Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities

Ayeni, Emmanuel Ayodeji; Aldossary, Ahmad M.; Ayejoto, Daniel A.; Gbadegesin, Lanre Anthony; Alshehri, Abdullah A.; Alfassam, Haya A.; Afewerky, Henok Kessete; Almughem, Fahad A.; Saidu, Muhammad Bello; Tawfik, Essam A.

doi:10.3390/ijerph191912495

Cited by 35 publications

(14 citation statements)

References 232 publications

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“…Even though they frequently differ, several susceptibility genes have been discovered for both illnesses. Ion channels, neurotransmitter receptors, and synaptic protein genes have all been linked to epilepsy [29]. Contrarily, genetic variations affecting insulin secretion and resistance impact diabetes [29,30].…”

Section: Genetic Factorsmentioning

confidence: 99%

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Seizing the Connection: Exploring the Interplay Between Epilepsy and Glycemic Control in Diabetes Management

Nadeem,

Memon,

Qureshi

et al. 2023

Cureus

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Epilepsy, a neurological disorder characterized by recurrent seizures, and diabetes, a metabolic disorder characterized by impaired regulation of glucose levels, are two distinct conditions that may appear unrelated at first glance. Nevertheless, recent scholarly investigations have revealed these entities' intricate and everevolving interplay. This review initially delves into the intricate interplay between epilepsy and its potential ramifications on glycemic control. Seizures, particularly those accompanied by convulsive manifestations, have the potential to induce acute perturbations in blood glucose levels via diverse mechanisms, encompassing the liberation of stress hormones, the emergence of insulin resistance, and the dysregulation of the autonomic nervous system. Comprehending these intricate mechanisms is paramount in customizing productive strategies for managing diabetes in individuals with epilepsy. On the contrary, it is worth noting that diabetes can substantially impact the trajectory and control of epilepsy. The correlation between hyperglycemia and an elevated susceptibility to seizures, as well as the potential for exacerbating the intensity of epilepsy, has been established. This narrative review offers a concise exposition of the intricate interplay between epilepsy and glycemic control within diabetes management. The objective of exploring reciprocal influences, underlying mechanisms, and common risk factors is to augment the clinical comprehension of this intricate interconnection. In essence, this acquired knowledge possesses the potential to serve as a guiding compass for healthcare professionals, enabling them to craft bespoke therapeutic approaches that enhance the holistic welfare of individuals grappling with the coexistence of epilepsy and diabetes.

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Section: Genetic Factorsmentioning

confidence: 99%

“…Ion channels, neurotransmitter receptors, and synaptic protein genes have all been linked to epilepsy [29]. Contrarily, genetic variations affecting insulin secretion and resistance impact diabetes [29,30]. Some genes, such as KCNJ11 and ABCC8, have been linked to both diseases, albeit [30].…”

Section: Genetic Factorsmentioning

confidence: 99%

Seizing the Connection: Exploring the Interplay Between Epilepsy and Glycemic Control in Diabetes Management

Nadeem,

Memon,

Qureshi

et al. 2023

Cureus

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“…NDDs and neurological diseases are classified based on various parameters such as anatomical distribution, main clinical features, and important molecular abnormalities. Multiple sclerosis (MS), Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD) are common NDDs/neurological diseases that result in the progressive deterioration of neurons [ 3 , 4 ]. The prevalence of neurodegenerative disorders is rapidly increasing alongside the increase in the aging global population.…”

