Neurobiology of cancer: Interactions between nervous, endocrine and immune systems as a base for monitoring and modulating the tumorigenesis by the brain

Mravec, Boris; Gidron, Yori; Hulín, I

doi:10.1016/j.semcancer.2007.12.002

Cited by 47 publications

(30 citation statements)

References 171 publications

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“…Finally, depression is associated with altered endocrine regulation, 31 heart rate variability, 32 inflammatory markers, 33 and mortality end points, 34 which together might represent a common mechanism of disease between depression and cancer. 35 Men with a diagnosis of depressive disorder were more likely to receive ADT alone as treatment for their localized prostate cancer independent of age and clinical characteristics. ADT increases psychological distress and worsens quality of life in men with prostate cancer, 36 but its use does not appear to worsen depressive symptoms in men with prostate cancer and depression.…”

Section: Discussionmentioning

confidence: 96%

Effect of Depression on Diagnosis, Treatment, and Mortality of Men With Clinically Localized Prostate Cancer

Prasad

Eggener

Lipsitz

et al. 2014

JCO

118

110

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Purpose Although demographic, clinicopathologic, and socioeconomic differences may affect treatment and outcomes of prostate cancer, the effect of mental health disorders remains unclear. We assessed the effect of previously diagnosed depression on outcomes of men with newly diagnosed prostate cancer. Patients and Methods We performed a population-based observational cohort study using Surveillance, Epidemiology, and End Results-Medicare linked data of 41,275 men diagnosed with clinically localized prostate cancer from 2004 to 2007. We identified 1,894 men with a depressive disorder in the 2 years before the prostate cancer diagnosis and determined its effect on treatment and survival. Results Men with depressive disorder were older, white or Hispanic, unmarried, resided in nonmetropolitan areas and areas of lower median income, and had more comorbidities (P < .05 for all), but there was no variation in clinicopathologic characteristics. In adjusted analyses, men with depressive disorder were more likely to undergo expectant management for low-, intermediate-, and high-risk disease (P ≤ .05, respectively). Conversely, depressed men were less likely to undergo definitive therapy (surgery or radiation) across all risk strata (P < .01, respectively). Depressed men experienced worse overall mortality across risk strata (low: relative risk [RR], 1.86; 95% CI, 1.48 to 2.33; P < .001; intermediate: RR, 1.25; 95% CI, 1.06 to 1.49; P = .01; high: RR, 1.16; 95% CI, 1.03 to 1.32; P = .02). Conclusion Men with intermediate- or high-risk prostate cancer and a recent diagnosis of depression are less likely to undergo definitive treatment and experience worse overall survival. The effect of depression disorders on prostate cancer treatment and survivorship warrants further study, because both conditions are relatively common in men in the United States.

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Section: Discussionmentioning

confidence: 96%

Effect of Depression on Diagnosis, Treatment, and Mortality of Men With Clinically Localized Prostate Cancer

Prasad

Eggener

Lipsitz

et al. 2014

JCO

118

110

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“…Lower vagal tone (based on heart rate variability analysis) is associated with higher risk of 7-day mortality in patients with advanced pancreatic and other non-lung cancers [182] and in patients with colorectal, pancreatic, prostate, lung and ovarian cancer as compared to healthy individuals [183]. In addition to a role in immune and metabolic control, reflex neuronal regulation, involving the vagus nerve, of the inflammatory tumor microenvironment has been proposed [184–186]. Further studying this regulation and the role of the vagus nerve and other peripheral nerves in the complex cancer-inflammation relationship hold significant promises for new therapeutic approaches.…”

Section: Neurocircuitry and Inflammation In Obesity And Cancermentioning

confidence: 99%

Neural circuitry and immunity

2015

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Research during the last decade has significantly advanced our understanding of the molecular mechanisms at the interface between the nervous system and the immune system. Insight into bidirectional neuroimmune communication has characterized the nervous system as an important partner of the immune system in the regulation of inflammation. Neuronal pathways, including the vagus nerve-based inflammatory reflex are physiological regulators of immune function and inflammation. In parallel, neuronal function is altered in conditions characterized by immune dysregulation and inflammation. Here, we review these regulatory mechanisms and describe the neural circuitry modulating immunity. Understanding these mechanisms reveals possibilities to use targeted neuromodulation as a therapeutic approach for inflammatory and autoimmune disorders. These findings and current clinical exploration of neuromodulation in the treatment of inflammatory diseases defines the emerging field of Bioelectronic Medicine.

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“…These changes in heart rate are largely driven by vagal activity. There is accumulating evidence that parasympathetic vagal feedback circuits involving adrenergic and cholinergic pathways (Olofsson et al, 2012) infl uence tumour processes via regulation of infl ammation (De Couck et al 2012;Gidron & Ronson 2008;Golan et al 2009;Mravec et al, , 2008Mravec et al, 2009).…”

Section: Parasympathetic Nervous Systemmentioning

confidence: 99%

Review of psychotherapeutic interventions on depression in cancer patients and their impact on disease progression

Barrera

Spiegel

2014

International Review of Psychiatry

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Depression, ranging from mild to severe, is the most frequently found psychological symptom among individuals with cancer. Depression in cancer patients has been known to mitigate emotional distress, quality of life, adherence to medical treatment, and overall health outcomes. Specifically, depression has been associated with impaired immune response and with poorer survival in patients with cancer. Various studies have found that psychotherapeutic interventions are effective in reducing symptoms of depression, which in turn could affect disease progression and mortality. This paper provides updated information on psychotherapeutic interventions geared towards cancer patients suffering from depressive disorders, and its impact on disease progression. PubMed, Cochrane Library database, PsycINFO and PsycARTICLES databases were searched from January 1980 through August 2013 using key words: psychotherapy, treatment, oncology, cancer, psycho-oncology, psychosocial issues, psychosocial stress, depression, mood disorder, and psychoneuroimmunology.

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Neurobiology of cancer: Interactions between nervous, endocrine and immune systems as a base for monitoring and modulating the tumorigenesis by the brain

Cited by 47 publications

References 171 publications

Effect of Depression on Diagnosis, Treatment, and Mortality of Men With Clinically Localized Prostate Cancer

Effect of Depression on Diagnosis, Treatment, and Mortality of Men With Clinically Localized Prostate Cancer

Neural circuitry and immunity

Review of psychotherapeutic interventions on depression in cancer patients and their impact on disease progression

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