Neurobiology of Stress-Induced Tinnitus

Szczepek, Agnieszka J.; Mazurek, Birgit

doi:10.1007/7854_2020_215

Cited by 20 publications

(13 citation statements)

References 131 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The deterioration of sleep patterns increases the prevalence of sleep disorders in the elderly, making it more difficult to fall or remain asleep (Gulia and Kumar, 2018). Sleep deprivation leads to the dysregulation of the circadian rhythm of cortisol and impaired executive function, impairing the ability to regulate or suppress anxiety symptoms (Chance Nicholson and Pfeiffer, 2021;Szczepek and Mazurek, 2021). As generalized anxiety disorder has both subjective sleep disturbance and sleep architecture changed, thus sleep disturbance may be one of its etiologies (Cox and Olatunji, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…The causes of tinnitus are complex, occupational or recreational noise exposure are clearly associated with tinnitus, and tinnitus can develop as a result of increased life stress (Kim et al, 2015;Rhee et al, 2020;Szczepek and Mazurek, 2021). Age-related hearing loss and hyperacusis have been linked to tinnitus, which was found to be more common and severe as people aged (Gallus et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Associations between sleep disorders and anxiety in patients with tinnitus: A cross-sectional study

Wang

Cha

et al. 2022

Front. Psychol.

View full text Add to dashboard Cite

ObjectiveTo investigate the characteristics of sleep disorders and anxiety in patients with tinnitus, their influencing factors, and the role of sleep disorders as mediators.MethodsThe general conditions and disease characteristics of 393 patients with tinnitus presented to the Changzheng Hospital of the Naval Medical University from 2018 to 2021 were collected. All patients accepted questionnaires such as Tinnitus Handicap Inventory (THI), Pittsburgh Sleep Quality Index (PSQI) and Self-rating Anxiety Scale (SAS), and then the characteristics and the influencing factors of sleep disorders and anxiety were analyzed.ResultsAmong the 393 tinnitus patients, 213 cases (54.19%) were diagnosed with sleep disorders, and 78 cases (19.85%) were diagnosed with anxiety, including 25 men (32.1%) and 53 women (67.9%). Binary regression showed that gender, hearing loss, tinnitus severity, and sleep disorders severity were positively associated with anxiety. Multiple logistic regression analysis showed that female gender (OR = 2.526, P = 0.008), hearing loss (OR = 2.901, P = 0.003, tinnitus severity (OR = 1.863, P = 0.003) and sleep disorders (OR = 2.510, P = 0.001) were the independent risk factors of anxiety. The mediating effect of sleep disorders between tinnitus severity and anxiety accounted for 27.88% of the total effect size.ConclusionFemales patients with hearing loss, moderate to severe tinnitus, and sleep disorders were at greater risk for anxiety, with sleep disorders partially mediating the anxiety associated with tinnitus.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Associations between sleep disorders and anxiety in patients with tinnitus: A cross-sectional study

Wang

Cha

et al. 2022

Front. Psychol.

View full text Add to dashboard Cite

show abstract

“…In addition to the potential effects of SARS-CoV-2 infection on the already existing tinnitus, the pandemic situation's influence on tinnitus patients should be considered. Patients with chronic tinnitus are known to react to psychological burden or emotional stress with worsening tinnitus symptoms (17)(18)(19)(20), and the situation created by the pandemic can be viewed as a stressor (21)(22)(23)(24)(25).…”

