Neurocognitive outcome of school-aged children with congenital heart disease who underwent cardiopulmonary bypass surgery: a systematic review protocol

Abstract

Background Over the past decades, survival rates of children born with congenital heart disease (CHD) have increased dramatically. Progress in prenatal diagnosis, less-invasive catheter techniques and perioperative intensive care as well as surgical techniques have led to an increased focus on extracardiac comorbidities, including potential neurodevelopmental sequelae associated with CHD. A growing body of literature reports impairments in early and school-age developmental outcome; however, there is a substantial variability in the spectrum of examined CHD types, assessment ages and applied test batteries. Furthermore, little information is available on executive function impairments in this population. Therefore, the aim of this systematic review is to determine the impact of CHD on intellectual outcome and executive functioning at school age and to determine risk factors for impaired outcomes by means of a systematic search. Methods A systematic review of literature that reports neurodevelopmental outcome in children with CHD undergoing cardiopulmonary bypass surgery. Intelligence quotient or executive function scores will be considered primary outcomes. Databases such as Cochrane, EMBASE, MEDLINE and PsycINFO will be searched. Discussion The results of this systematic review will summarize the current evidence on intellectual and executive function outcome after cardiopulmonary bypass surgery in school-age children with CHD. This review will thus be the basis for better patient and parental counselling and the establishment of tailored follow-up programmes and interventional trials. Systematic review registration In accordance with the guidelines, our systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on January 9, 2019 (CRD42018086568). PROSPERO CRD42019118736.

Prevalence of Neonatal Sepsis in Ethiopia: A Systematic Review and Meta-Analysis

“…Neonatal sepsis can be classified as early onset sepsis acquired from birth to 7 days and late onset sepsis acquired after delivery in the normal newborn nursery, the neonatal intensive care unit, or the community (8 to 30 days). Thus, meta-analysis was performed for two or more studies reporting the same outcomes [10].…”

Time to sputum culture conversion and its associated factors among multidrug-resistant tuberculosis patients in Eastern Africa: A systematic review and meta-analysis

“…Two independent authors (DBK and MA) screened titles and abstracts of a random sample of 665 eligible studies generated by our search. Agreement on inclusion for a full-text screening of >80% between the two independent authors was considered as good (Feldmann et al, 2019), and the remaining references were divided among the authors for further screening and discussion with a third author (MAA) to find consensus as required.…”

Desenvolvimento neurológico após correção de cardiopatia congênita no período neonatal

“…Durante a cirurgia, um tempo mais longo de circulação extracorpórea (CEC), baixos graus de hipotermia, tempo de parada circulatória, elevadas quantidades de benzodiazepínicos e narcóticos, podem conferir mais riscos para o cérebro em desenvolvimento (Barkhuizen et al, 2020;Feldmann et al, 2019;Gano, McQuillen, 2021;Kordopati-Zilou et al, 2022).…”

“…Contudo, nas últimas décadas, os avanços na CEC em conjunto com o uso de drogas neuroprotetoras, como nitroprussiato de sódio e o alopurinol demonstraram reduzir as taxas de mortalidade de pacientes com CC. Essas medidas levaram a estatística crescente de crianças atingindo a adolescência e a idade adulta (Stegeman et al, 2018;Feldmann et al, 2019).…”