Abstract:The review considers the main molecular physiological causes of neurodegenerative disorders. The genetic factors involved in Parkinson's and Alzheimer's diseases are conventionally divided into pharmacodynamic and pharmacokinetic. The former are analyzed at the levels of dopamine (DA) neurons and polymorphism of the D 1 , D 2 , and D 3 DA receptors. The role of polymorphisms of some proteins such as parkin (PARK1-PARK10) and α -synuclein in generation of Lewy bodies is described. The pharmacokinetic factors pl… Show more
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