Neurochemical Substrates and Neuroanatomical Generators of the Event-Related P300

Frodl, Thomas; Bottlender, Ronald; Hegerl, Ulrich

doi:10.1159/000026603

Cited by 179 publications

(116 citation statements)

References 67 publications

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“…Frodl-Bauch et al, 1999). As discussed above, it is well known that the presence of NE increases the effects of these neurotransmitters on neurons in the cortex and elsewhere.…”

Section: Involvement Of Other Neurochemical Systemsmentioning

confidence: 93%

Decision making, the P3, and the locus coeruleus--norepinephrine system.

Nieuwenhuis

Aston‐Jones

Cohen

2005

Psychological Bulletin

1,435

111

1,229

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Psychologists and neuroscientists have had a long-standing interest in the P3, a prominent component of the event-related brain potential. This review aims to integrate knowledge regarding the neural basis of the P3 and to elucidate its functional role in information processing. The authors review evidence suggesting that the P3 reflects phasic activity of the neuromodulatory locus coeruleus-norepinephrine (LC-NE) system. They discuss the P3 literature in the light of empirical findings and a recent theory regarding the information-processing function of the LC-NE phasic response. The theoretical framework emerging from this research synthesis suggests that the P3 reflects the response of the LC-NE system to the outcome of internal decision-making processes and the consequent effects of noradrenergic potentiation of information processing.

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“…Frodl-Bauch et al, 1999). As discussed above, it is well known that the presence of NE increases the effects of these neurotransmitters on neurons in the cortex and elsewhere.…”

Section: Involvement Of Other Neurochemical Systemsmentioning

confidence: 93%

Decision making, the P3, and the locus coeruleus--norepinephrine system.

Nieuwenhuis

Aston‐Jones

Cohen

2005

Psychological Bulletin

1,435

111

1,229

View full text Add to dashboard Cite

show abstract

“…The neurotransmitter systems underlying P300 generation are yet unclear, with various mechanisms implicated (Frodl-Bauch et al, 1999;Hansenne, 2000). However, available data suggest that P3a is related to frontal focal attention and working memory mediated by dopaminergic activity, and that P3b is related to temporal-parietal activity where dense norepinephrine inputs are found (cf.…”

Section: Dual-transmitter Hypothesismentioning

confidence: 99%

Updating P300: An integrative theory of P3a and P3b

Polich

2007

Clinical Neurophysiology

6,465

458

6,265

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The empirical and theoretical development of the P300 event-related brain potential (ERP) is reviewed by considering factors that contribute to its amplitude, latency, and general characteristics. The neuropsychological origins of the P3a and P3b subcomponents are detailed, and how target/ standard discrimination difficulty modulates scalp topography is discussed. The neural loci of P3a and P3b generation are outlined, and a cognitive model is proffered: P3a originates from stimulusdriven frontal attention mechanisms during task processing, whereas P3b originates from temporalparietal activity associated with attention and appears related to subsequent memory processing. Neurotransmitter actions associating P3a to frontal/dopaminergic and P3b to parietal/norepinephrine pathways are highlighted. Neuroinhibition is suggested as an overarching theoretical mechanism for P300, which is elicited when stimulus detection engages memory operations.

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“…Berman et al, 2006), some other studies found no dependency (e.g. Beste et al, 2006;Frodl-Bauch et al, 1999). Given that the P3 is not dependent on the dopamine system there should be no effects of disease or treatment and only a dopamine-independent age-effect should be evident.…”

Section: Introductionmentioning

confidence: 94%

Effects of aging, Parkinson's disease, and dopaminergic medication on response selection and control

Willemssen

Falkenstein

Schwarz

et al. 2011

Neurobiology of Aging

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We examined effects of short-term and long-term dopaminergic medication in Parkinson's disease on conflict monitoring or response selection processes. These processes were examined using event-related potentials (ERPs), while subjects performed a stimulus-response (S-R) compatibility task. An extended sample of young and elderly controls, Parkinson's disease patients with a medication history (PDs) and initially diagnosed, drug-naïve de novo PD patients (de novo PDs) were enrolled. Both PD groups were measured twice (on and off-medication or before and 8 weeks after medication onset).The results show that dopaminergic intervention selectively reduced the pathologically enhanced response selection in compatible S-R relations. This medication effect was already evident after short-term treatment, not differing from long-term treatment and performance in elderly controls. Contrary, age-related attenuations of the N2 in incompatible S-R relations, probably reflecting impaired conflict processing or response control, are unaffected by medication. The results suggest that compatible and incompatible S-R relations demand different neuronal mechanisms within the basal ganglia, as only the former are affected by agonizing the dopaminergic system.

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Neurochemical Substrates and Neuroanatomical Generators of the Event-Related P300

Cited by 179 publications

References 67 publications

Decision making, the P3, and the locus coeruleus--norepinephrine system.

Decision making, the P3, and the locus coeruleus--norepinephrine system.

Updating P300: An integrative theory of P3a and P3b

Effects of aging, Parkinson's disease, and dopaminergic medication on response selection and control

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