Neurobiology of Reproductive Behavior, The Role of Neurogenesis

Portillo, Wendy; Nuñez, Mariana; Paredes, Raúl G.; Bedos, Marie

doi:10.1016/b978-0-12-809633-8.90713-1

Cited by 6 publications

(9 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adult neurogenesis is a plastic change observed in most vertebrate species and has been involved in several physiological processes including sexual and maternal behavior, gestation, recognition of sexual partner and offspring, cognition, memory, learning, and brain repair [ 25 – 27 ]. New cells are continually produced in the subventricular zone (SVZ), rostral migratory stream (RMS), and subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster)

et al. 2020

View full text Add to dashboard Cite

Microtus ochrogaster is a rodent with a monogamous reproductive strategy characterized by strong pair bond formation after 6 h of mating. Here, we determine whether mating-induced pair bonding increases cell proliferation in the subventricular zone (SVZ), rostral migratory stream (RMS), and dentate gyrus (DG) of the hippocampus in male voles. Males were assigned to one of the four groups: (1) control: males were placed alone in a clean cage; (2) social exposure to a female (SE m/f): males that could see, hear, and smell a sexually receptive female but where physical contact was not possible, because the animals were separated by an acrylic screen with small holes; (3) social exposure to a male (SE m/m): same as group 2 but males were exposed to another male without physical contact; and (4) social cohabitation with mating (SCM): males that mated freely with a receptive female for 6 h. This procedure leads to pair bond formation. Groups 2 and 3 were controls for social interaction. Male prairie voles were injected with 5-bromo-2′-deoxyuridine (BrdU) during the behavioral tests and were sacrificed 48 h later. Brains were processed to identify the new cells (BrdU-positive) and neuron precursor cells (neuroblasts). Our principal findings are that in the dorsal region of the SVZ, SCM and SE m/f and m/m increase the percentage of neuron precursor cells. In the anterior region of the RMS, SE m/f decreases the percentage of neuron precursor cells, and in the medial region SE m/f and m/m decrease the number of new cells and neuron precursor cells. In the infrapyramidal blade of the subgranular zone of the DG, SE m/m and SCM increase the number of new neuron precursor cells and SE m/m increases the percentage of these neurons. Our data suggests that social interaction, as well as sexual stimulation, leads to pair bonding in male voles modulating cell proliferation and differentiation to neuronal precursor cells at the SVZ, RMS, and DG.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster)

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Consistently, Smith and collaborators reported that female vole exposure to non-family related males increases cell proliferation in the RMS and enhances the commitment to the neuronal lineage ( Smith et al, 2001 ). Similarly, female rats that mated in 4 or 10 sessions (with behavioral tests applied every 5 days) showed an increase in the neuronal lineage differentiation in the MOB ( Alvarado-Martínez and Paredes, 2018 ; Portillo et al, 2019 ). Moreover, exposure to male odors increases newborn cells in the MOB ( Mak et al, 2007 ; Larsen et al, 2008 ).…”

Section: Discussionmentioning

confidence: 93%

Pair-bonding and social experience modulate new neurons survival in adult male and female prairie voles (Microtus ochrogaster)

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Many studies indicate that when subjects (males or females) pace the sexual interaction a reward state is induced that ensures that the behavior will be repeated in the future (reviewed in Paredes, 2014). Moreover, mating under pacing conditions induces the formation of new cells and neurons in the olfactory bulbs (OBs) and dentate gyrus of the hippocampus indicative of permanent plastic changes after mating (for a review see Bedos et al, 2018; Portillo et al, 2019).…”

Section: Motivational Drive In Rodentsmentioning

confidence: 99%

Motivational Drive in Non-copulating and Socially Monogamous Mammals

Portillo

Paredes

2019

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

Motivational drives guide behaviors in animals of different species, including humans. Some of these motivations, like looking for food and water, are crucial for the survival of the individual and hence for the preservation of the species. But there is at least another motivation that is also important for the survival of the species but not for the survival of the individual. Undoubtedly, sexual motivation is important for individuals to find a mate and reproduce, thus ensuring the survival of the species. In species with sexual reproduction, when males find a female in the appropriate hormonal conditions, they will display sexual behavior. However, some healthy males do not mate when they have access to a sexually receptive female, even though they are repeatedly tested. These non-copulating (NC) individuals have been reported in murine, cricetid and ungulates. In humans this sexual orientation is denominated asexuality. Asexual individuals are physically and emotionally healthy men and women without desire for sexual intercourse. Different species have developed a variety of strategies to find a mate and reproduce. Most species of mammals are polygamous; they mate with one or several partners at the same time, as occur in rats, or they can reproduce with different conspecifics throughout their life span. There are also monogamous species that only mate with one partner. One of the most studied socially monogamous species is the Prairie vole. In this species mating or cohabitation for long periods induces the formation of a long-lasting pair bond. Both males and females share the nest, show a preference for their sexual partner, display aggression to other males and females and display parental behavior towards their pups. This broad spectrum of reproductive strategies demonstrates the biological variability of sexual motivation and points out the importance of understanding the neurobiological basis of sexual motivational drives in different species.

show abstract

Neurobiology of Reproductive Behavior, The Role of Neurogenesis

Cited by 6 publications

References 64 publications

Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster)

Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster)

Pair-bonding and social experience modulate new neurons survival in adult male and female prairie voles (Microtus ochrogaster)

Motivational Drive in Non-copulating and Socially Monogamous Mammals

Contact Info

Product

Resources

About