Neuroblastoma and Whole Genome Searches

Capasso, Mario

doi:10.5772/34582

Contemporary Pediatrics 2012

DOI: 10.5772/34582

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Neuroblastoma and Whole Genome Searches

Mario Capasso¹

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2016

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An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma

et al. 2016

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BackgroundThe prognosis of children with metastatic stage 4 neuroblastoma (NB) has remained poor in the past decade.Patients and methodsUsing microarray analyses of 342 primary tumors, we here developed and validated an easy to use gene expression-based risk score including 18 genes, which can robustly predict the outcome of stage 4 patients.ResultsThis classifier was a significant predictor of overall survival in two independent validation cohorts [cohort 1 (n = 214): P = 6.3 × 10−5; cohort 2 (n = 27): P = 3.1 × 10−2]. The prognostic value of the risk score was validated by multivariate analysis including the established markers age and MYCN status (P = 0.027). In the pooled validation cohorts (n = 241), integration of the risk score with the age and/or MYCN status identified subgroups with significantly differing overall survival (ranging from 35 to 100 %).ConclusionTogether, the 18-gene risk score classifier can identify patients with stage 4 NB with favorable outcome and may therefore improve risk assessment and treatment stratification of NB patients with disseminated disease.Electronic supplementary materialThe online version of this article (doi:10.1186/s12967-016-0896-7) contains supplementary material, which is available to authorized users.

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An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma

et al. 2016

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Neuroblastoma and Whole Genome Searches

Cited by 1 publication

References 51 publications

An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma

An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma

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