Neurocognitive Functioning of Children and Adolescents with Mild-to-Moderate Chronic Kidney Disease

Hooper, Stephen R.; Gerson, Arlene C.; Butler, Robert W.; Gipson, Debbie S.; Mendley, Susan R.; Lande, Marc B.; Shinnar, Shlomo; Wentz, Alicia; Matheson, Matthew B.; Cox, Christopher; Furth, Susan L.; Warady, Bradley A.

doi:10.2215/cjn.09751110

Cited by 166 publications

(162 citation statements)

References 25 publications

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“…Beyond the well-known complications of CKD such as anemia, poor growth, and renal osteodystrophy, many children with CKD have impaired neurocognitive function and reduced quality 109,110 Early intervention in these areas could improve school performance and selfesteem.…”

Section: Intervention and Educationmentioning

confidence: 99%

Short-Term Gestation, Long-Term Risk: Prematurity and Chronic Kidney Disease

2013

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Thanks to remarkable advances in neonatal intensive care, infants who once had little chance for survival can now enter adulthood. Yet the consequences of premature birth or low birth weight (LBW) on nephrogenesis, final nephron number, and long-term kidney function are unclear. This review focuses on the theory, experimental evidence, and observational data that suggest an increased risk of chronic kidney disease (CKD) for infants born prematurely. Many premature and LBW infants begin life with an incomplete complement of immature nephrons. They are then exposed to a variety of external stressors that can hinder ongoing kidney development or cause additional nephron loss such as hemodynamic alterations, nephrotoxic medications, infections, and suboptimal nutrition. Acute kidney injury, in particular, may be a significant risk factor for the development of CKD. According to Brenner' s hypothesis, patients with decreased nephron number develop hyperfiltration that results in sodium retention, hypertension, nephron loss, and CKD due to secondary focal segmental glomerulosclerosis. Because the risk of CKD in premature and LBW infants has not been accurately determined, there are no evidence-based recommendations for screening or management. Yet with the first generation of infants from the surfactant era only now reaching adulthood, it is possible that there is already an unrecognized epidemic of CKD. We suggest individualized, risk-based assessments of premature and LBW infants due to the increased risk of CKD and call for additional research into the long-term risk for CKD these infants face.

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Section: Intervention and Educationmentioning

confidence: 99%

Short-Term Gestation, Long-Term Risk: Prematurity and Chronic Kidney Disease

2013

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“…The amount of available data on CKD and ESRD in children has recently increased (3). For instance, the Chronic Kidney Disease in Children Study, a large North American pediatric observational cohort multicenter study, has compiled noteworthy information regarding fundamental issues in this population, such as hypertension, anemia, dyslipidemia, neurocognitive development, and somatic growth (4)(5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

A Predictive Model of Progression of CKD to ESRD in a Predialysis Pediatric Interdisciplinary Program

Cerqueira¹,

Soares²,

Silva

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives The incidence of ESRD in children has increased over the last two decades. Nevertheless, there are still limited data on risk factors related to the emergence of ESRD among patients with CKD. The aim of this study was to develop a model of prediction of ESRD in children and adolescents with CKD (stages 2-4) enrolled in a predialysis interdisciplinary management program.Design, setting, participants, & measurements In this retrospective cohort study, 147 patients with CKD admitted from 1990 to 2008 were systematically followed up at a tertiary pediatric nephrology unit for a median of about 4.5 years. The primary outcome was the progression to CKD stage 5. A predictive model was developed using Cox proportional hazards model and evaluated by c statistics.Results The median renal survival was estimated at 98.7 months (95% confidence interval [95% CI], 68.7 to 129.6 months). The probability of reaching CKD stage 5 was estimated as 52% in 10 years. The most accurate model included eGFR, proteinuria at admission, and primary renal disease. Risk score ranged from 0 to 13 points (median, 4 points). The accuracy of the score applied to the sample was high, with c statistics of 0.865 (95% CI, 0.80 to 0.93) and 0.837 (95% CI, 0.76 to 0.91) at follow-up of 2 and 5 years, respectively. By survival analysis, it was estimated that at 10 years after admission, the probability of renal survival was about 63% for patients in the lowrisk group and 43% for the medium-risk group; all patients assigned to the high-risk group had CKD stage 5 (P,0.001). ConclusionThe predictive model of progression of CKD might contribute to early identification of a subgroup of patients at high risk for accelerated renal failure.

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“…While the problem of anxiety disorders is quite well--discussed in the accessible to us literature [22][23][24][25], anyway the studies devoted to an impact of the chronic diseases on anxiety level are rather rare [26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Peculiarities of situational and personal anxiety degree in the schoolchildren with ENT chronic diseases

Mardiyan

Mkrtchyan

Shukuryan

et al. 2017

Health Qual Life Outcomes

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Background: A number of the QL researches in case of different pathologies are being increased during the last decade. The existing traditional research methods provide mostly arbitrary data on the disease and its treatment, which are not sufficient for the schoolchildren overall psychological and social adaptation and wellness evaluation. Methods: The research object became schoolchildren of 3 randomly selected schools in Yerevan. 443 monitoring units formed the selection population. The degree of situational and personal anxiety was evaluated with the help of Spielberger's and Gerbachevski's tests. Results: According to our research data the anxiety degree was 29,2 ± 2,3 points among the girls and 12,5 ± 1,6 points among the boys, respectively. The individual anxiety level was especially high: it made up 44,5 ± 0,8 points, and that of the situational anxiety made up 37,2 ± 0,5 points (p < 0,05). According to Gerbachovski's test in the group of schoolchildren with ENT pathology those with a high level of demands made up 53,5 ± 3,2%, with a medium level of demands -32,4 ± 3,0% and with a low level of demands −14,1 ± 2,2%. A number of the practically healthy schoolchildren with a low level of demands made up 50,3%, and with a high level -30,7%. Conclusion: According to the investigation data those children who suffer from the ENT chronic diseases usually avoided communication, were sluggish and shy. According to the results of the research, the socio-psychological and adaptation abilities of children with the ENT chronic diseases were lower than those of the practically healthy (without ENT pathologies) coevals. This fact urges to improve the prophylactic measures provision in the mentioned pathologies aspect.

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Neurocognitive Functioning of Children and Adolescents with Mild-to-Moderate Chronic Kidney Disease

Cited by 166 publications

References 25 publications

Short-Term Gestation, Long-Term Risk: Prematurity and Chronic Kidney Disease

Short-Term Gestation, Long-Term Risk: Prematurity and Chronic Kidney Disease

A Predictive Model of Progression of CKD to ESRD in a Predialysis Pediatric Interdisciplinary Program

Peculiarities of situational and personal anxiety degree in the schoolchildren with ENT chronic diseases

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