Neurobiology of zinc and its role in neurogenesis

Kumar, Vijay; Kumar, Ashok; Singh, Kritanjali; Avasthi, Kapil Kumar; Kim, Jong-Joo

doi:10.1007/s00394-020-02454-3

Cited by 49 publications

(32 citation statements)

References 119 publications

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“…Also, neurogenesis is controlled by metal ion concentrations such as Fe, Cu, and Zn. In ASD, it is typically hindered due to effects in various pathways ( Wang et al, 2019 ; Kumar et al, 2021 ). Zn deficiency has been shown to reduce the proliferative development of neuronal stem cells, leading to decreased cell survival ( Pfaender et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

“…Zn deficiency has been shown to reduce the proliferative development of neuronal stem cells, leading to decreased cell survival ( Pfaender et al, 2016 ). Even marginal Zn deficiency affects neurogenesis by altering the number of neurons and reducing neuronal specification ( Kumar et al, 2021 ). Altered neurogenesis has also been implicated in ASD.…”

Section: Introductionmentioning

confidence: 99%

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The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders

Stanton

Malijauskaite

McGourty

et al. 2021

Front. Mol. Neurosci.

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Metal dyshomeostasis plays a significant role in various neurological diseases such as Alzheimer’s disease, Parkinson’s disease, Autism Spectrum Disorders (ASD), and many more. Like studies investigating the proteome, transcriptome, epigenome, microbiome, etc., for years, metallomics studies have focused on data from their domain, i.e., trace metal composition, only. Still, few have considered the links between other “omes,” which may together result in an individual’s specific pathologies. In particular, ASD have been reported to have multitudes of possible causal effects. Metallomics data focusing on metal deficiencies and dyshomeostasis can be linked to functions of metalloenzymes, metal transporters, and transcription factors, thus affecting the proteome and transcriptome. Furthermore, recent studies in ASD have emphasized the gut-brain axis, with alterations in the microbiome being linked to changes in the metabolome and inflammatory processes. However, the microbiome and other “omes” are heavily influenced by the metallome. Thus, here, we will summarize the known implications of a changed metallome for other “omes” in the body in the context of “omics” studies in ASD. We will highlight possible connections and propose a model that may explain the so far independently reported pathologies in ASD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders

Stanton

Malijauskaite

McGourty

et al. 2021

Front. Mol. Neurosci.

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“…Zn is essential for embryogenesis and neurogenesis. Deficiency in this element is associated with fetal growth retardation and neurodegenerative disorders (28,(49)(50)(51). It may also promote antimicrobial activity (15,17).…”

Section: Discussionmentioning

confidence: 99%

Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

et al. 2021

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The growth and development of the fetus is a complex phenomenon that can be influenced by several variables. High quantities of heavy metal ions in the amniotic fluid have been linked to poor health, especially in industrial, polluted and poor areas. The aim of the present study was to assess the differences in the concentration of these ions between preterm (weeks 15-37) and term pregnancies (starting at week 37). Another objective was to compare pregnancies from two cities with different industry levels. Two sample lots from two Romanian cities were analyzed. A total of 100 patients from Timisoara were compared with 60 from Petrosani, a heavy industry city in Romania. Demographic data were collected, and amniocentesis was performed on all women. Lead (Pb), copper (Cu), nickel (Ni), cadmium (Cd), arsenic (As), iron (Fe) and zinc (Zn) concentrations were assessed. Descriptive and analytical statistics were performed using the Mann-Whitney U test for non-parametric data and the Fisher's exact test for categorical data. In addition, categorical data was represented graphically. In the Timisoara cohort, the differences in heavy metal concentrations between preterm and term pregnancies were not statistically significant. In the Petrosani cohort, however, the concentrations of Zn (P=0.02606) and Cd (P=0.01512) were higher in preterm than in term pregnancies. When comparing the two cohorts as a whole, the concentration of Pb (P=0.04513), Cd (P=0.00002), As (P=0.03027) and Zn (P<0.00001) were higher in the patients from Petrosani than in those from Timisoara. Only Cu concentrations were higher in the Timisoara cohort (P<0.00001). The concentrations of Ni (P=0.78150) and Fe (P=0.44540) did not differ statistically. Thus, amniocentesis is an important diagnostic and exploratory tool in determining differences in the concentrations of elements such as heavy metal ions. Research over a longer period of time should be carried out to examine the relation between heavy metal ions concentration and possible postnatal health outcomes.

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“…Lebensjahr durchgeführt, so können die Entwicklungsstörungen behoben werden [91] Zink Zink kommt in nahezu allen Hirnarealen, vor allem in presynaptischen Vesikeln und glutaminergen Neuronen in freier Form vor, besonders reichlich im Hippocampus [92]. Hier ist für die lebenslange Regulation der Neurogenese wie auch Eisen, Vitamin D und A essenziell [93]. Zinkdefizite hemmen die Stammzellproliferation Hippocampusentwicklung und die adulte Neurogenese [94] bei einem subklinischen Zinkmangel wurde bei Kindern aus armen Haushalten ein negativer Einfluss auf Gedächtnis und Aufmerksamkeit beschrieben [95,96] Zinkmangel Kinder mit Jodmangel haben einen signifikant niedrigeren IQ-Score [100].…”

Section: Bedeutung Für Gehirnentwicklungunclassified

Ernährungsarmut bei Kindern – Ursachen, Folgen, COVID-19

Biesalski

2021

Aktuelle Ernährungsmedizin

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ZusammenfassungDie SARS-CoV-2-Pandemie hat zu lang anhaltenden Beschränkungen geführt, die vor allem Kinder in armen Familien besonders betrafen. Nicht nur der psychische Druck, die fehlenden sozialen Kontakte, die immer wieder kommuniziert werden, sondern auch eine unzureichende Ernährung hat Folgen für die Kinder. Letzteres wird aber bisher übersehen, da schwer vorstellbar. Kinder aus armen Verhältnissen sind bereits vor den Schließungen der Schulen und damit auch der Schulmensen in vielen Fällen nicht ausreichend ernährt. Eine gesunde Ernährung, wie sie Kinder vor allem in den Entwicklungsphasen brauchen, kann mit den verfügbaren Mitteln des ALGII nicht finanziert werden. Kommt eine Lockdown-Situation dazu, so wird der finanzielle Rahmen für Lebensmittel noch enger und die ausfallende Schulverpflegung verschärft die Situation einer Mangelernährung bei Kindern aus armen Verhältnissen. In Deutschland sind dies derzeit 21 %, die vorwiegend bei alleinerziehenden Müttern (53 %) leben. Die Folgen sind auch in Deutschland sichtbar, Wachstumsverzögerung und eingeschränkte kognitive Entwicklung. Ursache sind fehlende Mikronährstoffe (Eisen, Zink, Jod, Vitamin D), die für die körperliche und kognitive Entwicklung gebraucht werden. Die Erhöhung des Tagessatzes für Ernährung (4,01 €) auf 5,50 € ist ebenso eine dringend gebotene Maßnahme, wie eine Alternative zur Schulspeisung, wenn die Schulen geschlossen sind.

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Neurobiology of zinc and its role in neurogenesis

Cited by 49 publications

References 119 publications

The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders

The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders

Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output

Ernährungsarmut bei Kindern – Ursachen, Folgen, COVID-19

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