Neurocysticercosis and Oncogenesis

Brutto, Oscar H. Del; Dolezal, Milana; Castillo, Pablo R.; Garcı́a, Héctor H.

doi:10.1016/s0188-4409(00)00049-7

Cited by 47 publications

(25 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, a link between NCC and oncogenesis has been postulated. 17 In this regard, one of our patients, during the evolution of cysticercal disease, developed a cerebellar medulloblastoma (unpublished data).…”

Section: Resultsmentioning

confidence: 76%

Spinal cord cysticercosis: neurosurgical aspects

Colli¹,

Valênça²,

Carlotti³

et al. 2002

FOC

View full text Add to dashboard Cite

Object The authors report their experience in the treatment of 12 symptomatic patients with intradural spinal neurocysticercosis. Methods The mean age of the 12 patients was 33 years. There were eight female and four male patients. Cysticercosis was present in association with hydrocephalus in nine cases. In nine of 12 patients the spinal lesion was confined to the thoracic or lumbar spinal cord, and in three the cysticerci occupied the cervical region. In all patients with hydrocephalus nerve root symptoms developed seven to 48 months later (mean 27.6 ± 15.5 months). In one patient hydrocephalus was absent, but he presented with cysticercal meningitis 24 months before spinal cord compression developed. Presenting symptoms suggesting spinal cysticercosis included muscular weakness (67%), pain (67%), and sphincter disturbance (25%). Neurological examination demonstrated a motor deficit in nine patients, sensory deficit in four, and radicular pain in three. The prognosis was worse in patients with moderate-to-severe arachnoiditis and spinal cord compression compared with those with isolated nerve roots involvement in whom outcome was favorable. Ten patients underwent laminectomy, after which neurological status improved in 44%, remained unchanged in 33%, or worsened in 22.2%. Conclusions The authors discuss their findings in these cases. Additionally they briefly review the literature, patho-physiology, and therapeutic and/or surgical strategies involved in this disease.

show abstract

Section: Resultsmentioning

confidence: 76%

Spinal cord cysticercosis: neurosurgical aspects

Colli¹,

Valênça²,

Carlotti³

et al. 2002

FOC

View full text Add to dashboard Cite

show abstract

“…In addition, it has been suggested the occurrence of cellular immune dysfunction in patients with neurocysticercosis, resulting from increased subpopulations of CD8 T-lymphocytes, impaired proliferation of lymphocytes, and abnormal concentration of cytokines. It has been hypothesized that this depressed cellular immunity may be responsible for the reported association of neurocysticercosis with conditions resulting from immunodeficiency states, and with the development of gliomas [16]; in such cases, it has been hypothesized that the intense glial proliferation around the parasites, along with the suppression of the cellular immune responses may cause inhibition of the immunological surveillance against cancer, leading to malignant transformation of astrocytes [17]. …”

Section: Etiopathogenesismentioning

confidence: 99%

Neurocysticercosis: A Review

Brutto

2012

The Scientific World Journal

172

171

View full text Add to dashboard Cite

Neuroysticercosis is the most common helminthic infection of the nervous system, and a leading cause of acquired epilepsy worldwide. The disease occurs when humans become intermediate hosts of Taenia solium by ingesting its eggs from contaminated food or, most often, directly from a taenia carrier by the fecal-to-oral route. Cysticerci may be located in brain parenchyma, subarachnoid space, ventricular system, or spinal cord, causing pathological changes that are responsible for the pleomorphism of neurocysticercosis. Seizures are the most common clinical manifestation, but many patients present with focal deficits, intracranial hypertension, or cognitive decline. Accurate diagnosis of neurocysticercosis is possible after interpretation of clinical data together with findings of neuroimaging studies and results of immunological tests. The introduction of cysticidal drugs have changed the prognosis of most patients with neurocysticercosis. These drugs have shown to reduce the burden of infection in the brain and to improve the clinical course of the disease in most patients. Further efforts should be directed to eradicate the disease through the implementation of control programs against all the interrelated steps in the life cycle of T. solium, including human carriers of the adult tapeworm, infected pigs, and eggs in the environment.

show abstract

“…These pathogenetic mechanisms may independently exert a carcinogenic effect or may interact with each other, resulting in additive cancer risk [Del Brutto et al, 2000].…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity of vesicular fluid and saline extract of Taenia solium metacestodes in somatic cells of Drosophila melanogaster

Silva

Costa-Cruz

Spanó

et al. 2006

Environ and Mol Mutagen

View full text Add to dashboard Cite

Neurocysticercosis, the most common parasitic disease of the central nervous system, is caused by cysticerci of the helminth Taenia solium, which is prevalent in developing countries and is reemerging in affluent societies. This helminth is associated with brain tumors and hematological malignancies in humans. In the present study, we analyzed the genotoxicity of vesicular fluid (VF) and a saline extract (SE) of T. solium metacestodes in the Drosophila melanogaster wing somatic mutation and recombination test (SMART). Third-instar larvae derived from standard and high bioactivation crosses were treated for approximately 48 hr with 12.5, 25.0, and 50.0 microg/ml of VF and SE of T. solium metacestodes. Negative (phosphate buffered saline) and positive (10 mM urethane) controls were also included. The results showed that the two test compounds were genotoxic in both crosses of Drosophila. Nevertheless, further research is needed to determine the genotoxic potential of specific compounds present in VF and SE and their role in the development of cancer.

show abstract

Neurocysticercosis and Oncogenesis

Cited by 47 publications

References 39 publications

Spinal cord cysticercosis: neurosurgical aspects

Spinal cord cysticercosis: neurosurgical aspects

Neurocysticercosis: A Review

Genotoxicity of vesicular fluid and saline extract of Taenia solium metacestodes in somatic cells of Drosophila melanogaster

Contact Info

Product

Resources

About