Neurodermitis

Abstract

Atopic dermatitis is one of the most common skin diseases and is associated with an impaired quality of life due to tormenting itching and stigmatization. The disease almost always manifests in early childhood and exhibits specific features in this phase, with involvement of the extensor sides of the extremities. During the further course of disease, the typical flexor involvement becomes quite clear and a considerable proportion of patients develop the associated atopic respiratory diseases. Therapeutic and prophylactic measures focus on the prevention of trigger factors, basic skin care, and application of lipid-replenishing creams, as well as patient and parent education. In the case of exacerbation, anti-inflammatory drugs are treatment of choice.

Characterization of Classical Flexural and Nummular Forms of Atopic Dermatitis in Childhood with Regard to Anamnestic, Clinical and Epidermal Barrier Aspects

“…The classical variant of AD (CAD) manifests in the form of an eczema in the flexures. In contrast, the nummular variant (NAD) manifests with coin-shaped lesions, primarily on the legs, and less commonly on the trunk and arms (7)(8)(9). Clinical experience shows that NAD is more often refractory to therapy than is CAD (8).…”

“…In contrast, the nummular variant (NAD) manifests with coin-shaped lesions, primarily on the legs, and less commonly on the trunk and arms (7)(8)(9). Clinical experience shows that NAD is more often refractory to therapy than is CAD (8). Thus, there may also be differences between both variants, for example, in medical history (including initial manifestation, temporal changes, comorbidities and family history), in other clinical characteristics (including atopic stigmata) or in the structure and function of the epidermal barrier.…”