Neurocognitive performance, psychopathology and social functioning in individuals at high risk for schizophrenia or psychotic bipolar disorder

Gkintoni, Evgenia; Pallis, Eleftherios G.; Bitsios, Panos; Giakoumaki, Stella G.

doi:10.1016/j.jad.2016.10.032

Cited by 42 publications

(43 citation statements)

References 116 publications

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“…Moreover, even patients with normal and not deteriorated intellectual levels showed neuropsychological deficits (Ruiz et al ., ; Vaskinn et al ., ; Weickert et al ., ). This fact supports the hypothesis that cognitive impairment is an endophenotypic marker of schizophrenia (Gkintoni, Pallis, Bitsios, & Giakoumaki, ). Subsequent studies described heterogeneous results.…”

Section: Introductionsupporting

confidence: 87%

Intellectual and cognitive profiles in patients affected by schizophrenia

Bechi

Spangaro

Agostoni

et al. 2018

Journal of Neuropsychology

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Intellectual abilities display high heterogeneity in patients with schizophrenia that might depend on the interaction among neurodevelopmental processes, environmental factors and neurocognitive decline. This study aimed to disentangle the interplay between intellectual level, cognitive status and each cognitive domain, with a focus on speed-related abilities, also including pre-morbid factors. In details, by means of cluster analysis, we identified both in global sample of 452 patients affected by schizophrenia and in a subsample with high pre-morbid functioning, different profiles based on current intellectual level and global cognitive status, analysing the distribution of deficits in each cognitive domains between groups. Then, through regression models, we analysed the contribution of speed-related domains and global cognitive profile to each other cognitive function. Considering the whole sample, results highlight three groups (high, medium and low cognitive level), while among patients with high pre-morbid level, the heterogeneity was best captured by two groups (high and medium level). Still, within each group, a small to high percentage of patients achieved normal score in neurocognitive abilities depending on the cluster they belong to. Speed of processing and psychomotor coordination resulted impaired in all clusters, even in patients with high pre-morbid functioning. The regression analyses revealed significant effects of both cognitive profile and speed-dependent domains on the other cognitive abilities. This study confirms, in a large sample, previous data about the heterogeneity of intellectual and neurocognitive functioning in schizophrenia and highlights the main role of speed-dependent neurocognitive functioning, also as an important target of rehabilitation.

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Section: Introductionsupporting

confidence: 87%

Intellectual and cognitive profiles in patients affected by schizophrenia

Bechi

Spangaro

Agostoni

et al. 2018

Journal of Neuropsychology

View full text Add to dashboard Cite

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“…Three other studies were excluded as they were based on overlapping samples with other studies included. A total of 20 studies (21 reports) were included in the meta-analysis (Table 1) [19,20,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47].…”

Section: Resultsmentioning

confidence: 99%

A comparative meta-analysis of neurocognition in first-degree relatives of patients with schizophrenia and bipolar disorder

Bora

2017

Eur. psychiatr.

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“…These did not overlap with SNPs included in the schizophrenia score at this threshold, thus indicating a potential genetic overlap between block design impairment and bipolar disorder risk. Cognition has also been put forward as a possible endophenotype for bipolar disorder (Gkintoni, Pallis, Bitsios, & Giakoumaki, ; Miskowiak et al, ; Trotta, Murray, & MacCabe, ), although the evidence is much more limited than for schizophrenia and further research is required.…”

Section: Discussionmentioning

confidence: 99%

A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains

Ranlund

Calafato

Thygesen

et al. 2017

American J of Med Genetics Pt B

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This large multi‐center study investigates the relationships between genetic risk for schizophrenia and bipolar disorder, and multi‐modal endophenotypes for psychosis. The sample included 4,242 individuals; 1,087 patients with psychosis, 822 unaffected first‐degree relatives of patients, and 2,333 controls. Endophenotypes included the P300 event‐related potential (N = 515), lateral ventricular volume (N = 798), and the cognitive measures block design (N = 3,089), digit span (N = 1,437), and the Ray Auditory Verbal Learning Task (N = 2,406). Data were collected across 11 sites in Europe and Australia; all genotyping and genetic analyses were done at the same laboratory in the United Kingdom. We calculated polygenic risk scores for schizophrenia and bipolar disorder separately, and used linear regression to test whether polygenic scores influenced the endophenotypes. Results showed that higher polygenic scores for schizophrenia were associated with poorer performance on the block design task and explained 0.2% (p = 0.009) of the variance. Associations in the same direction were found for bipolar disorder scores, but this was not statistically significant at the 1% level (p = 0.02). The schizophrenia score explained 0.4% of variance in lateral ventricular volumes, the largest across all phenotypes examined, although this was not significant (p = 0.063). None of the remaining associations reached significance after correction for multiple testing (with alpha at 1%). These results indicate that common genetic variants associated with schizophrenia predict performance in spatial visualization, providing additional evidence that this measure is an endophenotype for the disorder with shared genetic risk variants. The use of endophenotypes such as this will help to characterize the effects of common genetic variation in psychosis.

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Neurocognitive performance, psychopathology and social functioning in individuals at high risk for schizophrenia or psychotic bipolar disorder

Cited by 42 publications

References 116 publications

Intellectual and cognitive profiles in patients affected by schizophrenia

Intellectual and cognitive profiles in patients affected by schizophrenia

A comparative meta-analysis of neurocognition in first-degree relatives of patients with schizophrenia and bipolar disorder

A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains

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