Neurocytoma Presenting with Intraparenchymal Cerebral Hemorrhage

Abstract

Neurocytomas are uncommon intracranial neoplasms that have only recently been characterized pathologically. Neurocytomas are histologically benign neoplasms that are often quite large when diagnosed, and previous reports have commonly described presentation with mass effect or cerebrospinal fluid outflow obstruction. We describe the first case of neurocytoma presenting with intraparenchymal cerebral hemorrhage.

Gamma Knife Radiosurgery for Central Neurocytomas

“…Similar cases of change in the biological behavior of the tumor from benign to malignant variants with aggressive growth have been reported. 4,6,14,15,17,21,27,29,32,36) Therefore, central neurocytomas may not always remain benign in the long term.…”

“…2,3,[5][6][7][8][9][10][11][12][13][14]16,19,31,32,36) They are usually located in the lateral ventricles with or without extension to the third ventricles in young adults. 2,3,8,10,19) Standard initial treatment for central neurocytomas is a total resection whenever possible.…”

“…9,15,20,29) Local recurrence is not rare after incomplete surgical resection, leading to tumor progression, intracerebral hemorrhage, or craniospinal dissemination, with or without any indication of malignant change. 3,4,6,7,11,12,14,15,17,21,24,27,29,30,32) Central neurocytoma tends to be radiosensitive, so postoperative conventional radiotherapy and radiosurgery have been used to treat residual tumors after incomplete surgical resection or recurrence. 15,20,[23][24][25][26]31,32,34) Gamma knife radiosurgery (GKS) is effective against postoperative residual tumors or local recurrences of central neurocytomas.…”

“…3,4,6,7,11,12,14,15,17,21,24,27,29,30,32) Central neurocytoma tends to be radiosensitive, so postoperative conventional radiotherapy and radiosurgery have been used to treat residual tumors after incomplete surgical resection or recurrence. 15,20,[23][24][25][26]31,32,34) Gamma knife radiosurgery (GKS) is effective against postoperative residual tumors or local recurrences of central neurocytomas. [1][2][3]6,9,13,14,25,27,28,35,37) However, central neurocytoma is rare and often resected completely, with conservative treatment for the relatively small residual or recurrent tumors.…”

Central Neurocytoma Presenting With Massive Hemorrhage Leading to Coma -Case Report-

“…11,13,24,30) The incidence of intracranial hemor- [1][2][3]6,7,9,10,12,15,[19][20][21]25,26,29) excluding three cases of hemorrhagic extraventricular neurocytoma. 17,23,28) Since the first case of central neurocytoma in 1982, 8) more than 500 cases of central neurocytoma have been reported in total, 18,25) so these 16 hemorrhagic cases account for approximately 3% of all reported central neurocytomas. Accordingly, hemorrhage from central neurocytoma may not be so rare as previously considered, although the reported number is still too small to be conclusive.…”