their neural circuitry and the properties of their constituent neurons and synapses. This document demonstrates how NeuroArch and Neurokernel may be used to algorithmically construct and evaluate executable neural circuit models of the CX neuropils and their interconnects based upon currently available information regarding the geometry and polarity of the arborizations of identified local and projection neurons in the CX.

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Neurobiological Models of the Central Complex and the Mushroom Bodies

Cited by 3 publications

References 68 publications

Social behavior and aging: A fly model

Social behavior and aging: A fly model

Generating Executable Models of the Drosophila Central Complex

Generating an Executable Model of the Drosophila Central Complex

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