Neurobiology of emotion perception I: the neural basis of normal emotion perception

Phillips, Mary L.; Drevets, Wayne C.; Rauch, Scott L.; Lane, Richard D.

doi:10.1016/s0006-3223(03)00168-9

Cited by 1,946 publications

(1,536 citation statements)

References 123 publications

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“…The revealed areas are consistent with the proposed 'ventral system' of emotion processing (Phillips et al, 2003) for identification of the emotional significance of a stimulus, production of an affective state, and autonomic response regulation.…”

Section: Anatomical and Functional Features Of The Revealed Areassupporting

confidence: 81%

“…The significantly activated regions revealed by these single random effects contrasts, complying with regions known to be involved in emotion processing according to the literature (Phillips et al, 2003), served as regions of interest (ROI) for the subsequent conjunction analyses in which 'unknown' expectation was compared with the 'known' expectation conditions. Conjointly activated areas during the 'unknown' and the different 'known' emotion expectation conditions In order to address our main question, we performed conjunction analyses to uncover which of the 'known' emotion expectation conditions revealed activations similar to those in the 'unknown' expectation condition.…”

Section: Brain Activation During the Expectation Of Emotional Stimulimentioning

confidence: 99%

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Neural correlates of a ‘pessimistic’ attitude when anticipating events of unknown emotional valence

et al. 2007

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Since we do not know what future holds for us, we prepare for expected emotional events in order to deal with a pleasant or threatening environment. From an evolutionary perspective, it makes sense to be particularly prepared for the worst-case scenario. We were interested to evaluate whether this assumption is reflected in the central nervous information processing associated with expecting visual stimuli of unknown emotional valence. While being scanned with functional magnetic resonance imaging, healthy subjects were cued to expect and then perceive visual stimuli with a known emotional valence as pleasant, unpleasant, and neutral, as well as stimuli of unknown valence that could have been either pleasant or unpleasant. While anticipating pictures of unknown valence, the activity of emotion processing brain areas was similar to activity associated with expecting unpleasant pictures, but there were no areas in which the activity was similar to the activity when expecting pleasant pictures. The activity of the revealed regions, including bilateral insula, right inferior frontal gyrus, medial thalamus, and red nucleus, further correlated with the individual ratings of mood: the worse the mood, the higher the activity. These areas are supposedly involved in a network for internal adaptation and preparation processes in order to act according to potential or certain unpleasant events. Their activity appears to reflect a 'pessimistic' bias by anticipating the events of unknown valence to be unpleasant.

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Section: Anatomical and Functional Features Of The Revealed Areassupporting

confidence: 81%

Section: Brain Activation During the Expectation Of Emotional Stimulimentioning

confidence: 99%

Neural correlates of a ‘pessimistic’ attitude when anticipating events of unknown emotional valence

et al. 2007

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“…As the current study was based on model driven (Phillips et al, 2003) a priori hypotheses implicating differential dorsal-ventral aMPFC networks in the mediation of SA, connectivity estimates for the SA condition were evaluated in second level analyses. Statistical significance in the connectivity group analyses was determined by: (a.)…”

Section: Resultsmentioning

confidence: 99%

Self-appraisal decisions evoke dissociated dorsal—ventral aMPFC networks

2006

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The anterior medial prefrontal cortex (aMPFC) is consistently active during personally salient decisions, yet the differential contributory processes of this region along the dorsal-ventral axis are less understood. Using a self-appraisal decision-making task and functional magnetic resonance imaging, we demonstrated task-dependent connectivity of ventral aMPFC with amygdala, insula, and nucleus accumbens, and dorsal aMPFC connectivity with dorsolateral PFC and bilateral hippocampus. These aMPFC networks appear to subserve distinct contributory processes inherent to self-appraisal decisions, specifically a dorsally mediated cognitive and a ventrally mediated affective/self-relevance network.

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“…The ventral ACC appears to have an important role in the production of affective states (Phillips et al, 2003) and in the detection of socially relevant visual stimuli encountered below the threshold of 5-HTTLPR biases amygdala activity U Dannlowski et al conscious perception (Killgore and Yurgelun-Todd, 2004). Thus, it can be hypothesized that risk allele carriers might be more affectively responsive to facial emotions and bring potentially important stimuli more easily into the forefront of conscious awareness.…”

Section: Discussionmentioning

confidence: 99%

5-HTTLPR Biases Amygdala Activity in Response to Masked Facial Expressions in Major Depression

Dannlowski

Ohrmann

Bauer

et al. 2007

Neuropsychopharmacol

163

108

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The amygdala is a key structure in a limbic circuit involved in the rapid and unconscious processing of facial emotions. Increased amygdala reactivity has been discussed in the context of major depression. Recent studies reported that amygdala activity during conscious emotion processing is modulated by a functional polymorphism in the serotonin transporter gene (5-HTTLPR) in healthy subjects. In the present study, amygdala reactivity to displays of emotional faces was measured by means of fMRI at 3T in 35 patients with major depression and 32 healthy controls. Conscious awareness of the emotional stimuli was prevented via backward-masking to investigate automatic emotion processing. All subjects were genotyped for the 5-HTTLPR polymorphism. Risk allele carriers (S or L G ) demonstrated increased amygdala reactivity to masked emotional faces, which in turn was significantly correlated with life-time psychiatric hospitalization as an index of chronicity. This might indicate that genetic variations of the serotonin transporter could increase the risk for depression chronification via altering limbic neural activity on a preattentive level of emotion processing.

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Neurobiology of emotion perception I: the neural basis of normal emotion perception

Cited by 1,946 publications

References 123 publications

Neural correlates of a ‘pessimistic’ attitude when anticipating events of unknown emotional valence

Neural correlates of a ‘pessimistic’ attitude when anticipating events of unknown emotional valence

Self-appraisal decisions evoke dissociated dorsal—ventral aMPFC networks

5-HTTLPR Biases Amygdala Activity in Response to Masked Facial Expressions in Major Depression

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