Neurocognition and its association with adverse childhood experiences and familial risk of mental illness

Lakkireddy, Sai Priya; Balachander, Srinivas; Dayalamurthy, Pavithra; Bhattacharya, Mahashweta; Joseph, Mino Susan; Kumar, Pramod; Kannampuzha, Anand Jose; Mallappagari, Sreenivasulu; Narayana, Shruthi; Alexander, Alen Chandy; Muthukumaran, M; Sheth, Sweta; Puzhakkal, Joan C.; Ramesh, Vinutha; Thatikonda, Navya Spurthi; Selvaraj, Sowmya; Ithal, Dhruva; Sreeraj, Vanteemar S.; Mahadevan, Jayant; Holla, Bharath; Venkatasubramanian, Ganesan; John, John P.; Murthy, Pratima; Benegal, Vivek; Reddy, Y. C. Janardhan; Jain, Sanjeev; Viswanath, Biju

doi:10.1016/j.pnpbp.2022.110620

Cited by 9 publications

(4 citation statements)

References 70 publications

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“…Exposure to environmental stressors has been linked to both the development of psychiatric disease (Carbone et al, 2019; Kasznia et al, 2021; Lakkireddy et al, 2022) and a variety of other medical disorders, including those of the brain and the immune system (Dube et al, 2009; Eid et al, 2022; Roberts et al, 2022). An emerging concept of how these stressors may be related to health outcomes, whether they be psychiatric or medical, is that ACEs may contribute to worsened allostatic load (Misiak et al, 2022; Piotrowski et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Adverse childhood experiences and the development of Down syndrome regression disorder

Wang

Patel

Sannar

et al. 2023

American J of Med Genetics Pt A

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Down syndrome regression disorder (DSRD) is a clinical symptom cluster of acute or subacute neurocognitive regression in otherwise health persons with Down syndrome. The objective of this study was to evaluate if adverse childhood experiences (ACEs) were more prevalent in children with DSRD than those with DS alone. A survey-based, cohort-based study was performed. Caregivers of individuals with DSRD with onset of symptoms between age 10 and 30 years and DS alone were administered the ACEs questionnaire via an online REDCap survey. A total of 159 responses were collected after excluding incomplete surveys and those not meeting criteria for DSRD. Individuals with DSRD were not more likely to experienceACEs (p = 0.18, 95% confidence interval [CI]: 0.43-1.17). In those with ACEs prior to the onset of symptoms, the median time prior was 7 months (interquartile range: 5-10). Individuals with DSRD were more likely to report three or more ACEs (52, 33%) compared to those with DS alone (39, 22%) (p = 0.02, 95% CI: 1.08-2.87).Exposure to ACEs were not predictive of response to particular therapeutic interventions although those with multiple ACEs 3 months prior to the onset of symptoms was associated with lower response rates to benzodiazepines and immunotherapy

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Section: Discussionmentioning

confidence: 99%

Adverse childhood experiences and the development of Down syndrome regression disorder

Wang

Patel

Sannar

et al. 2023

American J of Med Genetics Pt A

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“…This involves educating children and youth on skills to effectively manage stress and intervening to reduce both immediate and long-term harms. The biological and neuropsychological consequences of ACEs have also been linked to physical abuse in children [44]. According to Teicher and Samson [82], certain forms of childhood physical abuse, including sexual abuse, impact the development of the cerebral cortex, thereby influencing brain function.…”

Section: Acesmentioning

confidence: 99%

Understanding adverse childhood experiences and the call for trauma-informed healthcare system in Turkey: a review

Yildiz,

Aydin,

Aydin

et al. 2024

Health Res Policy Sys

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Over the past four decades, research has underscored the significance of approaching and preventing trauma from a systemic standpoint. Trauma-informed care (TIC) methodologies offer a structure for healthcare practices, striving to convert organizations into trauma-informed systems that employ trauma-specific interventions. This review employs epidemiological and household data from Turkey to underscore the importance of integrating trauma-informed care as a means of prevention and intervention. Through a desk review, the study examines the role of adverse childhood experiences (ACEs), delving into their origin from family dynamics, migration, violence, exposure to violence, juvenile delinquency, and child maltreatment. The research highlights innovative healthcare approaches that leverage data to address complex patient health issues while considering mental health needs. In contemporary times, healthcare organizations acknowledge the value of a data-driven approach to make informed clinical decisions, enhance treatment procedures, and improve overall healthcare outcomes. The reviewed research and empirical data furnish proof of the importance of effective and efficient treatment methods that prioritize trauma prevention and treatment, integrating the role of ACEs. This paper seeks to contribute to discussions on transforming the healthcare system to meet the healthcare needs of Turkish households, all the while taking into account the evolving sociopolitical factors that shape Turkey's population characteristics.

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“…Childhood physical neglect, which ultimately signals childhood deprivation, is also of interest as it has been specifically linked to poorer cognitive performance ( Üçok et al, 2015 ; Li et al, 2017 ; Mørkved et al, 2020 ; Vaskinn et al, 2021 ; Lakkireddy et al, 2022 ), as well as altered WM connectivity, including FA of the UF ( Govindan et al, 2010 ; Hanson et al, 2015 ; Tendolkar et al, 2018 ). The UF is of interest as previous studies have shown specific links between the microstructural organisation of the UF and ER performance ( Coad et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Uncinate fasciculus microstructural organisation and emotion recognition in schizophrenia: controlling for hit rate bias

Stevens,

Ní Mhurchú,

Corley

et al. 2024

Front. Behav. Neurosci.

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IntroductionSchizophrenia (SCZ) is a complex neurodevelopmental disorder characterised by functional and structural brain dysconnectivity and disturbances in perception, cognition, emotion, and social functioning. In the present study, we investigated whether the microstructural organisation of the uncinate fasciculus (UF) was associated with emotion recognition (ER) performance. Additionally, we investigated the usefulness of an unbiased hit rate (UHR) score to control for response biases (i.e., participant guessing) during an emotion recognition task (ERT).MethodsFifty-eight individuals diagnosed with SCZ were included. The CANTAB ERT was used to measure social cognition. Specific ROI manual tract segmentation was completed using ExploreDTI and followed the protocol previously outlined by Coad et al. (2020).ResultsWe found that the microstructural organisation of the UF was significantly correlated with physical neglect and ER outcomes. Furthermore, we found that the UHR score was more sensitive to ERT subscale emotion items than the standard HR score. Finally, given the association between childhood trauma (in particular childhood neglect) and social cognition in SCZ, a mediation analysis found evidence that microstructural alterations of the UF mediated an association between childhood trauma and social cognitive performance.DiscussionThe mediating role of microstructural alterations in the UF on the association between childhood trauma and social cognitive performance suggests that early life adversity impacts both brain development and social cognitive outcomes for people with SCZ. Limitations of the present study include the restricted ability of the tensor model to correctly assess multi-directionality at regions where fibre populations intersect.

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Neurocognition and its association with adverse childhood experiences and familial risk of mental illness

Cited by 9 publications

References 70 publications

Adverse childhood experiences and the development of Down syndrome regression disorder

Adverse childhood experiences and the development of Down syndrome regression disorder

Understanding adverse childhood experiences and the call for trauma-informed healthcare system in Turkey: a review

Uncinate fasciculus microstructural organisation and emotion recognition in schizophrenia: controlling for hit rate bias

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