Section: Laterality Of Tinnitusmentioning

confidence: 99%

Long-Term Effects of COVID-19 and the Pandemic on Tinnitus Patients

et al. 2022

Self Cite

View full text Add to dashboard Cite

This study aimed to explore the effect of COVID-19 and the pandemic period on the tinnitus-related complaints of patients with chronic tinnitus. Ninety-six patients who were diagnosed with chronic tinnitus before the pandemic were enrolled in this study. Before the pandemic and in January 2022, all patients used the Visual Analog Scale (VAS) to assess tinnitus loudness, annoyance, and effect on everyday life, sleep, and concentration. Additionally, patients filled the Tinnitus Handicap Inventory (THI) and the Hyperacusis Questionnaire (HQ). In the entire cohort, tinnitus loudness, annoyance, and tinnitus-induced difficulties with concentration as well as THI and HQ scores increased significantly during the two pandemic years. Thirty-seven tinnitus patients contracted COVID-19 between March 2020 and January 2022. These patients were asked to list leading COVID-19 symptoms, changes in tinnitus complaints during and after the disease, and whether their hearing abilities were affected. Three patients in the COVID-19 group confirmed worsening their hearing abilities. There was no decrease in the tinnitus complaint during COVID-19, 24.3% of the infected patients reported exacerbation of tinnitus, and 75.7% said tinnitus remained the same. In the COVID-19-negative group, 13.5% reported tinnitus decrease during the pandemic, 57.6% said it remained the same, and 28.8% reported exacerbation of tinnitus. When split into infected and non-infected groups, a significant increase in tinnitus loudness, tinnitus effect on concentration, and THI scores were seen only in patients who contracted COVID-19, while hyperacusis worsened significantly (p < 0.05) only in COVID-19-negative tinnitus patients. Despite significant differences within the groups, there were no differences found between the groups. This study points to possible different effects of the infection with SARS-CoV-2 and the pandemic period on patients with chronic tinnitus. It also provides evidence for deterioration of preexisting tinnitus as a possible long-term effect of COVID-19.

show abstract

“…Studies have shown a strong correlation (∼32% of 9,756 participants) between HL and different types of daily stressors like occupational, poverty, long-term illness, lack of sleep, and higher burnout [ 57 ]. Also, the responses to stress via the hypothalamic-pituitary-adrenal (HPA) axis have been implicated in HL and various brain diseases [ 58 ]. The pathology may be linked to the release of cortisol and an imbalance of the N -methyl- d -aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the cochlea that can cause excess glutamate and glycine release, followed by excitotoxicity, and altered gene expression in the cochlea and the brain as described in Figure 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Stress can induce inflammation or hypoxia in the hair cell by affecting the epithelial cells in the brain to induce immune responses and cellular infiltration [ 46 ]. Stress-induced inflammation or hypoxia in the cochlea has been shown to be modulated by the macrophages [ 58 ]. Besides, virus-triggered inflammation of the meninges with subsequent spread to the cochlea could initiate the pathological processes that include cytokines (interleukin 1-beta [IL-1beta], IL-6,), overproduction of ROS, inducible nitric oxide synthase (iNOS), and tumour necrosis factor-alpha.…”

Section: Discussionmentioning

confidence: 99%

Hearing loss and brain disorders: A review of multiple pathologies

et al. 2021

View full text Add to dashboard Cite

Several causative factors are associated with hearing loss (HL) and brain disorders. However, there are many unidentified disease modifiers in these conditions. Our study summarised the most common brain disorders associated with HL and highlighted mechanisms of pathologies. We searched the literature for published articles on HL and brain disorders. Alzheimer’s disease/dementia, Parkinson’s disease, cognitive impairment, autism spectrum disorder, ataxia, epilepsy, stroke, and hypoxic-ischaemic encephalopathy majorly co-interact with HL. The estimated incidence rate was 113 per 10,000 person-years. Genetic, epigenetic, early life/neonatal stress, hypoxia, inflammation, nitric oxide infiltration, endoplasmic reticulum stress, and excess glutamate were the distinguished modifiers identified. Various mechanisms like adhesion molecules, transport proteins, hair cell apoptosis, and neurodegeneration have been implicated in these conditions and are serving as potential targets for therapies. To improve the quality of life of patients, these understandings will improve clinical diagnoses and management of HL and brain disorders.

show abstract

Neurobiology of Stress-Induced Tinnitus

Cited by 20 publications

References 131 publications

Associations between sleep disorders and anxiety in patients with tinnitus: A cross-sectional study

Associations between sleep disorders and anxiety in patients with tinnitus: A cross-sectional study

Long-Term Effects of COVID-19 and the Pandemic on Tinnitus Patients

Hearing loss and brain disorders: A review of multiple pathologies

Contact Info

Product

Resources

About