Neurocomputational models of the remote effects of focal brain damage

Reggia, James A.

doi:10.1016/j.medengphy.2004.06.010

Cited by 22 publications

(17 citation statements)

References 62 publications

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“…However, focal cerebral ischemia induced an imbalance of blood flow in both hemispheres through secondary remote effects 40 or diaschisis. 41 To prevent neural loss and avoid the development of a necrosis, neurons induce preconditioning and decrease genes involved in metabolic pathways.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin II Type-2 Receptor Stimulation Prevents Neural Damage by Transcriptional Activation of Methyl Methanesulfonate Sensitive 2

Mogi

Iwanami

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Angiotensin II Type-2 Receptor Stimulation Prevents Neural Damage by Transcriptional Activation of Methyl Methanesulfonate Sensitive 2

Mogi

Iwanami

et al. 2006

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“…Even simulations in computer models have shown that neural networks lateralize and cluster processing elements in response to learning, suggesting that this kind of organization is computationally and energetically efficient 25 …”

Section: The Evolutionary and Developmental Context Of The Neural Netmentioning

confidence: 99%

Functional Imaging of Stroke Recovery: An Ecological Review from a Neural Network Perspective with an Emphasis on Motor Systems

Ween

2008

Journal of Neuroimaging

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Functional imaging is beginning to outline the brain's functional architecture and mechanisms of recovery from injury. I will review primarily the motor-function literature from normal populations, learning trials, stroke recovery, and rehabilitation with a neural network approach that may prove fruitful in further advancing our understanding of brain plasticity in response to focal lesions. A key consideration in this review will be how the development of distributed motor networks might constrain recovery as a function of the altered connectivity between damaged and nondamaged areas. It will be argued that this connectivity is central to both recovery from injury and response to treatment.

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“…One immediate effect of stroke is diaschisis, activity abnormalities in intact brain areas secondary to loss of input signals that originally came from the damaged area (Reggia, 2004). Diaschisis has been primarily explored as occurring when a large stroke on one side disrupts activity on the other side, with loss of signals across the corpus callosum.…”

Section: Functional Effects Of Strokementioning

confidence: 99%