Neurodegenerative diseases: From available treatments to prospective herbal therapy

Solanki, Isha; Parihar, Priyanka; Parihar, Mordhwaj S.

doi:10.1016/j.neuint.2015.11.001

Cited by 102 publications

(64 citation statements)

References 93 publications

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“…Current pharmacological treatments for PD are symptomatic and associated with various side effects. Accumulating evidence has revealed the anti‐ageing and neuroprotective effects of natural products from traditional medicines, which may provide alternative therapies for neurodegenerative disorders including PD (Shen et al , ; Kim et al , ; Li et al , ; Islam et al , ; Solanki et al , ; Sun et al , ). Because targeting ALP has recently proposed as a promising strategy for PD and other neurodegenerative diseases (Menzies et al , ), the protective effects of genetically or pharmacologically activated ALP have been tested in experimental models of PD in recent years.…”

Section: Resultsmentioning

confidence: 99%

Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review

et al. 2017

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The autophagy-lysosome pathway (ALP) is a primary means by which damaged organelles and long-lived proteins are removed from cells and their components recycled. Impairment of the ALP has been found to be linked to the pathogenesis of Parkinson's disease (PD), a chronic neurodegenerative disorder characterized by the accumulation of protein aggregates and loss of dopaminergic neurons in the midbrain. In recent years, some active compounds derived from plants have been found to regulate the ALP and to exert neuroprotective effects in experimental models of PD, raising the possibility that autophagy enhancement may be an effective therapeutic strategy in PD treatment. In this review, we summarize recent findings of natural products that enhance ALP and thereby protect against PD. Research articles were retrieved from PubMed using relevant keywords in combination. Papers related to the topic were identified, and then the reliability of the experiments was assessed in terms of methodology. The results suggest that targeting the ALP with natural products is a promising strategy for PD treatment. However, risk of bias exists in some studies due to the defective methodology. Rigorous experimental design following the guidelines of autophagy assays, molecular target identification and in vivo efficacy evaluation is critical for the development of ALP enhancers for PD treatment in future studies.

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Section: Resultsmentioning

confidence: 99%

Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review

et al. 2017

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“…These compounds may serve as active ingredients for novel therapies in the treatment of neurodegenerative diseases including Alzheimer's and Parkinson's disease [6]. Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, ALS, and Huntington's disease, are characterized by memory loss, irregular movement or behaviour and emotional difficulties due to a loss of neurons in the central nervous system [1,16]. Alzheimer's disease is a neurodegenerative disease in which beta-amyloid accumulates causing loss of memory which may result in dementia [11].…”

Section: Introductionmentioning

confidence: 99%

“…Parkinson's disease is a result of loss of dopaminergic receptor function, thereby reducing dopamine and causing symptoms, such as resting tremors and rigid limbs [17]. These neurodegenerative disorders may be caused by a combination of environmental, genetic, and age-related factors and can be treated using conventional drug therapies which are currently only moderately effective and often focus on symptom control not reversal or prevention of progression [16,8]. Oxidative stress is often a factor in neurodegenerative disease development and progression and can be remedied using antioxidant drugs, or natural compounds i.e., phenolic compounds including flavonoids and diarylheptanoids [3,1,18].…”

Section: Introductionmentioning

confidence: 99%

Flavonoids and Diarylheptanoids: Neuroprotective Activities of Phytochemicals

Parasram

2017

IJPPE

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Abstract. Plants are often used as sources of lead compounds with phenolic compounds frequently attributed to physiological effects. Flavonoids and diarylheptanoids are important groups of phenolic compounds that impart antioxidant, antitumorgenic, antinflammatory, and neuroprotective effects. These neuroprotective effects can be harnessed to develop treatments for neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Recent discoveries have characterized new neuroprotective compounds and/or sources and tested treatments on cell lines and model animals to improve treatments for future persons with neurodegenerative disorders.

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“…Intracellular neurofibrillary tangles (NFTs), extracellular senile plaque (SP), and abnormal cholinergic transmitter metabolism in the central nervous system (CNS) are pathological features observed in AD patients upon autopsy [1]. Hyperphosphorylation of tau is believed to account for most NFTs.…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer’s Disease Model Rats Induced by Aβ_1–42

Cao

Jia

Wei

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Objective. Huannao Yicong Decoction (HYD, 还脑益聪方) has been shown to improve the learning and memory capabilities of Alzheimer's disease (AD) subjects. However, the underlying mechanism remains to be determined. Methods. Sixty Sprague-Dawley rats were divided equally and randomly into five different groups including control, positive control, and HYD granules of low dose, medium dose, and high dose by daily gavage. The sham-treated rats were also given the same volume of sterile water by gavage. Twelve SD rats were treated with the same amount of physiological saline. Twelve weeks later, learning and memory capabilities, Aβ content of the right brain and the expression of glycogen synthase kinase-3β (GSK-3β), total tau protein kinase (TTBK1), and cyclin-dependent kinase-5 (CDK-5) were tested. Results. Our results showed that high dose HYD treatment significantly improved the learning and memory capability of the AD rats and decreased the expression of TTBK1, GSK-3β, and CDK-5 in the hippocampal CA1 region. Conclusions. HYD treatment for 12 weeks significantly improved spatial learning and memory and effectively inhibited Aβ deposition, likely via reducing tau protein kinase expression and thus tau hyperphosphorylation and inflammatory injury. Taken together, these results suggest that HYD could be an effective treatment for AD.

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Neurodegenerative diseases: From available treatments to prospective herbal therapy

Cited by 102 publications

References 93 publications

Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review

Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review

Flavonoids and Diarylheptanoids: Neuroprotective Activities of Phytochemicals

Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer’s Disease Model Rats Induced by Aβ_1–42

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Neurodegenerative diseases: From available treatments to prospective herbal therapy

Cited by 102 publications

References 93 publications

Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review

Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review

Flavonoids and Diarylheptanoids: Neuroprotective Activities of Phytochemicals

Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer’s Disease Model Rats Induced by Aβ1–42

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Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer’s Disease Model Rats Induced by Aβ_1–42