Neurobiology of aversive states

Umberg, Erin N.; Pothos, Emmanuel N.

doi:10.1016/j.physbeh.2011.04.045

Cited by 17 publications

(14 citation statements)

References 182 publications

(167 reference statements)

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“…Opioid Dependence . Morphine dependence and withdrawal have been associated with alterations in cholinergic signaling pathways [ 89 – 91 ]. Our data demonstrate that chronic mecamylamine does not alter withdrawal syndrome in adult rats chronically treated with morphine.…”

Section: Discussionmentioning

confidence: 99%

Endogenous Cholinergic Neurotransmission Contributes to Behavioral Sensitization to Morphine

et al. 2015

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Neuroplasticity in the mesolimbic dopaminergic system is critical for behavioral adaptations associated with opioid reward and addiction. These processes may be influenced by cholinergic transmission arising from the laterodorsal tegmental nucleus (LDTg), a main source of acetylcholine to mesolimbic dopaminergic neurons. To examine this possibility we asked if chronic systemic morphine administration affects expression of genes in ventral and ventrolateral periaqueductal gray at the level of the LDTg using rtPCR. Specifically, we examined gene expression changes in the area of interest using Neurotransmitters and Receptors PCR array between chronic morphine and saline control groups. Analysis suggested that chronic morphine administration led to changes in expression of genes associated, in part, with cholinergic neurotransmission. Furthermore, using a quantitative immunofluorescent technique, we found that chronic morphine treatment produced a significant increase in immunolabeling of the cholinergic marker (vesicular acetylcholine transporter) in neurons of the LDTg. Finally, systemic administration of the nonselective and noncompetitive neuronal nicotinic antagonist mecamylamine (0.5 or 2 mg/kg) dose-dependently blocked the expression, and to a lesser extent the development, of locomotor sensitization. The same treatment had no effect on acute morphine antinociception, antinociceptive tolerance or dependence to chronic morphine. Taken together, the results suggest that endogenous nicotinic cholinergic neurotransmission selectively contributes to behavioral sensitization to morphine and this process may, in part, involve cholinergic neurons within the LDTg.

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Section: Discussionmentioning

confidence: 99%

Endogenous Cholinergic Neurotransmission Contributes to Behavioral Sensitization to Morphine

et al. 2015

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“…This brain region is activated in the presence of highly salient rewarding and aversive stimuli ( Di Chiara et al, 1999 ;Ito et al, 2000 ; Brought to you by | New York University Bobst Library Technical Services Authenticated Download Date | 5/27/15 9:33 PM Robinson and Berridge, 2000 ;Kelley and Berridge, 2002 ;Carelli, 2004 ;Carlezon and Thomas, 2009 ;Umberg and Pothos, 2011 ) and is involved in the regulation of both approach and avoidance behaviors ( Ikemoto and Panksepp, 1999 ). For example, both aversive and rewarding stimuli increase extracellular levels of dopamine in this region ( Kalivas and Duffy, 1995 ;Ikemoto, 2007 ;BrombergMartin et al, 2010 ), which suggests the general involvement of robust motivation in both positively and negatively valenced circumstances ( Schultz, 2006 ;Berridge, 2007 ;Di Chiara and Bassareo, 2007 ;Becker, 2009 ;Tsai et al, 2009 ;Koob and Volkow, 2010 ;Willuhn et al, 2010 ;Alcaro and Panksepp, 2011 ;Hull, 2011 ;Volkow et al, 2012 ).…”

Section: Aversive Motivation and The Regulation Of Selective Aggressionmentioning

confidence: 99%

“…Interestingly, CRF mRNA is upregulated in males that have remained in contact with their partner as well as in those that have been separated from their mating partner, which suggests that pair bonding may induce alterations in neural circuitry important for stress that specifically sensitize pair-bonded animals to separation distress ( Bosch et al, 2009 ). Thus, although acute activation of this system may serve a very important evolutionary purpose (i.e., motivating partner-seeking behavior), chronic activation may lead to dysregulation of systems mediating stress, and alterations in these aversive signaling systems may contribute to the development of mood disorders ( Umberg and Pothos, 2011 ).…”

