Neurochemical and behavioral effects elicited by bupropion and diethylpropion in rats

Santamarı́a, Abel; Arias, Hugo R.

doi:10.1016/j.bbr.2010.03.023

Cited by 37 publications

(29 citation statements)

References 31 publications

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“…Bupropion treatments to OVX rats did not attenuate the body weight gain, whereas the clinical data supported weight reduction in patients after bupropion use [53] . However, bupropion treatment for 15 d did not have a significant effect on body weight when compared with the control in an experimental study [54] . Therefore, further investigations are needed to compare the effect of bupropion on the body weight gain associated with menopause or other conditions.…”

Section: Effects On Bone Histopathologymentioning

confidence: 76%

The antidepressant bupropion exerts alleviating properties in an ovariectomized osteoporotic rat model

et al. 2014

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Aim: depression is a risk factor for impaired bone mass and micro-architecture, but several antidepressants were found to increase the incidence of osteoporotic fractures. in the present study we used ovariectomized (oVX) rats as a model of osteoporosis to investigate the effects of the antidepressant bupropion on the femoral bones. Methods: oVX animals were treated with bupropion (30, 60 mg·kg -1 ·d -1 ) for six weeks. bone turnover biomarkers (urinary dPd/Cr ratio, serum BALP, OC, TRAcP 5b, CTX and sRANKL levels) and inflammatory cytokines (TNF-α, IL-1β and IL-6) were determined using ELISA. inductively coupled plasma mass spectroscopy (iCP-Ms) was used to determine the femoral bone mineral concentrations. The cortical and trabecular morphometric parameters of femoral bones were determined using micro-CT scan and histopathology. Results: In OVX rats, the levels of bone turnover biomarkers and inflammatory cytokines were significantly elevated and femoral bone Ca 2+ and Po 4 3-concentrations were significantly reduced. Moreover, cortical and trabecular morphometric parameters and histopathology of femoral bones were severely altered by ovariectomy. bupropion dose-dependently inhibited the increases in bone turnover biomarkers and inflammatory cytokines. OVX rats treated with the high dose of bupropion showed normal mineral concentrations in femoral bones. The altered morphometric parameters and histopathology of femoral bones were markedly attenuated by the treatment. Conclusion: bupropion exerts osteo-protective action in oVX rats through suppressing osteoclastogenesis-inducing factors and inflammation, which stabilize the osteoclasts and decrease bone matrix degradation or resorption.

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Section: Effects On Bone Histopathologymentioning

confidence: 76%

The antidepressant bupropion exerts alleviating properties in an ovariectomized osteoporotic rat model

et al. 2014

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“…It has been already reported that BP increases locomotion of freely moving rats, probably through mechanisms involving DA reuptake inhibition and AChRs blockade [18] . In addition, BP potentiates the behavioral locomotor effects of nicotine, and vice versa, nicotine pretreatment facilitates the locomotion mediated by BP [76] .…”

Section: Figure 3 Molecular Interaction Of (R)-bp and (S)-sadu-3-72 mentioning

confidence: 95%

“…Emotional effects of BP have also been observed in social interactions in mice [15] . Moreover, BP induces locomotor stimulation, although this activity is mild [16][17][18] . BP has also been found to decrease not only nicotine but also the addictive and craving effects elicited by methamphetamine in humans [19] , and by cocaine in rodents [20] , as well as morphine-induced tolerance and dependence in rodents [21] .…”

Section: Introductionmentioning

confidence: 99%

Interaction of nicotinic receptors with bupropion: Structural, functional, and pre-clinical perspectives

Arias¹,

Biała²,

Kruk-Słomka³

et al. 2014

Receptor Clin Invest

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Besides the antidepressant activity of bupropion (BP), preclinical studies in rodents provide evidence that this compound and its hydroxyl metabolites can attenuate nicotine withdrawal, reversing both the physical and negative affective aspects of nicotine abstinence. Co-interactions of BP with nicotine or other psychostimulants influence decrease anxiety-and cognitive-related processes. BP also attenuates the reinstatement of nicotine-induced conditioned place preference in rats caused by a priming dose of nicotine, morphine, cannabinoids, or ethanol.

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“…Conversely, although dopamine signal-promoting drugs have not been rigorously tested in PTSD, a few clinical cases of psychostimulant-induced improvements have been reported, one in a woman with car accident-related PTSD after phenethylamine diethylpropion for weight loss was added to a standing dose of fluoxetine (Daly, 2000) and three in combat veterans who were prescribed methylphenidate (in one case supplemented with dextroamphetamine) (Houlihan, 2011). However, it should be noted that diethylpropion, methylphenidate, and amphetamine all increase noradrenergic as well as dopaminergic signaling (Raiteri et al, 1975;Geranton et al, 2003;Kuczenski and Segal, 2005;Arnsten, 2006;Han and Gu, 2006;Santamaria and Arias, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effect of traumatic imagery on cerebrospinal fluid dopamine and serotonin metabolites in posttraumatic stress disorder

Geracioti

Jefferson-Wilson

Baker

et al. 2013

Journal of Psychiatric Research

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Neurochemical and behavioral effects elicited by bupropion and diethylpropion in rats

Cited by 37 publications

References 31 publications

The antidepressant bupropion exerts alleviating properties in an ovariectomized osteoporotic rat model

The antidepressant bupropion exerts alleviating properties in an ovariectomized osteoporotic rat model

Interaction of nicotinic receptors with bupropion: Structural, functional, and pre-clinical perspectives

Effect of traumatic imagery on cerebrospinal fluid dopamine and serotonin metabolites in posttraumatic stress disorder

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