Neurochemical correlates of selective neuronal loss following cerebral ischemia: role of decreased Na+, K+-ATPase activity

Nagafuji, Toshiaki; Koide, Tsuyoshi; Takato, Michiaki

doi:10.1016/0006-8993(92)90664-u

Cited by 34 publications

(11 citation statements)

References 38 publications

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“…Previous studies have reported a significant decrease in brain Na,K-ATPase activity after ischemia [6,10,42]. There are several reasons for the ischemia-induced fall in Na,KATPase activity, such as the decline of ATP content and increased production of enzymatic inhibitors [43].…”

Section: Discussionmentioning

confidence: 98%

Chronic daily administration of ethyl docosahexaenoate protects against gerbil brain ischemic damage through reduction of arachidonic acid liberation and accumulation

Cao

Yang

Hou

et al. 2007

The Journal of Nutritional Biochemistry

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Section: Discussionmentioning

confidence: 98%

Chronic daily administration of ethyl docosahexaenoate protects against gerbil brain ischemic damage through reduction of arachidonic acid liberation and accumulation

Cao

Yang

Hou

et al. 2007

The Journal of Nutritional Biochemistry

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“…The a1 and b1 isoforms are ubiquitously expressed where the a3 isoform is neuron specific [49,50]. Under hypoxia or ischemic conditions, a reduction in the activity of these channels in addition to their expression has been previously seen in the heart [51], kidney [52], and brain [53]. Therefore, to understand whether neuron-specific diversity in the expression of Na ?…”

Section: Discussionmentioning

confidence: 99%

Maternal hypertension programs increased cerebral tissue damage following stroke in adult offspring

et al. 2015

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The maternal system is challenged with many physiological changes throughout pregnancy to prepare the body to meet the metabolic needs of the fetus and for delivery. Many pregnancies, however, are faced with pathological stressors or complications that significantly impact maternal health. A shift in this paradigm is now beginning to investigate the implication of pregnancy complications on the fetus and their continued influence on offspring disease risk into adulthood. In this investigation, we sought to determine whether maternal hypertension during pregnancy alters the cerebral response of adult offspring to acute ischemic stroke. Atrial natriuretic peptide gene-disrupted (ANP(-/-)) mothers exhibit chronic hypertension that escalates during pregnancy. Through comparison of heterozygote offspring born from either normotensive (ANP(+/-WT)) or hypertensive (ANP(+/-KO)) mothers, we have demonstrated that offspring exposed to maternal hypertension exhibit larger cerebral infarct volumes following middle cerebral artery occlusion. Observation of equal baseline cardiovascular measures, cerebrovascular structure, and cerebral blood volumes between heterozygote offspring suggests no added influences on offspring that would contribute to adverse cerebral response post-stroke. Cerebral mRNA expression of endothelin and nitric oxide synthase vasoactive systems demonstrated up-regulation of Et-1 and Nos3 in ANP(+/-KO) mice and thus an enhanced acute vascular response compared to ANP(+/-WT) counterparts. Gene expression of Na(+)/K(+) ATPase channel isoforms, Atp1a1, Atp1a3, and Atp1b1, displayed no significant differences. These investigations are the first to demonstrate a fetal programming effect between maternal hypertension and adult offspring stroke outcome. Further mechanistic studies are required to complement epidemiological evidence of this phenomenon in the literature.

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“…After the occlusion of the cerebral artery, the supply of oxygen and glucose is not sufficient to power the Na/K ATPase. The increased concentration of Na + and decreased concentration of K + in the brain tissue result in necrosis 63 , 64 . The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor is a glutamate ionotropic transmembrane receptor that mediates rapid synaptic transmission in the brain 65 .…”

Section: Discussionmentioning

confidence: 99%

(S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats

Wan

Liu

Jiang

et al. 2017

Sci Rep

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Chronic cerebral hypoperfusion is a pathological state that is associated with the cognitive impairments in vascular dementia. Oxiracetam is a nootropic drug that is commonly used to treat cognitive deficits of cerebrovascular origins. However, oxiracetam is currently used as a racemic mixture whose effective ingredient has not been identified to date. In this study, we first identified that (S)-oxiracetam, but not (R)-oxiracetam, was the effective ingredient that alleviated the impairments of spatial learning and memory by ameliorating neuron damage and white matter lesions, increasing the cerebral blood flow, and inhibiting astrocyte activation in chronic cerebral hypoperfused rats. Furthermore, using MALDI-MSI and LC-MS/MS, we demonstrated that (S)-oxiracetam regulated ATP metabolism, glutamine-glutamate and anti-oxidants in the cortex region of hypoperfused rats. Altogether, our results strongly suggest that (S)-oxiracetam alone could be a nootropic drug for the treatment of cognitive impairments caused by cerebral hypoperfusion.

show abstract

Neurochemical correlates of selective neuronal loss following cerebral ischemia: role of decreased Na+, K+-ATPase activity

Cited by 34 publications

References 38 publications

Chronic daily administration of ethyl docosahexaenoate protects against gerbil brain ischemic damage through reduction of arachidonic acid liberation and accumulation

Chronic daily administration of ethyl docosahexaenoate protects against gerbil brain ischemic damage through reduction of arachidonic acid liberation and accumulation

Maternal hypertension programs increased cerebral tissue damage following stroke in adult offspring

(S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats

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