Neurocognitive and psychosocial profiles of children with Turner syndrome

Park, So Yeong; Kim, Su Jin; Lee, Myeongseob; Lee, Hae-In; Kwon, Ah Reum; Suh, Jin‐Suck; Song, Kyungchul; Chae, Hyun Wook; Joo, Bonglim; Kim, Ho-Seong

doi:10.6065/apem.2244222.111

Cited by 3 publications

References 29 publications

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Analysis of the Impact of Digital Therapeutic Interventions on Attention and Working Memory in Children with Attention-Deficit/Hyperactivity Disorder: A Randomized Controlled Trial (Preprint)

Kim,

Lee

2024

Preprint

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BACKGROUND Recent research has explored non-pharmacological digital therapeutic interventions as a means to improve compliance and reduce side effects in medication treatments for children with attention-deficit/hyperactivity disorder(ADHD). OBJECTIVE This study aims to validate the effects of game-based intervention content designed to enhance working memory and concentration. The study monitored quantitative changes using assessment tools to evaluate improvements in these cognitive areas when digital game-based content was employed as adjunct therapy alongside medication for children with ADHD. METHODS A total of 30 children participated were divided into an experimental group receiving digital therapeutic intervention based on game content alongside medication and a control group receiving conventional treatment methods. RESULTS The experimental group exhibited a reduction of 8.13±6.71 points on the K-ARS total score, compared to 7.14±8.73 points in the control group. Inattentiveness and hyperactivity-impulsivity decreased by 23.82% and 17.73%, respectively, more in the experimental group than in the control group. Significant reductions in the K-CBCL total problem behavior score, including internalizing and externalizing behaviors, were consistently observed at 28 d compared to baseline. Results from the FAIR attention-concentration test revealed significant differences between the experimental and control groups in Q-percentile and Q-standard scores (p=0.006 for the experimental group, p=0.007 for the control group) based on repeated measures ANOVA. CONCLUSIONS Digital game-based content demonstrates significant potential as a non-pharmacological therapeutic intervention for ADHD. CLINICALTRIAL Clinical Research Information Service KCT0009326.

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Analysis of the Impact of Digital Therapeutic Interventions on Attention and Working Memory in Children with Attention-Deficit/Hyperactivity Disorder: A Randomized Controlled Trial (Preprint)

Kim,

Lee

2024

Preprint

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Lifelong medical challenges and immunogenetics of Turner syndrome

Cho

2024

Clin Exp Pediatr

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Turner syndrome (TS) is a female phenotypic condition characterized by one or more typical clinical features and the partial or complete absence of a second X chromosome as determined by karyotype analysis. TS, among the most common chromosomal abnormalities, has an estimated prevalence of approximately 1 in 2,500 live-born females, with ethnic and racial differences. TS encompasses a wide array of medical challenges, including cardiovascular, endocrine, autoimmune, and mental health issues, as well as a heightened cancer risk. The somatic stigmata of TS are thought to arise from haploinsufficiency of the X chromosomes. This review explores the lifelong medical challenges and immunogenetics of individuals with TS and aimed to investigate strategies for preventing and managing TS while considering the implications of immunogenetics.

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Cohort profile: Multicenter Networks for Ideal Outcomes of Rare Pediatric Endocrine and Metabolic Diseases in Korea (OUTSPREAD study)

Lee,

Cheon,

Suh

et al. 2024

Ann Pediatr Endocrinol Metab

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Rare endocrine diseases are complex conditions that require lifelong specialized care due to their chronic nature and associated long-term complications. In Korea, a lack of nationwide data on clinical practice and outcomes has limited progress in patient care. Therefore, the Multicenter Networks for Ideal Outcomes of Pediatric Rare Endocrine and Metabolic Disease (OUTSPREAD) study was initiated. This study involves 30 centers across Korea. The study aims to improve the long-term prognosis of Korean patients with rare endocrine diseases by collecting comprehensive clinical data, biospecimens, and patient-reported outcomes to identify complications and unmet needs in patient care. Patients with childhood-onset pituitary, adrenal, or gonadal disorders, such as craniopharyngioma, congenital adrenal hyperplasia (CAH), and Turner syndrome were prioritized. The planned enrollment is 1,300 patients during the first study phase (2022–2024). Clinical, biochemical, and imaging data from diagnosis, treatment, and follow-up during 1980–2023 were retrospectively reviewed. For patients who agreed to participate in the prospective cohort, clinical data and biospecimens will be prospectively collected to discover ideal biomarkers that predict the effectiveness of disease control measures and prognosis. Patient-reported outcomes, including quality of life and depression scales, will be evaluated to assess psychosocial outcomes. Additionally, a substudy on CAH patients will develop a steroid hormone profiling method using liquid chromatography-tandem mass spectrometry to improve diagnosis and monitoring of treatment outcomes. This study will address unmet clinical needs by discovering ideal biomarkers, introducing evidence-based treatment guidelines, and ultimately improving long-term outcomes in the areas of rare endocrine and metabolic diseases.

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Neurocognitive and psychosocial profiles of children with Turner syndrome

Cited by 3 publications

References 29 publications

Analysis of the Impact of Digital Therapeutic Interventions on Attention and Working Memory in Children with Attention-Deficit/Hyperactivity Disorder: A Randomized Controlled Trial (Preprint)

Analysis of the Impact of Digital Therapeutic Interventions on Attention and Working Memory in Children with Attention-Deficit/Hyperactivity Disorder: A Randomized Controlled Trial (Preprint)

Lifelong medical challenges and immunogenetics of Turner syndrome

Cohort profile: Multicenter Networks for Ideal Outcomes of Rare Pediatric Endocrine and Metabolic Diseases in Korea (OUTSPREAD study)

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