2014
DOI: 10.1158/1078-0432.ccr-13-3464
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Neuroblastoma Killing Properties of Vδ2 and Vδ2-Negative γδT Cells Following Expansion by Artificial Antigen-Presenting Cells

Abstract: Purpose: The majority of circulating human gdT lymphocytes are of the Vg9Vd2 lineage, and have T-cell receptor (TCR) specificity for nonpeptide phosphoantigens. Previous attempts to stimulate and expand these cells have therefore focused on stimulation using ligands of the Vg9Vd2 receptor, whereas relatively little is known about variant blood gdT subsets and their potential role in cancer immunotherapy.Experimental Design: To expand the full repertoire of gdT without bias toward specific TCRs, we made use of … Show more

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Cited by 93 publications
(111 citation statements)
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“…The mechanisms responsible for activating Vδ2 + T cells are better understood than those of Vδ1 + T cells, and therefore the Vδ2 + subset has been more extensively investigated for immunotherapy. Functional responses of Vδ2 + T cells can be initiated by at least 3 distinct recognition pathways: (a) via the TCR, (b) via natural killer (NK) family receptors such as NKG2D, and (c) via Fc receptor (CD16) binding to antibody-coated target cells (10). Each of these pathways may facilitate their antitumor responses.…”
Section: Introductionmentioning
confidence: 99%
“…The mechanisms responsible for activating Vδ2 + T cells are better understood than those of Vδ1 + T cells, and therefore the Vδ2 + subset has been more extensively investigated for immunotherapy. Functional responses of Vδ2 + T cells can be initiated by at least 3 distinct recognition pathways: (a) via the TCR, (b) via natural killer (NK) family receptors such as NKG2D, and (c) via Fc receptor (CD16) binding to antibody-coated target cells (10). Each of these pathways may facilitate their antitumor responses.…”
Section: Introductionmentioning
confidence: 99%
“…For Vd2 + gdT cell cytotoxicity against neuroblastoma, co-stimulation is known to occur in part through receptors, such as NKG2D, which are ligated by danger-associated molecules, such as MIC-A and MIC-B, but can also be provided via Fcg receptors within the context of an opsonized target cell, as we have previously shown. 19,20 The degree of antibody-dependent cell-mediated cytotoxicity (ADCC) was proportional to the degree of antigen-antibody-CD16 interaction. 19,20 Neuroblastoma cells have been reported to evade NKG2D-mediated immune destruction through downregulation of NKG2D ligands or by secretion of receptor-blocking soluble ligands.…”
Section: Introductionmentioning
confidence: 99%
“…19,20 The degree of antibody-dependent cell-mediated cytotoxicity (ADCC) was proportional to the degree of antigen-antibody-CD16 interaction. 19,20 Neuroblastoma cells have been reported to evade NKG2D-mediated immune destruction through downregulation of NKG2D ligands or by secretion of receptor-blocking soluble ligands. 21,22 This has been demonstrated to be an important escape mechanism against NK cellmediated killing of neuroblastoma.…”
Section: Introductionmentioning
confidence: 99%
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“…In this issue of Clinical Cancer Research, the articles by Deniger and colleagues (1) and by Fisher and colleagues (2) report on a novel process for scaling up in vitro expansion of polyclonal gd T-cell lines with killing activity against cancer cells for clinical use. T-cell therapy to treat cancer has been the focus of much interest in the past years and led to the recent success of chimeric antigen receptors-expressing T cells (reviewed in ref.…”
mentioning
confidence: 99%