Section: The Evolution Of Negative Affect To Reduce Partner Separationmentioning

confidence: 99%

Aversive motivation and the maintenance of monogamous pair bonding

Resendez

Aragona²

2013

Reviews in the Neurosciences

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Social bonds are important for human health and well-being, and a crucial component of these bonds is the ability to maintain a bond once it has been formed. Importantly, although bond maintenance is required for social attachments, very little is known about the neural mechanisms that mediate this behavior. Recently, laboratory studies utilizing the socially monogamous prairie vole (an excellent animal model for the neurobiology of selective social attachment), have allowed the neural correlates of selective social attachment to begin to unfold. These studies have identified that the activation of both motivational and hedonic processing systems, which mediate other natural rewards, is also important for mediating social behaviors that are characteristic of an established pair bond. These social behaviors include appetitive and positive social interactions with a potential mating partner in sexually naïve prairie voles, the avoidance of novel conspecifics (and sometimes aggressive rejection) that characterizes the established pair bond and, finally, an aversion towards partner separation. The following review will discuss how a balance between opposing endogenous opioid systems - positive (mu-opiod receptors) and aversive (kappa-opioid receptors) - provide essential hedonic signaling that guides socially motivated behaviors.

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“…Interestingly, a stronger hedonic response to palatable food has recently been implicated as a factor for weight gain (e.g., Salbe et al, 2004). Since reward and aversion might be mediated by overlapping neural systems and constitute an affective continuum (Umberg & Pothos, 2011), it is possible that liking of sweetness and disliking of bitterness express the same psychobiological trait in the risk for weight gain and overeating. Confirmation of this possibility might have considerable implications for nutritional, health and weight status.…”

Section: Discussionmentioning

confidence: 99%

Facial affective reactions to bitter-tasting foods and body mass index in adults

Garcia‐Burgos

Zamora

2013

Appetite

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Differences in food consumption among body-weight statuses (e.g., higher fruit intake linked with lower body mass index (BMI) and energy-dense products with higher BMI) has raised the question of why people who are overweight or are at risk of becoming overweight eat differently from thinner people. One explanation, in terms of sensitivity to affective properties of food, suggests that palatability-driven consumption is likely to be an important contributor to food intake, and therefore body weight. Extending this approach to unpalatable tastes, we examined the relationship between aversive reactions to foods and BMI. We hypothesized that people who have a high BMI will show more negative affective reactions to bitter-tasting stimuli, even after controlling for sensory perception differences. Given that hedonic reactions may influence consumption even without conscious feelings of pleasure/displeasure, the facial expressions were included in order to provide more direct access to affective systems than subjective reports. Forty adults (28 females, 12 males) participated voluntarily. Their ages ranged from 18 to 46 years (M=24.2, SD=5.8). On the basis of BMI, participants were classified as low BMI (BMI<20; n=20) and high BMI (BMI>23; n=20). The mean BMI was 19.1 for low BMI (SD=0.7) and 25.2 for high BMI participants (SD=1.8). Each subject tasted 5 mL of a grapefruit juice drink and a bitter chocolate drink. Subjects rated the drinks' hedonic and incentive value, familiarity and bitter intensity immediately after each stimulus presentation. The results indicated that high BMI participants reacted to bitter stimuli showing more profound changes from baseline in neutral and disgust facial expressions compared with low BMI. No differences between groups were detected for the subjective pleasantness and familiarity. The research here is the first to examine how affective facial reactions to bitter food, apart from taste responsiveness, can predict differences in BMI.

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Neurobiology of aversive states

Cited by 17 publications

References 182 publications

Endogenous Cholinergic Neurotransmission Contributes to Behavioral Sensitization to Morphine

Endogenous Cholinergic Neurotransmission Contributes to Behavioral Sensitization to Morphine

Aversive motivation and the maintenance of monogamous pair bonding

Facial affective reactions to bitter-tasting foods and body mass index in adults

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