1999
DOI: 10.1161/01.str.30.2.460
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Neurochemical Monitoring of Fatal Middle Cerebral Artery Infarction

Abstract: Background-Microdialysis is a method for neurochemical monitoring that has been applied more frequently over the past few years in patients suffering from subarachnoid hemorrhage, acute brain injury, and stroke. It is used to study the course of extracellular molecules of low molecular weight, such as excitatory amino acids or metabolic end products. Case Description-We report the case of a 43-year-old patient suffering from left hemispheric stroke with a space-occupying postischemic edema leading to a conside… Show more

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Cited by 58 publications
(33 citation statements)
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“…To answer this question conclusively, more measurements must be performed and the monitoring perhaps be extended, for example, to microdialysis or CBF measurements, to better assess the "branches" of supply and demand of cerebral oxygen metabolism. 44 We found a pattern change in the PbrO 2 curve to occur between 6 to 18 hours before transtentorial herniation. Obviously, it is too soon and the number of such observations is too small at this moment to draw any conclusions.…”
Section: Discussionmentioning
confidence: 58%
“…To answer this question conclusively, more measurements must be performed and the monitoring perhaps be extended, for example, to microdialysis or CBF measurements, to better assess the "branches" of supply and demand of cerebral oxygen metabolism. 44 We found a pattern change in the PbrO 2 curve to occur between 6 to 18 hours before transtentorial herniation. Obviously, it is too soon and the number of such observations is too small at this moment to draw any conclusions.…”
Section: Discussionmentioning
confidence: 58%
“…Patient 6, whose microdialysis results were published recently, 18 developed secondary neuronal ischemia in the noninfarcted hemisphere as a result of irretractable brain edema and herniation. Dialysate concentrations in the final stage were similar to those obtained from the infarct core.…”
Section: Microdialysis Results Obtained From the Ecf Of Noninfarcted mentioning
confidence: 99%
“…In the search for monitoring tools that permit early identification of such fatal outcome, microdialysis has recently been applied in the care of patients with severe stroke. 24,25 In the present study we investigated a model of transient focal ischemia in cats that has been shown to be prone to secondary deterioration during reperfusion if the duration of the ischemic episode is prolonged to 2 to 4 hours. 21 By choosing a 3-hour ischemic period followed by reperfusion, we expected that a significant number of experiments would lead to transtentorial herniation, and we hypothesized that glutamate elevation is involved in this process.…”
mentioning
confidence: 99%