Neurocognitive function and quality of life in relation to hematocrit levels in chronic hemodialysis patients

Lee, Sun Young; Lee, Heon Jeong; Kim, Yong Ku; Kim, Seung Hyun; Lee, Min Soo; Joe, Sook Haeng; Jung, In Kwa; Suh, Kwang Yoon; Kim, Hyung Kyu

doi:10.1016/s0022-3999(03)00528-2

Cited by 41 publications

(26 citation statements)

References 16 publications

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“…In this investigation, hematocrit was associated with working memory (Letters and numbers), in line with previous findings [42]. Hemoglobin, which has previously been related to neuropsychological performance in ESRD-HD [3, 8], was associated with figural fluency (RFFT total design) in our study.…”

Section: Discussionsupporting

confidence: 92%

Executive function in end-stage renal disease: Acute effects of hemodialysis and associations with clinical factors

et al. 2018

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ObjectiveThere is evidence of cognitive impairment in patients with end-stage renal disease in hemodialysis (ESRD-HD). However, few studies have exhaustively analyzed executive functions (EFs) in this population, especially considering the influence of a wide range of clinical variables. This study analyzes performance in different EF components in ESRD-HD patients compared to a group of healthy controls (HCs), in addition to the acute effects of HD and the associations of cognitive performance with clinical variables.MethodEFs were evaluated pre- and post-HD in 43 ESRD-HD patients and 42 HCs, using a battery of tests designed to assess EF domains. Age, schooling, mood and blood pressure were statistically controlled. Associations between performance and clinical factors were computed by correlations and hierarchical multiple regression analyses.ResultsThe performance of the ESRD-HD patients was significantly lower than that of HCs in all the EF domains except for planning. Group differences were marginally significant for reasoning. HD produced no acute changes in global performance, with improvements see only in inhibition and working memory. EF scores were positively associated with total number of months previously transplanted, body mass index (BMI), dry weight, and levels of hemoglobin, albumin, ferritin, calcium, phosphorus, sodium, urea, and creatinine.ConclusionsGlobal EF functioning was lower in ESRD-HD patients than in HCs. No major acute HD-related EF changes were detected. These findings underline the importance of an adequate nutritional status for maintaining executive functioning in ESRD-HD patients.

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Section: Discussionsupporting

confidence: 92%

Executive function in end-stage renal disease: Acute effects of hemodialysis and associations with clinical factors

et al. 2018

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“…The kidneys are responsible for a variety of functions including: regulating urinary output in relation to dietary salt, water, and mineral intake; the removal of metabolic end-products including urea, uric acid, and creatinine; the regulation of blood pressure through blood volume modulation; the production of erythropoietin (a peptide hormone that is involved in the control of red blood cell production by the bone marrow); the production of the active form of vitamin D; and gluconeogenesis (synthesis of glucose from non-carbohydrate sources such as protein and triglycerides) (Burrows-Hudson 2005; Eaton and Pooler 2004;Lee et al 2004;Lieberthal and Nigam 2000;Pliskin et al 2001). Failure of the kidneys to remove metabolic end-products from the blood results in waste buildup, leading eventually to uremia.…”

Section: Basic Renal Physiology and Measures Of Renal Functionmentioning

confidence: 99%

“…However, similar findings have been documented by other investigators using cross-sectional designs. Lee et al (2004) examined whether increasing hematocrit via administration of rHuEPO improves cognitive functioning. The sample comprised patients receiving hemodialysis divided into a high-hematocrit (>27.2%) group and a lowhematocrit group (< 27.2%).…”

Section: Studies Examining Cognitive Functioning In Hemodialysis In Rmentioning

confidence: 99%

Adult Chronic Kidney Disease: Neurocognition in Chronic Renal Failure

2009

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In recent years there has been a keen interest in the neurocognitive sequelae of renal failure and subsequent end-stage renal disease given its increasing prevalence and incidence. This review article summarizes the relevant information on cognitive functioning in chronic kidney disease in adults before the initiation of dialysis, after the initiation of dialysis, and after renal transplantation. In general, compared to pre-dialysis, there is an improvement in cognitive function after the institution of dialysis and further improvement after renal transplantation. Throughout the paper an attempt is made to highlight the importance of considering disease related variables in the neuropsychological assessment of individuals with chronic kidney disease. The paper concludes with a discussion of future avenues of research.

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“…Cognitive impairment is associated with adverse outcomes and a decreased quality of life [5,6]. Cerebrovascular disease, anemia, uremic toxins, and secondary hyperparathyroidism (SHPT) have been reported to be major causes of cognitive impairment in CKD patients [7][8][9][10]. SHPT is characterized by high parathyroid hormone (PTH) levels, normal or low calcium levels and low vitamin D levels.…”

Section: Introductionmentioning

confidence: 99%

Structural network topology correlates to cognitive impairment and iPTH level in End-stage renal disease patients with peritoneal dialysis

Wang

Zou

et al. 2019

Preprint

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KEYWORDS 2 end-stage renal disease, secondary hyperparathyroidism, structural connectivity, topological organization, network Abstract Objective: The burden of cognitive impairment in patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis has received more attention lately. It is associated with hospitalization, mortality and reduced quality of life. We aimed to assess the topological alterations of the brain white matter structural network in ESRD and the correlation between network metrics with Montreal Cognitive Assessment scores and clinical data. Methods: The study included 25 ESRD patients with secondary hyperparathyroidism (SHPT group), 25 patients without SHPT (Non-SHPT group) and 25 healthy controls (HC group) of comparable age and sex. Cognitive function was assessed using the Montreal Cognitive Assessment. The WM structural network was constructed by diffusion tensorimaging and a deterministic tractography method, and then we used graph theoretical approaches to investigate alterations in the global and regional properties of the WM networks in these participants.Results: ESRD patients showed cognitive impairment compared to HC, and the SHPT patients had lower cognitive scores than the Non-SHPT patients. The global topological organization and local efficiency of the WM network was significantly disrupted in the SHPT but not in the Non-SHPT patients compared with the HC group. Moreover, lower regional efficiency was found in the ESRD patients, mainly distributed in the frontal and parietal cortices. In addition, an association was found between iPTH, shortest path length and cognitive impairment, and the iPTH level was negatively correlated with small-worldness by two indexes, the normalized clustering coefficient and the normalized shortest path length. Conclusion: The present study indicated that the brain structural connectome in ESRD patients with high iPTH levels was disrupted in association with cognitive impairment and it is a potential connectome-based biomarker for early detection.

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Neurocognitive function and quality of life in relation to hematocrit levels in chronic hemodialysis patients

Cited by 41 publications

References 16 publications

Executive function in end-stage renal disease: Acute effects of hemodialysis and associations with clinical factors

Executive function in end-stage renal disease: Acute effects of hemodialysis and associations with clinical factors

Adult Chronic Kidney Disease: Neurocognition in Chronic Renal Failure

Structural network topology correlates to cognitive impairment and iPTH level in End-stage renal disease patients with peritoneal dialysis

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