Neurocristopathies

Watt, Kristin E. Noack; Trainor, Paul A.

doi:10.1016/b978-0-12-401730-6.00018-1

Cited by 21 publications

(8 citation statements)

References 237 publications

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“…NC cells are a migratory population unique to vertebrates which gives rise to a variety of derivatives throughout the body, including neurons and glia of the peripheral nervous system, melanocytes, and much of the craniofacial skeleton and connective tissue (Le Douarin and Kalcheim, 1999). A large number of human health conditions are caused by defects in NC development, collectively known as “neurocristopathies” (Bolande, 1997), and include craniofacial malformations such as cleft lip and cleft palate, rare diseases such as Waardenburg syndrome, and aggressive cancers including melanoma and neuroblastoma (Etchevers et al, 2006; Farlie et al, 2004; Watt and Trainor, 2014). Therefore, the development and subsequent terminal differentiation of NC has been the subject of intense focus.…”

Section: Introductionmentioning

confidence: 99%

Early specification and development of rabbit neural crest cells

Betters

Charney

Garcı́a-Castro

2018

Developmental Biology

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The phenomenal migratory and differentiation capacity of neural crest cells has been well established across model organisms. While the earliest stages of neural crest development have been investigated in non-mammalian model systems such as Xenopus and Aves, the early specification of this cell population has not been evaluated in mammalian embryos, of which the murine model is the most prevalent. Towards a more comprehensive understanding of mammalian neural crest formation and human comparative studies, we have used the rabbit as a mammalian system for the study of early neural crest specification and development. We examine the expression profile of well-characterized neural crest markers in rabbit embryos across developmental time from early gastrula to later neurula stages, and provide a comparison to markers of migratory neural crest in the chick. Importantly, we apply explant specification assays to address the pivotal question of mammalian neural crest ontogeny, and provide the first evidence that a specified population of neural crest cells exists in the rabbit gastrula prior to the overt expression of neural crest markers. Finally, we demonstrate that FGF signaling is necessary for early rabbit neural crest formation, as SU5402 treatment strongly represses neural crest marker expression in explant assays. This study pioneers the rabbit as a model for neural crest development, and provides the first demonstration of mammalian neural crest specification and the requirement of FGF signaling in this process.

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Section: Introductionmentioning

confidence: 99%

Early specification and development of rabbit neural crest cells

Betters

Charney

Garcı́a-Castro

2018

Developmental Biology

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“…Owing to the broad contribution of neural crest cells to derivatives throughout the body, a large number of human health conditions are associated with improper neural crest development and differentiation. Collectively known as “neurocristopathies” (Bolande, , ; Vega‐Lopez, Cerrizuela, Tribulo, & Aybar, ), these include craniofacial malformations, rare diseases such as Waardenburg syndrome, and aggressive cancers such as neuroblastoma and melanoma (Etchevers, Amiel, & Lyonnet, ; Farlie, McKeown, & Newgreen, ; Watt & Trainor, ). Of particular clinical relevance, craniofacial malformations account for over one‐third of all congenital birth defects (Twigg & Wilkie, ).…”

Section: Introductionmentioning

confidence: 99%

Specification and formation of the neural crest: Perspectives on lineage segregation

Prasad

Charney

Garcı́a-Castro

2019

Genesis

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Summary The neural crest is a fascinating embryonic population unique to vertebrates that is endowed with remarkable differentiation capacity. Thought to originate from ectodermal tissue, neural crest cells generate neurons and glia of the peripheral nervous system, and melanocytes throughout the body. However, the neural crest also generates many ectomesenchymal derivatives in the cranial region, including cell types considered to be of mesodermal origin such as cartilage, bone, and adipose tissue. These ectomesenchymal derivatives play a critical role in the formation of the vertebrate head, and are thought to be a key attribute at the center of vertebrate evolution and diversity. Further, aberrant neural crest cell development and differentiation is the root cause of many human pathologies, including cancers, rare syndromes, and birth malformations. In this review, we discuss the current findings of neural crest cell ontogeny, and consider tissue, cell, and molecular contributions toward neural crest formation. We further provide current perspectives into the molecular network involved during the segregation of the neural crest lineage.

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“…Identification of a common NC contribution to disparate tissues provided an explanation of clinical associations of symptoms that had not been previously understood. Such diseases that could be ultimately traced back to a problem in NC development were called 'neurocristopathies' (Bolande, 1974(Bolande, , 1997; reviewed among many others by Etchevers et al, 2006;Watt and Trainor, 2014;Vega-Lopez et al, 2018) (see timeline in Fig. 3).…”

Section: Relevance Of Neural Crest Experimental Embryology To Human Hmentioning

confidence: 99%

The diverse neural crest: from embryology to human pathology

2019

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We review here some of the historical highlights in exploratory studies of the vertebrate embryonic structure known as the neural crest. The study of the molecular properties of the cells that it produces, their migratory capacities and plasticity, and the still-growing list of tissues that depend on their presence for form and function, continue to enrich our understanding of congenital malformations, paediatric cancers and evolutionary biology. Developmental biology has been key to our understanding of the neural crest, starting with the early days of experimental embryology and through to today, when increasingly powerful technologies contribute to further insight into this fascinating vertebrate cell population.

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Neurocristopathies

Cited by 21 publications

References 237 publications

Early specification and development of rabbit neural crest cells

Early specification and development of rabbit neural crest cells

Specification and formation of the neural crest: Perspectives on lineage segregation

The diverse neural crest: from embryology to human pathology

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