Section: Introductionmentioning

confidence: 99%

The Exosome-Mediated PI3K/Akt/mTOR Signaling Pathway in Neurological Diseases

Iranpanah

Moradi

Saso³

et al. 2023

Pharmaceutics

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As major public health concerns associated with a rapidly growing aging population, neurodegenerative diseases (NDDs) and neurological diseases are important causes of disability and mortality. Neurological diseases affect millions of people worldwide. Recent studies have indicated that apoptosis, inflammation, and oxidative stress are the main players of NDDs and have critical roles in neurodegenerative processes. During the aforementioned inflammatory/apoptotic/oxidative stress procedures, the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway plays a crucial role. Considering the functional and structural aspects of the blood–brain barrier, drug delivery to the central nervous system is relatively challenging. Exosomes are nanoscale membrane-bound carriers that can be secreted by cells and carry several cargoes, including proteins, nucleic acids, lipids, and metabolites. Exosomes significantly take part in the intercellular communications due to their specific features including low immunogenicity, flexibility, and great tissue/cell penetration capabilities. Due to their ability to cross the blood–brain barrier, these nano-sized structures have been introduced as proper vehicles for central nervous system drug delivery by multiple studies. In the present systematic review, we highlight the potential therapeutic effects of exosomes in the context of NDDs and neurological diseases by targeting the PI3K/Akt/mTOR signaling pathway.

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“…Neurodegenerative disorders are identified as neuronal disorders that influence both the central and peripheral nervous systems causing progressive loss of neurons from the different regions of the brain and/or spinal cord. Neurodegenerative disorders are affecting millions of people worldwide and are one of the significant causes of mortality and disability globally (Ayeni et al, 2022). Multiple surveys worldwide reported that the annual incidence ratios of neurodegenerative disorders are estimated to be 10-15 per 100,000, 2% of which are people over the age of 65 years.…”

Section: Introductionmentioning

confidence: 99%

“…Prominent neurodegenerative disorders including AD, PD, HD, ALS, MS, TBI, and cerebral ischemia have greater threats to public health and heavier economic burden (Ayeni et al, 2022). The average life expectancy has increased dramatically due to medical advancements.…”

Section: Introductionmentioning

confidence: 99%

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

Al‐Shami

Essawy

Elkader

2023

Phytotherapy Research

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Neurodegenerative disorders are heterogeneous, debilitating, and incurable groups of brain disorders that have common features including progressive degeneration of the structure and function of the nervous system. Phytoestogenic‐isoflavones have been identified as active compounds that can modulate different molecular signaling pathways related to the nervous system. The main aim is to shed the light on the molecular mechanisms followed by phytoestrogen‐isoflavones profound in the Trifolium pratense and discuss the latest pharmacological findings in the treatment of neurodegenerative disorders. Data were collected using different databases. The search terms used included “Phytoestrogens,” “Isoflavones,” “neurodegenerative disorders,” “Neuronal plasticity,” etc., and combinations of these keywords. As a result, this review article mainly demonstrates the potential neuroprotective properties of phystoestrogen‐isoflavones present in the Trifolium pratense (Red clover), particularly in neurodegenerative disorders. Phytochemical studies have shown that Trifolium pratense mainly includes more than 30 isoflavone compounds. Among them, phytoestrogen‐isoflavones, such as biochanin A, daidzein, formononetin, genistein (Gen), etc.,are characterized by potent neuroprotective properties against different neurodegenerative disorders. There are preclinical and clinical scientific evidence on their mechanisms of action involve molecular interaction with estrogenic receptors, anti‐inflammatory, anti‐oxidative, antiapoptotic, autophagic inducing, and so on. phytoestrogen‐isoflavones are the major bioactive components in the Trifolium pratense that exhibit therapeutic efficacy in the case of neurodegenerative disorders. This review provides detailed molecular mechanisms targeted by phytoestrogen‐isoflavones and experimental key findings for the clinical use of prescriptions containing Trifolium pratense‐derived isoflavones for the treatment of neurodegenerative disorders.

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Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities

Cited by 35 publications

References 232 publications

Seizing the Connection: Exploring the Interplay Between Epilepsy and Glycemic Control in Diabetes Management

Seizing the Connection: Exploring the Interplay Between Epilepsy and Glycemic Control in Diabetes Management

The Exosome-Mediated PI3K/Akt/mTOR Signaling Pathway in Neurological Diseases

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

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