Neurodevelopment of children exposed in utero to lamotrigine, sodium valproate and carbamazepine

Abstract

In utero exposure to LTG did not have the detrimental effect on child development that was seen with NaV and with CBZ.

Carbamazepine as a Possible Anthropogenic Marker in Water: Occurrences, Toxicological Effects, Regulations and Removal by Wastewater Treatment Technologies

“…These are two forms of a life-threatening skin condition with an overall mortality rate of 30%, in which cell death causes the epidermis to separate from the dermis [113]. Recent studies have also revealed that intrauterine exposure of CBZ is associated with spina bifida [114] and neuro developmental problems [115] of human embryo when gravidas were exposed to CBZ monotherapy. Atkinson et al [116] also reported higher fetal losses and congenital malformation rates among women who were prescribed carbamazepine during pregnancy.…”

IQ at 6 years after in utero exposure to antiepileptic drugs

“…7-15 Despite limitations, 16 there is growing evidence that exposure to sodium valproate (VPA) in utero is associated with significantly poorer functioning. [10][11][12]15,17 Prospective studies consistently document that VPA is associated with an increase in risk of cognitive impairment in young children, 10,12,15 but any longer-term effects are unlikely to be comprehensively documented until the children studied are of school age, when cognitive development is more stable.…”

“…1 Determining the association between exposure to AEDs and child cognitive functioning represents a challenge, and a number of different methodologies have been utilized in its investigation including case studies, [2][3][4] retrospective studies, 5,6 and prospective studies. [7][8][9][10][11][12][13][14][15] Despite limitations, 16 there is growing evidence that exposure to sodium valproate (VPA) in utero is associated with significantly poorer functioning. [10][11][12]15,17 Prospective studies consistently document that VPA is associated with an increase in risk of cognitive impairment in young children, 10,12,15 but any longer-term effects are unlikely to be comprehensively documented until the children studied are of school age, when cognitive development is more stable.…”

Managing epilepsy in pregnancy

“…Children exposed to carbamazepine in utero also demonstrated some degree of neurodevelopmental delay; ten out of 49 (20.4%); two significant, eight mild. However, those children exposed to lamotrigine in utero appeared to produce similar results to the control subjects (one out of 35 [2.9%]) [54].…”