2016
DOI: 10.1016/j.pnpbp.2015.08.009
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Neurochemical factors underlying individual differences in locomotor activity and anxiety-like behavioral responses in zebrafish

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Cited by 53 publications
(31 citation statements)
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“…In zebrafish, binge-like exposure to 1% ethanol enhances tyrosine hydroxylase expression and dopamine levels in adult zebrafish brain, and indicates a role for the dopaminergic system in altered shoaling behavior as a consequence of ethanol exposure (Fernandes et al, 2015; Trans et al 2016a; 2016b). Relevant to the present study, exposure of adult zebrafish to 1% ethanol resulted in altered anxiety-like behavior that was shown to be mediated by the serotonergic system (Trans et al 2016c). While it is unclear if alterations in shoaling may also be mediated by signaling pathways such as Shh and/or RA, and if ethanol-mediated disruption of Shh signaling impairs normal development of these neurotransmitter systems, it would be of interest to investigate a possible role for Shh signaling in the development of the dopaminergic and serotonergic systems.…”
Section: Discussionmentioning
confidence: 68%
“…In zebrafish, binge-like exposure to 1% ethanol enhances tyrosine hydroxylase expression and dopamine levels in adult zebrafish brain, and indicates a role for the dopaminergic system in altered shoaling behavior as a consequence of ethanol exposure (Fernandes et al, 2015; Trans et al 2016a; 2016b). Relevant to the present study, exposure of adult zebrafish to 1% ethanol resulted in altered anxiety-like behavior that was shown to be mediated by the serotonergic system (Trans et al 2016c). While it is unclear if alterations in shoaling may also be mediated by signaling pathways such as Shh and/or RA, and if ethanol-mediated disruption of Shh signaling impairs normal development of these neurotransmitter systems, it would be of interest to investigate a possible role for Shh signaling in the development of the dopaminergic and serotonergic systems.…”
Section: Discussionmentioning
confidence: 68%
“…For example, activation of D4-receptors in the medial pre-frontal cortex potentiates fear-associated memory formation but has no impact on recall (Lauzon et al 2009; Laviolette et al 2005), whereas activation of D1-like receptors blocks recalls of previously learned fear-associated memories but has no impact on learning (Lauzon et al 2009), suggesting a double dissociation of function. Interestingly, the serotonergic (5-HT) system has also been shown to have an important role in mediating individual differences in anxiety-like responses and locomotor activity in zebrafish and exerts a minor modulatory role of the DA system (Tran et al 2016). Both behavioral laterality and aversive memory is mostly associated with modulatory action of the DA system , but the 5-HT system has a major role modulating zebrafish responses to novelty.…”
Section: Discussionmentioning
confidence: 99%
“…Likewise, (Gebauer et al 2011) observed that ethanol administration resulted in reduced anxiety in the light/dark test, but not in the novel tank diving test. In contrast with these findings, Tran and collaborators (Tran et al 2016c) reported that acute exposure to high ethanol concentration resulted in increased preference for the bottom of the test tank, and that such a variation related to alterations in brain monoamines. Specifically, alcohol-treated subjects showed reduced concentrations of the dopamine metabolite DOPAC, of serotonin and its metabolite 5-IAA (Tran et al 2016c).…”
Section: Discussionmentioning
confidence: 84%
“…In contrast with these findings, Tran and collaborators (Tran et al 2016c) reported that acute exposure to high ethanol concentration resulted in increased preference for the bottom of the test tank, and that such a variation related to alterations in brain monoamines. Specifically, alcohol-treated subjects showed reduced concentrations of the dopamine metabolite DOPAC, of serotonin and its metabolite 5-IAA (Tran et al 2016c). Thus, while the effects of ethanol on anxiety are more variable compared to those exerted by citalopram, they apparently impinge on the same neurochemical pathways modulated by citalopram.…”
Section: Discussionmentioning
confidence: 84%