Neurochemical measurements in the brains of mice infected with<i>Trypanosoma brucei brucei</i>(TREU 667)

Amole, Babatunde O.; Sharpless, Nansie S.; Wittner, Murray; Tanowitz, H. B.

doi:10.1080/00034983.1989.11812336

Cited by 14 publications

(4 citation statements)

References 22 publications

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“…In this study, we found that brain dopamine and serotonin levels increased after infection. The disturbance in dopamine and serotonin due to infection was also investigated by Amole et al (1989) after infection with T. brucei brucei , which was attributed to the production of reactive oxygen species, which cause cellular damage and lead to the pathogenesis of the disease ( Gupta et al, 2009 ).…”

Section: Discussionmentioning

confidence: 99%

Treatment of Trypanosoma evansi-Infected Mice With Eucalyptus camaldulensis Led to a Change in Brain Response and Spleen Immunomodulation

et al. 2022

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Surra is a parasitic disease caused by the eukaryotic, unicellular hemoprotozoan, Trypanosoma evansi, which affects the development of animal production and is widespread among both domestic and wild animals. As such, in this research, we studied the antiparasitic activity and the ameliorative impact of Eucalyptus camaldulensis leaf extracts (ELE) against T. evansi-induced brain injury and spleen immune response in mice. As a result, we found that ELE decreased the amount of trypanosomes in the blood and improved the weight loss caused by infection. In addition, ELE reduced the parasite-induced brain and spleen histopathological damage. The parasite affected the levels of dopamine and serotonin, but after treatment with ELE, their concentrations significantly decreased to 154 ± 7 and 258 ± 11 μg/g, respectively. We clearly observed the antioxidant activity of ELE because of its ability to increase the induced change in the brain’s total antioxidant capacity and the nitric oxide level. The histopathological changes in the spleen also improved after ELE application. Based on our results, we concluded that ELE possesses antitrypanosomal antioxidant and protective effects in the brains of mice infected with T. evansi. Additional phytochemical screening and molecular studies are required to understand the mechanism underlying the effect of ELE.

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Section: Discussionmentioning

confidence: 99%

Treatment of Trypanosoma evansi-Infected Mice With Eucalyptus camaldulensis Led to a Change in Brain Response and Spleen Immunomodulation

et al. 2022

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“…The leukoencephalitis caused by infiltrating cells is also accompanied by microglia and astrocyte activation ( 68 ). There are also changes in the monoaminergic neurotransmitters, dopamine, serotonin, and norepinephrine, in the brain during trypanosomiasis, which might contribute to the neuropsychiatric abnormalities observed in HAT ( 74 , 75 ).…”

Section: Neuroimmunology Of Human African Trypanosomiasismentioning

confidence: 99%

Neuroimmunology of Common Parasitic Infections in Africa

et al. 2022

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Parasitic infections of the central nervous system are an important cause of morbidity and mortality in Africa. The neurological, cognitive, and psychiatric sequelae of these infections result from a complex interplay between the parasites and the host inflammatory response. Here we review some of the diseases caused by selected parasitic organisms known to infect the nervous system including Plasmodium falciparum, Toxoplasma gondii, Trypanosoma brucei spp., and Taenia solium species. For each parasite, we describe the geographical distribution, prevalence, life cycle, and typical clinical symptoms of infection and pathogenesis. We pay particular attention to how the parasites infect the brain and the interaction between each organism and the host immune system. We describe how an understanding of these processes may guide optimal diagnostic and therapeutic strategies to treat these disorders. Finally, we highlight current gaps in our understanding of disease pathophysiology and call for increased interrogation of these often-neglected disorders of the nervous system.

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“…Therefore, early astrocyte activation was probably crucial in triggering the inflammatory response in the central nervous system. Also, during trypanosomiasis, the monoaminergic neurotransmitters dopamine, serotonin, and norepinephrine were altered in brain, which could be a factor in the neuropsychiatric disorders seen in HAT (Stibbs and Curtis, 1987;Amole et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Neurotropic Parasitic Infections Associated With Psychiatric Disorders: A Review Article

ELSHAFEY,

ELBAITAR

et al. 2023

Journal of the Egyptian Society of Parasitology

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Psychiatric disorders are a group of disorders characterized by a combination of changes in behavior, disturbed thoughts, emotions, and relationships with others. They are considered the 3 rd most common diseases worldwide, after malignancy and cardiovascular diseases, but the etiology of psychiatric disorders is still questionable. Besides, biological, psychological, and environmental factors increased evidence for the role of viral, bacterial, and parasitic infections in the development of some psychiatric disorders. Studies suggested an association between parasites, especially those with neurological tropism and psychiatric disorders. Toxoplasmosis, human African trypanosomiasis, malaria, Chagas disease, neurocysticercosis, and human toxocariasis are neurotropic parasitosis that has a predilection for central nervous system in different ways, which could be a trigger to develop neuropsychiatric disorders. Neurological and psychiatric sequelae of these infections result mainly from a complex interplay between parasite and host inflammatory and immune response affecting insitu brain neurotransmitters or causing vascular impairment and some work as space occupying lesions. The study reviewed how those neurotropic parasites could be etiological agents for psychiatric and mental disorders.

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Neurochemical measurements in the brains of mice infected withTrypanosoma brucei brucei(TREU 667)

Cited by 14 publications

References 22 publications

Treatment of Trypanosoma evansi-Infected Mice With Eucalyptus camaldulensis Led to a Change in Brain Response and Spleen Immunomodulation

Treatment of Trypanosoma evansi-Infected Mice With Eucalyptus camaldulensis Led to a Change in Brain Response and Spleen Immunomodulation

Neuroimmunology of Common Parasitic Infections in Africa

Neurotropic Parasitic Infections Associated With Psychiatric Disorders: A Review Article

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