Neurochemical basis of interleukin 2-modified discrimination behaviour

Ho, Beng T.; Lu, Junjun; Huo, Y Y; Fan, Shu-Huai; Meyers, Christina A.; Tansey, L. Wayne; Payne, Richard; Levin, Victor A.

doi:10.1016/1043-4666(94)90059-0

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…IL‐2 potentiates novelty‐induced and the DA uptake inhibitor GBR 12909‐induced exploratory activity, suggesting that this cytokine has modulatory effects on the mesocorticolimbic DA system 32. In fact, IL‐2 potentiates discriminative stimulus effects of amphetamine and ethylketocyclazocine 33…”

Section: Interleukinsmentioning

confidence: 99%

“…32 In fact, IL-2 potentiates discriminative stimulus effects of amphetamine and ethylketocyclazocine. 33 Repeated IL-6 treatment increases sensitivity to the locomotor-stimulating effects of amphetamine. 34 Conversely, methamphetamine-induced DA and serotonin neurotoxicity were attenuated in the IL-6 knockout mice, although there was no difference in body temperature or methamphetamine levels between wild-type and the mutant animals.…”

Section: Interleukinsmentioning

confidence: 99%

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Pro‐ and Anti‐Addictive Neurotrophic Factors and Cytokines in Psychostimulant Addiction: Mini Review

Yamada

Nabeshima

2004

Annals of the New York Academy of Sciences

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Drug addiction is defined as a chronically relapsing disorder that is characterized by compulsive drug taking, inability to limit the intake, and intense drug craving. While the positive reinforcing effects of psychostimulants such as cocaine and amphetamines depend on the mesocorticolimbic dopamine system innervating nucleus accumbens, chronic drug exposure causes stable changes in the structure and function of the brain that may underlie the long-lived behavioral abnormalities in drug addiction. Recent evidence has suggested that various neurotrophic factors and cytokines are involved in the effects of psychomotor stimulants, suggesting that these factors play a role in drug addiction. In this article, a role of neurotrophic factors and cytokines in psychostimulant addiction is discussed.

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Section: Interleukinsmentioning

confidence: 99%

Section: Interleukinsmentioning

confidence: 99%

Pro‐ and Anti‐Addictive Neurotrophic Factors and Cytokines in Psychostimulant Addiction: Mini Review

Yamada

Nabeshima

2004

Annals of the New York Academy of Sciences

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“…administration of IL-6 (100). Moreover, IL-2 and interferon (IFN)-α potentiated the response induced by a psychostimulant drug in a protocol of drug discrimination behavioural effect using d -amphetamine (101,102). In contrast, TNF-α might play a different role in addiction.…”

Section: Neuroinflammation and Addiction: Role Of (Endo)cannabinoidsmentioning

confidence: 99%

Neuroinflammation as a possible link between cannabinoids and addiction

Rodrigues

Gobira

Oliveira

et al. 2013

Acta Neuropsychiatr.

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“…IL-2 potentiates the DA uptake inhibitor GBR 12909induced exploratory activity (Vanoxerine (GBR-12909) is a piperazine by-product which is a potent and selective dopamine reuptake inhibitor), suggesting that this cytokine has modulatory effects on the mesocorticolimbic DA system [30]. IL-2 potentiates discriminative stimulus effects of amphetamine and ethylketocyclazocine [31].…”

Section: Introductionmentioning

confidence: 99%

Association between opioid use disorder (tramadol) and serum level of interleukin-2

Darweesh

Agban

Mohammed

et al. 2020

Middle East Curr Psychiatry

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Background: Tramadol hydrochloride is a centrally acting analgesic drug that has turned out to be a drug of growing interest due to its success in the management of pain in humans. By considering the twin mechanism of action of tramadol, as the activation of the opioid and of the monoaminergic systems, the potential immunological effects of this drug should be considered and be evaluated. Studies show that Tramadol induces an improvement of postoperative immune suppression and increases NK cell activity, lymphocyte proliferation, and IL-2 production which may be linked to its addictive potentiality. The present study aims to investigate the possible association between opioid use disorder (tramadol) and the serum level of interleukin-2 (IL-2). An observational cross sectional study conducted at the Outpatient Clinic and

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Neurochemical basis of interleukin 2-modified discrimination behaviour

Cited by 7 publications

References 9 publications

Pro‐ and Anti‐Addictive Neurotrophic Factors and Cytokines in Psychostimulant Addiction: Mini Review

Pro‐ and Anti‐Addictive Neurotrophic Factors and Cytokines in Psychostimulant Addiction: Mini Review

Neuroinflammation as a possible link between cannabinoids and addiction

Association between opioid use disorder (tramadol) and serum level of interleukin-2

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