Neurocognitive Differential Diagnosis of Dementing Diseases: Alzheimer's Dementia, Vascular Dementia, Frontotemporal Dementia, and Major Depressive Disorder

Braaten, Alyssa; Parsons, Thomas D.; McCue, Robert; Sellers, Alfred H; Burns, William J.

doi:10.1080/00207450600920928

Cited by 83 publications

(64 citation statements)

References 16 publications

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“…These cognitive processes can also be impaired in bvFTD patients. Early bvFTD can therefore be mistaken for depression, especially when neuropsychological profiles are similar between the conditions 16 17. Moreover, brain imaging can fail to provide useful information for the differential diagnosis; MRIs may be normal in the early stages of bvFTD, whereas SPECT and fluorodeoxyglucose positron emission tomography can show frontal hypoperfusion/hypometabolism in MDD 36–38…”

Section: Discussionmentioning

confidence: 99%

Social Cognition and Emotional Assessment differentiates frontotemporal dementia from depression

Bertoux

Delavest

Souza

et al. 2012

J Neurol Neurosurg Psychiatry

161

150

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Background Behavioural variant of frontotemporal dementia (bvFTD) is a neurodegenerative disease that is clinically characterised by progressive behavioural changes and social interpersonal dysfunctions. Its diagnosis remains a clinical challenge, and depression is one of the main causes of misdiagnoses due to the prevalence of apathy in bvFTD. Objective To evaluate the sensitivity and specificity of the Social Cognition and Emotional Assessment (SEA) and the mini-SEA for differentiating bvFTD from major depressive disorder (MDD). Methods Scores for the SEA and mini-SEA for 37 patients with bvFTD (divided into subgroups of 17 with early bvFTD and 20 with moderate bvFTD according to the normal range of the Mattis Dementia Rating Scale), 19 MDD patients and 30 control subjects were compared to define the discrimination power of these tools compared with other standard neuropsychological tests. Results SEA and mini-SEA scores were significantly lower for both the early and moderate bvFTD groups compared with control subjects and the MDD group, and very few scores overlapped between patients in the bvFTD subgroups and patients in the MDD and control subgroups. SEA and mini-SEA scores distinguished early bvFTD from MDD with sensitivity and specificity rates above 94%. Conclusion Unlike standard executive neuropsychological tests, SEA and the mini-SEA can differentiate MDD from bvFTD in the early stages of the disease. The mini-SEA is an easy tool that can be utilised in neurological or psychiatric departments.

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Section: Discussionmentioning

confidence: 99%

Social Cognition and Emotional Assessment differentiates frontotemporal dementia from depression

Bertoux

Delavest

Souza

et al. 2012

J Neurol Neurosurg Psychiatry

161

150

View full text Add to dashboard Cite

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“…A further group that warrants investigation with respect to this phenomenon is a neurological population (i.e., individuals who have sustained damage to their central nervous system via a variety of mechanisms; Sohlberg and Mateer 2001). Research has produced a large body of evidence supporting a link between neurological disorders and cognitive difficulties (e.g., Braaten et al 2006;Mathias and Mansfield 2005;Stephens et al 2004). For the most part these studies compare a neurological group to a "normal" group and attribute differences in cognitive ability to physical causes (i.e., neurophysiological or structural dysfunction).…”

Section: Stereotype Threat In Neurological Populationsmentioning

confidence: 98%

“…This is a relatively novel approach to conceptualizing cognitive deficits following neurological injury. Historically, research has attributed such deficits to organic or biological causes alone (e.g., Braaten et al 2006;Mathias and Mansfield 2005;Stephens et al 2004), and has neglected the role of psychological and situational factors.…”

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confidence: 99%

A Review of the Stereotype Threat Literature and Its Application in a Neurological Population

2008

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Stereotype threat is a situational phenomenon, leading to test performance decrements, in which a member of a stigmatized group feels pressured by the possibility of confirming or being judged by a negative stereotype. This review article highlights the progression of research in the stereotype threat field, and its relevance to neurological populations. Early studies focused on demonstrating this effect in African American, women, and elderly populations. Since this time, research has continued to focus on these populations but has moved to elucidating stereotype threat's mediating psychological factors, studying the impact of individual differences in response to stereotype threat, and attempting to reduce its overall effect. A proposal for further study in neurological populations, under the framework of stereotype threat, comprises the last portion of the paper. It is argued that this social psychological phenomenon may, at least in part, account for poor neuropsychological test performance for neurologically compromised individuals.

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“…[4] . 전두엽 의 등쪽외측 전전두피질 부위의 손상이 나타나면 생 각이 단순해지고 융통성이 없어지고 고집이 세지며 판단력 저하를 포함하는 집행기능의 전반적 저하가 관찰된다고 보고된바도 있다 [5], [6] .…”

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The Evaluation of Cerebral Executive Function Using Functional MRI

Eun¹,

Gook²,

Kim³

2013

Journal of the Korean Society of Radiology

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This study involves an experiment using functional magnetic resonance imaging(fMRI) to delineate brain activation for execution functional performance. Participates to this experiment of the normal adult (man 4, woman 6) of 10 people, is not inserts the metal all closed phobia and 24.5 year-old average ages which the operating surgeon experience which are not they were.The subject for a functional MRI experiment word -color test prosecuting attorney subject rightly at magnetic pole presentation time of 30 first editions and after presenting, uses SPM 99 programs and the image realignment, after executing a standardization (nomalization), a difference which the signal burglar considers the timely order as lattice does, pixel each image will count there probably is, in order to examine rest and active crossroad dividing independence sample t-test (p<.05). Overlapped in this standard anatomic image and got a brain activation image from level of significance 95%.With functional MRI resultant execution function inside being relation, the prefrontal lobe, anterior cingulate gyrus, parietal lobe, orbitofrontal gyrus, temporal lobe, parietal lobe was activated. The execution function promotes a recovery major role from occupational therapy, understanding about the damage mechanism is important. When confirms the brain active area which accomplishes an execution function brain plasticity develops the cognitive therapeutic method which is effective increases usefully very, will be used.

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Neurocognitive Differential Diagnosis of Dementing Diseases: Alzheimer's Dementia, Vascular Dementia, Frontotemporal Dementia, and Major Depressive Disorder

Cited by 83 publications

References 16 publications

Social Cognition and Emotional Assessment differentiates frontotemporal dementia from depression

Social Cognition and Emotional Assessment differentiates frontotemporal dementia from depression

A Review of the Stereotype Threat Literature and Its Application in a Neurological Population

The Evaluation of Cerebral Executive Function Using Functional MRI

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