Neurocognition and long-term prediction of quality of life in outpatients with severe and persistent mental illness

Fujii, Daryl; Wylie, Alyson; Nathan, Jeffrey H.

doi:10.1016/s0920-9964(03)00122-1

Cited by 87 publications

(42 citation statements)

References 33 publications

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“…32) Based on existing studies on the correlation between daily living function and cognitive function, a correlation was found with executive function, 33) attention, 34) and working memory. 35) In addition, another study by the present authors showed a significant correlation between language ability and K-UPSA. 36) K-WAIS, WCST, and SCoRS were conducted as cognitive function tests in this study.…”

Section: Discussionsupporting

confidence: 59%

The Korean version of the University of California San Diego performance-based skills assessment: reliability and validity

Ryu¹

2017

European Neuropsychopharmacology

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Section: Discussionsupporting

confidence: 59%

The Korean version of the University of California San Diego performance-based skills assessment: reliability and validity

Ryu¹

2017

European Neuropsychopharmacology

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“…Cognitive impairment has major functional and symptomatic outcomes and is poorly managed using currently available antipsychotics (Fujii et al 2004;Green et al 2000). Thus, an effective therapy for cognitive deficits would be of great clinical importance.…”

Section: Introductionmentioning

confidence: 99%

d-Serine and a glycine transporter-1 inhibitor enhance social memory in rats

2010

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“…Cognitive deficits in memory, executive function, and working memory are believed to be of major importance to the functional and symptomatic outcome (Fujii and Wylie, 2003;Moritz et al, 2000;Grawe and Levander, 2001;Green et al, 2000) as well as the quality of life (Fujii et al, 2004) of patients with schizophrenia. Being able to address some of these symptoms in a preclinical model and consequently develop drugs that better target these symptoms could lead to better outcome and better quality of life for the patients.…”

Section: Introductionmentioning

confidence: 99%

Cognitive Deficits Caused by Late Gestational Disruption of Neurogenesis in Rats: a Preclinical Model of Schizophrenia

Flagstad

Glenthøj

Didriksen

2004

Neuropsychopharmacol

100

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Late gestational disruption of neurogenesis in rats has been shown to induce behavioral abnormalities thought to mimic aspects of positive and negative symptoms of schizophrenia. Furthermore, it has been shown that the morphological changes produced by the perturbation are relevant to schizophrenia with reduced thickness of the hippocampus, thalamus, and cortical regions. In addition to the positive and negative symptoms, schizophrenia is associated with deficits in a wide variety of cognitive domains. In the present studies, we assessed whether the cognitive deficits are modeled by disruption of neurogenesis late during gestation (gestational day 17) in the rat. In the battery of tests utilized, we describe that rats in which neurogenesis was disrupted have deficits in a reversal-learning paradigm of the Morris water maze and in object recognition, and that they exhibit perseveration in the Porsolt forced swimming test. Additionally, we found deficient associative learning in an acquisition of an active avoidance paradigm and deficits in latent inhibition. No deficits were observed in the reference memory version of the Morris water maze and in a non-match-to position experiment, showing that the deficits are limited to certain aspects of cognition.

show abstract

Neurocognition and long-term prediction of quality of life in outpatients with severe and persistent mental illness

Cited by 87 publications

References 33 publications

The Korean version of the University of California San Diego performance-based skills assessment: reliability and validity

The Korean version of the University of California San Diego performance-based skills assessment: reliability and validity

d-Serine and a glycine transporter-1 inhibitor enhance social memory in rats

Cognitive Deficits Caused by Late Gestational Disruption of Neurogenesis in Rats: a Preclinical Model of Schizophrenia

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