Neuroblastoma in Turkish Children

Aydn, Guzide Burça; Kutluk, M. Tezer; Yalçn, Bilgehan; Büyükpamukçu, Münevver; Kale, Gülsev; Varan, Ali; Akyüz, Canan; Şenocak, Mehmet Emìn; Büyükpamukçu, Nebìl

doi:10.1097/mph.0b013e3181a6dea4

Cited by 25 publications

(12 citation statements)

References 28 publications

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“…Compared with the current study, the reported studies, showed higher incidence of infants (45%) [13] and lower male to female ratio (1.3: 1) [14] and this may be explained by higher total number of patients (n = 500 - 594) in their studies.…”

Section: Discussioncontrasting

confidence: 84%

Treatment results and prognostic factors of pediatric neuroblastoma: a retrospective study

Elsayed¹,

Ali²,

Sayed³

et al. 2010

Int Arch Med

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BackgroundWe conducted a retrospective analysis to investigate treatment results and prognostic factors of pediatric neuroblastoma patients.MethodsThis retrospective study was carried out analyzing the medical records of patients with the pathological diagnosis of neuroblastoma seen at South Egypt Cancer Institute, Assiut University during the period from January 2001 and January 2010. After induction chemotherapy, response according to international neuoblastoma response criteria was assessed. Radiotherapy to patients with residual primary tumor was applied. Overall and event free survival (OAS and EFS) rates were estimated using Graphed prism program. The Log-rank test was used to examine differences in OAS and EFS rates. Cox-regression multivariate analysis was done to determine the independent prognostic factors affecting survival rates.ResultsFifty three cases were analyzed. The median follow-up duration was 32 months and ranged from 2 to 84 months. The 3-year OAS and EFS rates were 39.4% and 29.3% respectively. Poor prognostic factors included age >1 year of age, N-MYC amplification, and high risk group. The majority of patients (68%) presented in high risk group, where treatment outcome was poor, as only 21% of patients survived for 3 year.ConclusionMultivariate analysis confirmed only the association between survival and risk group. However, in univariate analysis, local radiation therapy resulted in significant survival improvement. Therefore, radiotherapy should be given to patients with residual tumor evident after induction chemotherapy and surgery. Future attempts to improve OAS in high risk group patients with aggressive chemotherapy and bone marrow transplantation should be considered.

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Section: Discussioncontrasting

confidence: 84%

Treatment results and prognostic factors of pediatric neuroblastoma: a retrospective study

Elsayed¹,

Ali²,

Sayed³

et al. 2010

Int Arch Med

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“…1 This potentially introduces batch effects and other variations that are largely unpredictable, including adoption of new microarray chip designs based on manufacturer design improvements. 17, 18, 19 We conduct CV for each model on the training set, followed by EV on the validation set.…”

Section: Methodsmentioning

confidence: 99%

“…Although retrospective analysis of neuroblastoma statistics indicates an overall improvement of treatment success, mortality rates for advanced-stage neuroblastoma are still high. 18, 19 The International Neuroblastoma Risk Group has established a set of clinical factors for predicting disease recurrence and survival. These clinical factors include disease stage, age of the patient at diagnosis, histological features and several genetic markers.…”

Section: Introductionmentioning

confidence: 99%

k-Nearest neighbor models for microarray gene expression analysis and clinical outcome prediction

Jones²,

et al. 2010

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In the clinical application of genomic data analysis and modeling, a number of factors contribute to the performance of disease classification and clinical outcome prediction. This study focuses on the k-nearest neighbor (KNN) modeling strategy and its clinical use. Although KNN is simple and clinically appealing, large performance variations were found among experienced data analysis teams in the MicroArray Quality Control Phase II (MAQC-II) project. For clinical end points and controls from breast cancer, neuroblastoma and multiple myeloma, we systematically generated 463 320 KNN models by varying feature ranking method, number of features, distance metric, number of neighbors, vote weighting and decision threshold. We identified factors that contribute to the MAQC-II project performance variation, and validated a KNN data analysis protocol using a newly generated clinical data set with 478 neuroblastoma patients. We interpreted the biological and practical significance of the derived KNN models, and compared their performance with existing clinical factors.

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“…In our series, 95% of the PNTs occurred in children under five years of age, and of those, half occurred in children less than one year old. Based on the literature (18,19), girls are more likely to suffer from PNTs than boys are; however, in our research, there were slightly more boys than girls with PNTs (1.15: 1).…”

Section: Discussionmentioning

confidence: 46%

Clinical Characteristics of Peripheral Neuroblastic Tumors in Children: A Single-Center Experience of 43 Cases

Lin

Chen

et al. 2018

Iran J Pediatr

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Background: The true incidence of peripheral neuroblastic tumors (PNTs) in children is unknown. This study aims to review and analyze clinical data on the diagnosis and management of pediatric PNTs. Methods: Between 2007 and 2016, a total of 43 pediatric patients admitted to our institute with PNTs were reviewed. Results: The series comprised of 23 males and 20 females with a median age of 1.2 years old. Among the 43 PNTs, 26 tumors originated from the abdomen, 13 from the thorax and four from other primary sites. A total of 16 tumors were identified in routine examinations. Abdominal pain and distension were the main clinical manifestations of abdominal PNTs, while coughing was the most frequent presenting symptom of thoracic PNTs. Elevated vanillylmandelic acid level in the urine over 24 hours was observed in 18 neuroblastoma cases and three ganglioneuroblastoma cases. Neuroblastoma was the most common type of PNT that was reported in 30 (69.8%) patients, followed by ganglioneuroblastoma, which was diagnosed in 11 (25.6%) patients. Only 2 (4.6%) patients were diagnosed with ganglioneuroma. A total of 12 cases were stage, six cases were stage II, three cases were stage III, 18 cases were stage IV, and four cases were stage IVs. The overall two year survival rate was 62.9%, which was related to pathological type, Shimada classification, stage, and primary site. Conclusions: Pediatric PNTs have different clinical characteristics and outcomes. Imaging and laboratory data may be useful for the differentiation of PNTs. This study will help pediatric surgeons be aware of the possible manifestations of PNTs in children.

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Neuroblastoma in Turkish Children

Cited by 25 publications

References 28 publications

Treatment results and prognostic factors of pediatric neuroblastoma: a retrospective study

Treatment results and prognostic factors of pediatric neuroblastoma: a retrospective study

k-Nearest neighbor models for microarray gene expression analysis and clinical outcome prediction

Clinical Characteristics of Peripheral Neuroblastic Tumors in Children: A Single-Center Experience of 43 Cases

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