Neurochemical changes in the offspring of rats subjected to stressful conditions during gestation

Petropoulos, Evangelos; Lau, Christopher; Liao, CL

doi:10.1016/0014-4886(72)90228-2

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…Differences in brain amines were not apparent between PMS and C offspring at 1, 12, or 25 days of age. Some suggestion exists that the effects of PMS on brain chemistry are triggered by weaning (Petropoulos, Lau, & Liao, 1972) and may, therefore, only be apparent in animals after t h s time.…”

Section: Discussionmentioning

confidence: 99%

Aversive prenatal stimulation: Effects on behavioral, biochemical, and somatic ontogeny in the rat

Sobrian

1977

Developmental Psychobiology

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Electric foot shock administered to pregnant rats altered the ontogeny of spontaneous motor activity in their pups. Prenatally stimulated (PMS) offspring were more active than controls on Days 1-10 but less active during the 3rd postpartum week. The age of peak activity, a major developmental landmark, occurred in PMS pups around 10 days of age; in controls maximum activity was not seen until the 3rd week. This effect was independent of the gender of the offspring and the timing of the gestational stimulation. Its appearance in both cross-fostered and fostered pups indicated the prenatal origin of the effect. The maturation of spontaneous alternation behavior and several reflexes and the appearance of physical features were not affected by prenatal stimulation. Moreover, both PMS and control groups exhibited an age-related increase in brain concentrations of norepinephrine, serotonin, and 5-hydroxyindoleacetic acid. These findings indicate that spontaneous motor activity is uniquely sensitive to PMS, and as far as can be determined here, PMS produces no generalized alteration in behavioral and physical ontogeny.

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Section: Discussionmentioning

confidence: 99%

Aversive prenatal stimulation: Effects on behavioral, biochemical, and somatic ontogeny in the rat

Sobrian

1977

Developmental Psychobiology

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“…This is based on studies of the effect of long-lasting stress on organisms, in which it is stated that stress during ontogeny acts through deprivation of nutrients as well as through hormonal imbalances in the maternal body (Geist, 1978). Prenatal stress acts at the cellular level in organisms (Petropoulos et al, 1972) as well as on the population level, resulting in low-quality animals exhibiting decreased litter-size and lowered offspring viability (Geist, 1971;Vaughan, 1978).…”

Section: Female Sterility: Occurrence Of Uterine Occlusionsmentioning

confidence: 99%

Man-induced Environmental Factors in Relation to Fertility Changes in Pinnipeds

Reijnders¹

1984

Envir. Conserv.

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The possible effects of human activities (such as the release of pollutants, exploitation, and disturbance) on the reproductive performance of pinniped populations (especially of certain seals) are discussed. While there are documented cases of reproductive rates increasing in exploited seal populations, the effects of disturbance on reproduction have only been suggested on the basis of rather incidental observations.In a number of cases the decline of a pinniped population has coincided with an elevation in the level of various contaminants. In some animals, reproductive failure has been associated with high levels of contaminants in their tissues; but even in these cases, no cause-and effect relation between pollutants and altered physiological processes has been established. Clearly, far more research will be needed to elucidate these problems.

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Effects of Hypoxic Environment on Prenatal Brain Development: Recent Evidence Versus Earlier Dogma

Petropoulos

Timiras

1974

Advances in Behavioral Biology

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Neurochemical changes in the offspring of rats subjected to stressful conditions during gestation

Cited by 5 publications

References 30 publications

Aversive prenatal stimulation: Effects on behavioral, biochemical, and somatic ontogeny in the rat

Aversive prenatal stimulation: Effects on behavioral, biochemical, and somatic ontogeny in the rat

Man-induced Environmental Factors in Relation to Fertility Changes in Pinnipeds

Effects of Hypoxic Environment on Prenatal Brain Development: Recent Evidence Versus Earlier Dogma

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