Neurocognitive functioning as an intermediary variable between psychopathology and insight in schizophrenia

Hwang, Suntae; Ahn, Yong Min; Kim, Yong Sik

doi:10.1016/j.psychres.2015.11.004

Cited by 8 publications

(3 citation statements)

References 41 publications

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“…Poor insight has been correlated with difficulties in set shifting in acute and non-acute phases of schizophrenia 121,122 , the ability to change behavior following feedback on an executive function task 123 , complex motor sequencing 124 , and the ability to recall autobiographical details about negative events 125 .…”

Section: Neurocognition As a Root Of Poor Insightmentioning

confidence: 99%

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

et al. 2018

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Poor insight in schizophrenia is prevalent across cultures and phases of illness. In this review, we examine the recent research on the relationship of insight with behavior, mood and perceived quality of life, on its complex roots, and on the effects of existing and emerging treatments. This research indicates that poor insight predicts poorer treatment adherence and therapeutic alliance, higher symptom severity and more impaired community function, while good insight predicts a higher frequency of depression and demoralization, especially when coupled with stigma and social disadvantage. This research also suggests that poor insight may arise in response to biological, experiential, neuropsychological, social-cognitive, metacognitive and socio-political factors. Studies of the effects of existing and developing treatments indicate that they may influence insight. In the context of earlier research and historical models, these findings support an integrative model of poor insight. This model suggests that insight requires the integration of information about changes in internal states, external circumstances, others' perspectives and life trajectory as well as the multifaceted consequences and causes of each of those changes. One implication is that treatments should, beyond providing education, seek to assist persons with schizophrenia to integrate the broad range of complex and potentially deeply painful experiences which are associated with mental illness into their own personally meaningful, coherent and adaptive picture.

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Section: Neurocognition As a Root Of Poor Insightmentioning

confidence: 99%

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

et al. 2018

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“…38 These findings in patients with chronic schizophrenia are consistent with other studies that have found links between cognition and poorer insight in EPP. 58 Despite the strength of these initial findings in EPP subjects, there are a number of limitations for the current study. Patients were all receiving antipsychotic medication, which could influence the variables of interest.…”

Section: Discussionmentioning

confidence: 85%

“…38 These findings in patients with chronic schizophrenia are consistent with other studies that have found links between cognition and poorer insight in EPP. 58…”

Section: Discussionmentioning

confidence: 99%

Relationship of Metacognition and Insight to Neural Synchronization and Cognitive Function in Early Phase Psychosis

et al. 2019

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Metacognition is the process of thinking about one’s own mental states. It involves a range of faculties that allow an individual to integrate information and form understanding of self and others, and use this understanding to respond to life challenges. Clinical insight is the awareness of one’s mental illness, its consequences, and the need for treatment. Persons with psychotic disorders show impaired metacognition and insight, but the neurobiological bases for these impairments are not well characterized. We hypothesized that metacognition and insight may depend on capacity of neural circuits to synchronize at gamma frequencies, as well as the integrity of underlying cognitive processes. In order to test these hypotheses, 17 adults with early phase psychosis were evaluated. Metacognition was assessed with the Metacognition Assessment Scale–Abbreviated, and insight was assessed with the Scale of Unawareness of Illness–Abbreviated. The auditory steady state response (ASSR) to gamma range stimulation (40 Hz) was used as an index of neural synchronization. Cognitive function was assessed using the Brief Assessment of Cognition in Schizophrenia. Increases in ASSR power were associated with poorer metacognition and insight. Higher cognitive performance was associated with higher levels of metacognitive function and insight. These findings suggest that altered neural synchronization and constituent cognitive processes affect both metacognition and insight in early phase psychosis and may offer targets for both pharmacological and psychotherapeutic interventions.

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Relating constructs of attention and working memory to social withdrawal in Alzheimer’s disease and schizophrenia: issues regarding paradigm selection

Gilmour

Porcelli

Bertaina-Anglade³

et al. 2019

Neuroscience & Biobehavioral Reviews

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Neurocognitive functioning as an intermediary variable between psychopathology and insight in schizophrenia

Cited by 8 publications

References 41 publications

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

Relationship of Metacognition and Insight to Neural Synchronization and Cognitive Function in Early Phase Psychosis

Relating constructs of attention and working memory to social withdrawal in Alzheimer’s disease and schizophrenia: issues regarding paradigm selection

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