Neurocognitive, clinical and functional correlates of subjective quality of life in Asian outpatients with schizophrenia

Woon, Puay San; Chia, Ming Ying; Chan, Wai Yen; Sim, Kang

doi:10.1016/j.pnpbp.2010.01.014

Cited by 53 publications

(58 citation statements)

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“…As it was shown in a meta-analysis of Eack and Newhill [31], general psychopathology was more profoundly correlated with assessments measuring quality of life in patients with schizophrenia than with either positive or negative symptoms, indicating that chronic disability and domains of general psychopathology scale such as anxiety, lack of judgment and sensitivity, abnormal thoughts and conscious social isolation, may be important factors influencing the level of adequate social performance. Better psychosocial functioning is associated with better quality of life [32]. Symptomatology though alters as the disease progresses, resulting in different patterns of association between symptoms and quality of life [33] and it is plausible also for social functioning.…”

Section: Discussionmentioning

confidence: 99%

Correlation between the Personal and Social Performance scale (PSP) and the Positive and Negative Syndrome Scale (PANSS) in a Greek sample of patients with schizophrenia

et al. 2014

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BackgroundPsychosocial dysfunction is one of schizophrenia’s core features, often leading to a deprecation of independent living and significant failure to maintain a competent quality of life. Cognitive and occupational performance as well as psychosocial functioning is moreover recognized as determinants of treatment response. Therefore, the elaboration of measures regarding social performance besides scales that assess psychopathology is essential. The Personal and Social Performance (PSP) scale has been found to be as much valid as reliable for assessing social functioning in the acute and stable stage of schizophrenia. The aim of this study was to estimate the correlation between the PSP and Positive and Negative Syndrome Scale (PANSS) (convergent validity) in patients with schizophrenia during routine clinical practice.MethodsA longitudinal study with a six-month follow-up is presented. Correlation between the PSP scale and the Positive and Negative Syndrome Scale (PANSS) was conducted in a Greek sample of 2010 patients with schizophrenia in outpatient setting in two successive visits. PANSS and PSP scales were used for the assessment of psychopathological symptoms and social and personal functioning.ResultsThe PSP subscales scores were well correlated with each other with Spearman correlation coefficients (r) ranging from 0.56 to 0.76 on both visits in three out of the four main areas, whereas in the category of “disturbing and aggressive behavior” the correlations were lower but still significant. Furthermore, total PSP score showed high association to PANSS total score in the first (r = -0.59) as well as in the second visit (r = -0.50). Regression analysis showed that one point decrease of PANSS’s total score is associated with a 0.42 points increase on the PSP scale. PSP and PANSS scales exhibited high convergent validity.ConclusionsThe PSP could provide additional valuable information in the assessment of schizophrenia related social functioning and treatment response.

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Section: Discussionmentioning

confidence: 99%

Correlation between the Personal and Social Performance scale (PSP) and the Positive and Negative Syndrome Scale (PANSS) in a Greek sample of patients with schizophrenia

et al. 2014

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“…Although negative symptoms have been shown to affect QOL in patients with schizophrenia (Brissos et al, 2011, Woon et al, 2010), only a minority of patients exhibit substantial improvement in QOL, even after achieving symptom remission (Karadayi et al, 2011, Schennach-Wolff et al, 2009). QOL has also been associated with functional outcomes, including employment status, independent living, engagement in daily activities, and maintaining personal relationships (Galuppi et al, 2010, Karadayi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Predicting employment status and subjective quality of life in patients with schizophrenia

Fujino

Sumiyoshi

et al. 2016

Schizophrenia Research: Cognition

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Although impaired social functioning, particularly poor employment status, is a cardinal feature of patients with schizophrenia and leads to decreased quality of life (QOL), few studies have addressed the relationship between these two clinical issues. The aim of this study was to determine whether employment status predicts subjective QOL and to evaluate a model in which functional capacity mediates the relationship between general cognitive performance and employment status. Ninety-three patients with schizophrenia were administered a comprehensive battery of cognitive tests, the UCSD Performance-based Skills Assessment-Brief version (UPSA-B), the Social Functioning Scale (SFS), and the Subjective Quality of Life Scale (SQLS). First, we evaluated a model for predicting the employment/occupation subscale score of the SFS using path analysis, and the model fitted well (χ2 (4) = 3.6, p = 0.46; CFI = 1.0; RMSEA < 0.001, with 90% CIs: 0–0.152). Employment status was predicted by negative symptoms and functional capacity, which was in turn predicted by general cognitive performance. Second, we added subjective QOL to this model. In a final path model, QOL was predicted by negative symptoms and employment status. This model also satisfied good fit criteria (χ2 (7) = 10.3, p = 0.17; CFI = 0.987; RMSEA = 0.072, with 90% CIs: 0–0.159). The UPSA-B and SFS scores were moderately correlated with most measures of cognitive performance. These results support the notion that better employment status enhances subjective QOL in patients with schizophrenia.

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“…Thus, researchers' emphasis on evaluating and enhancing quality of life (QoL) in patients with schizophrenia is gradually increasing. [6][7][8] The World Health Organization Quality of Life Scale Brief Version scale (WHOQOL-BREF) assesses individuals' self-perception of their position in life within the context of the culture and value systems in which they live, and in relation to their goals, expectations and concerns. [9][10][11] Few studies describing the QoL of schizophrenia patients have been published to date, and even fewer have compared the QoL of schizophrenia patients with and without SUD comorbidity.…”

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confidence: 99%

Quality of life among dually diagnosed and non-substance-using male schizophrenia outpatients

2013

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Objective.To assess the quality of life (QoL) in an outpatient setting among male patients dually diagnosed with schizophrenia and substance use disorder (SUD), and non-substance-using male schizophrenia patients. Methods. The study was conducted in an outpatient setting with 52 male schizophrenia patients and 49 male schizophrenia patients with SUD comorbidity, who were admitted to Bakirköy Research and Training Hospital between 1 May 2010 and 30 September 2010. The patients had been in remission for a minimum of 6 months. The subjects were re-evaluated for the persistence of the diagnosis by using the Structural Clinical Interview for DSM-IV Axis I disorders (SCID I) socio-demographic data form, and the World Health Organization Quality of Life Scale Brief Version (WHOQOL-BREF) and positive and negative syndrome scale (PANSS) were administered to detect the factors affecting diagnostic stability and clinical course. Results. Schizophrenia patients with no SUD comorbidity had a significantly earlier age of disease onset than the comorbid group. SUD comorbidity in schizophrenia patients leads to increased rates of unemployment and homicidality. WHOQOL-Bref psychological health scores were significantly lower among patients in the comorbidity group. No statistically significant difference was identified between the groups with regard to the PANSS scores. Conclusions. It is necessary to focus on the treatment challenges for schizophrenia patients with SUD comorbidity, such as the provision of treatment in criminal justice settings, in which a high proportion of such patients are found.

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Neurocognitive, clinical and functional correlates of subjective quality of life in Asian outpatients with schizophrenia

Cited by 53 publications

References 53 publications

Correlation between the Personal and Social Performance scale (PSP) and the Positive and Negative Syndrome Scale (PANSS) in a Greek sample of patients with schizophrenia

Correlation between the Personal and Social Performance scale (PSP) and the Positive and Negative Syndrome Scale (PANSS) in a Greek sample of patients with schizophrenia

Predicting employment status and subjective quality of life in patients with schizophrenia

Quality of life among dually diagnosed and non-substance-using male schizophrenia outpatients

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