Neurobrucellosis

Deeb, S. M. Al; Yaqub, Basim A.; Sharif, Hassan; Phadke, Jayant G.

doi:10.1212/wnl.39.4.498

Cited by 140 publications

(106 citation statements)

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“…Meningitis has been reported to be the most frequent presentation, occurring in about 50% of the cases [13]. In our study, 16 cases (80%) had evidence of meningeal infection, as indicated by pleocytosis, elevated protein level in the CSF and usually hypoglycorrhachia.…”

Section: Discussionsupporting

confidence: 48%

Neurobrucellosis: report of a rare disease in 20 Iranian patients referred to a tertiary hospital

Ranjbar¹,

Rezaiee²,

Hashemi³

et al. 2009

East Mediterr Health J

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We reviewed the clinical manifestations and outcome of 20 cases of neurobrocellosis out of 1375 patients with brucellosis admitted to the infectious diseases ward of a tertiary hospital in Hamedan, Islamic Republic of Iran. Of the 20 cases, 12 had meningitis (acute and subacute), 4 had meningo encephalitis, 2 had myelopathy, 1 had polyradiculopathy and 1 had meningovascular complications manifested by stroke. The most prevalent symptoms were headache (75%), vomiting and fever (50%) and unconsciousness (35%). Among 20 neurobrucellosis patients, 1 died and the other 19 recovered; 14 fully recovered and 5 patients had residual neurological deficits. In endemic areas, the disease should be ruled out in all patients who develop unexplained neurological symptoms.

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Section: Discussionsupporting

confidence: 48%

Neurobrucellosis: report of a rare disease in 20 Iranian patients referred to a tertiary hospital

Ranjbar¹,

Rezaiee²,

Hashemi³

et al. 2009

East Mediterr Health J

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“…Thus, the presentation of NB is diverse (6). The most common type of NB affecting the CNS is chronic meningoencephalitis in which lymphocytic pleocytosis and high protein levels are detected in the CSF (8). Because Brucella is a slow-growing bacterium, CSF and blood cultures can be negative, so the diagnosis is generally made by serological methods.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, splenial T2-hyperintensity in our patient was thought to result from an alternative mechanism. CNS demyelination can be a rare feature of NB (6,(8)(9)(10). In 1963, Fincham et al reported that the white matter changes in NB were sequelae of demyelination, as confirmed by pathologic study (9).…”

Section: B Amentioning

confidence: 97%

An unusual case of neurobrucellosis presenting with unilateral abducens nerve palsy: clinical and MRI findings

Özkavukçu¹,

Tuncay²,

Selçuk³

et al. 2008

Diagn Interv Radiol

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“…Studies have demonstrated that 4-13% of patients have neurological involvement [5,6]. Neurological involvement has been reported in both the acute or chronic period of brucellosis.…”

Section: Introductionmentioning

confidence: 99%

“…Neurological involvement has been reported in both the acute or chronic period of brucellosis. Central nervous system involvements of meningitis, meningoencephalitis, myelitis, arachnoiditis, brain abscess and epidural abscess may be presented [5][6][7]. Peripheral nervous system involvements of polyradiculoneuritis, cranial nerve neuropathies and peripheral neuropathies have been reported.…”

Section: Introductionmentioning

confidence: 99%

Frequency of subclinical peripheral neuropathy in cases of untreated brucellosis

Sanivar

Ozlece

Huseyinoglu

et al. 2017

J Infect Dev Ctries

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Introduction: Brucellosis is a common zoonotic disease in some areas of the world. It may affect several organs and is known to involve the nervous system in 2.7-17.8% of affected patients. During the progression of brucellosis, peripheral neuropathies (PNs) have been reported. However, there are few studies investigating the presence of subclinical neuropathy in asymptomatic patients. In our study, we aimed to evaluate the presence of peripheral neuropathy using electrophysiological methods in newly-diagnosed untreated brucellosis patients. Methodology: The study included a control group of 60 healthy volunteers and 60 untreated brucellosis patients with a positive result of 1/160 or above on a brucella tube agglutination test. The patient and control groups were evaluated by electrophysiological methods. Results: In the patient group, all investigated motor nerves had slower average motor conduction speeds, reduced compound muscle action potential (CMAP) amplitudes and delayed F response and terminal latency compared to the control group. The sural nerve sensory conduction speed was slower and the sensory nerve action potential (SNAP) was found to be reduced. Conclusion: Among the 60 patients with acute brucellosis, 18% had sensorimotor peripheral neuropathy of widespread axonal character. Brucellosis can have many effects in the nervous system, including clinical or subclinical peripheral neuropathy in the peripheral nervous system. Brucellosis should be considered for differential diagnosis of patients with unexplained neurological and clinically relevant electrophysiological findings, especially in regions with endemic brucellosis.

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Neurobrucellosis

Cited by 140 publications

References 0 publications

Neurobrucellosis: report of a rare disease in 20 Iranian patients referred to a tertiary hospital

Neurobrucellosis: report of a rare disease in 20 Iranian patients referred to a tertiary hospital

An unusual case of neurobrucellosis presenting with unilateral abducens nerve palsy: clinical and MRI findings

Frequency of subclinical peripheral neuropathy in cases of untreated brucellosis

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