Neurodevelopment outcome of newborns with cerebral subependymal pseudocysts at 18 and 46 months: a prospective study

Abstract

Neurodevelopment of newborns with SEPC was normal when no underlying disease was present. This study suggests that if NE is normal at birth and congenital CMV infection can be excluded, then no further investigations are needed. Moreover, it is crucial to differentiate SEPC from c-PVL which carries a poor prognosis.

Prenatal features of isolated subependymal pseudocysts associated with adverse pregnancy outcome

“…In our series, all children with normal prenatal US and MRI findings (except for SEPC) had a favorable clinical outcome, as described in previous studies. Mild neurological deficiencies have been described during the first year but a normal neurodevelopmental status was observed after a 3‐year follow‐up. The risk for neurodevelopmental disability was significantly higher when SEPC were associated with fetal infection, intrauterine growth restriction, malformations and chromosomal aberrations or persistence of the cysts during follow‐up.…”

Prenatal Evaluation, Imaging Features, and Neurodevelopmental Outcome of Prenatally Diagnosed Periventricular Pseudocysts

“…4,[11][12][13][14][15][16] Makhoul et al, 11 in a meta-analysis of the literature on infants, concluded that in the absence of additional factors, including IUGR, fetal infections, malformations, and chromosomal aberrations or persistence of PVPC, a favorable outcome is expected. Cevey-Macherel et al 16 described the biggest cohort, which included 74 neonates. They concluded that isolated PVPC are associated with normal neurodevelopment and suggested that a neurologic examination at birth is a good outcome predictor.…”

“…To establish whether isolated PVPC have a better prognosis as suggested by several studies, 4,[12][13][14][15][16] cases were divided into 2 groups (Fig 2):…”

“…They have suggested that isolated PVPC have a good prognosis. 4,[12][13][14][15][16] The growing use of prenatal imaging such as fetal ultrasound (US) and MR imaging led to an increase in prenatal detection of PVPC. However, the significance of these findings is not well-established.…”

Infecção congênita por CMV: potenciais marcadores preditivos de alterações tardias em crianças assintomáticas

“…Dentre as sintomáticas, os achados mais comuns forma as calcificações Macherel et al, seguiram prospectivamente crianças com este achado e mostraram que o desenvolvimento neuropsicomotor foi normal em crianças que não tinham nenhuma patologia associada. Os mesmos autores mostraram que 8/43 (19%) das crianças eram infectadas congenitamente por CMV, sendo 4 assintomáticas ao nascer(63).Com relação à surdez neurossensorial, já é bem documentado que a infecção congênita por CMV contribui significativamente para a perda auditiva pré-lingual em crianças(27,28).A surdez neurossensorial identificada ao nascer, foi observada em 10,6 % das crianças infectadas, taxa similar ao observado em estudo anterior realizado porYamamoto et al, 2012, Diferentemente do estudo de Amir et al, que apresentaram evidências de que as alterações em neuroimagens, como a presença de vasculopatia lenticuloestriada, são potenciais preditores de surdez neurossensorial em crianças com infecção congênita, neste estudo, as crianças infectadas com presença de alterações em NTF não apresentaram maior risco de ocorrência de surdez neurossensorial . Os resultados deste estudo e o realizado por Rivera et al, 2002, sugerem que os mecanismos patogênicos que contribuem para o desenvolvimento da surdez neurossensorial em crianças com infecção congênita por CMV, sintomáticas e assintomáticas, podem ser diferentes daqueles responsáveis pelo déficit cognitivo e motor.…”