Neurodevelopmental assessment after congenital cytomegalovirus infection.

Abstract

The neurodevelopmental state of 41 children with congenital cytomegalovirus infection and their controls was assessed at 2 years using the Griffiths scale. The scores achieved by children with congenital cytomegalovirus but with no associated neurological abnormality (asymptomatic) were similar to those of the control children, whereas the mean score of the five children with congenital infection and neurological impairment (symptomatic) was significantly lower. This study, which has the statistical power to detect differences in developmental quotient as small as five points, gave no evidence that at 2 years cytomegalovirus infection was associated with mental retardation in the absence of other neurological impairment. Thus 90% of children with congenital cytomegalovirus infection at 2 years are neurologically and developmentally normal.

Hearing and neurodevelopmental outcomes for children with asymptomatic congenital cytomegalovirus infection: A systematic review

“…Five studies assessed neurodevelopmental outcomes for AcCMV compared with ScCMV. Children with ScCMV performed consistently worse on neurodevelopmental assessments than those with AcCMV, with all 5 studies demonstrating poorer neurodevelopmental outcomes for ScCMV cohorts compared with AcCMV cohorts . The cumulative incidence for neurodevelopmental impairment in the ScCMV cohorts for these studies ranged from 30.7% to 66.7%.…”

“…Eleven studies compared neurodevelopmental outcomes in AcCMV to controls. Eight of these reported no difference in performance on neurodevelopmental assessments between AcCMV cases and controls, whilst Lanari et al reported neurodevelopmental impairment in only 1/35 (2.9%) of AcCMV cases compared with 0/16 controls over an average 18‐month follow‐up period. The remaining 2 studies reported worse performance on neurodevelopmental assessments for AcCMV cases compared with controls .…”

Prevalence of a positive TORCH and parvovirus B19 screening in pregnancies complicated by polyhydramnios

“…The incidence of primary infection during pregnancy is estimated being of 1–2% . If the infection is transmitted to the fetus, almost 90% of infected babies are asymptomatic, and in case of maternal secondary infection, symptoms are mostly transient and less worrisome …”

Intelligence and Academic Achievement With Asymptomatic Congenital Cytomegalovirus Infection

“…This confirms findings of smaller studies which found no significant difference in intelligence measures through early or late childhood. 6, 7, 9–11, 13, 14, 32 Our study included infants identified through hospital-based newborn screening followed through adolescence, and provides new information on intellectual functioning, language and academic achievement of children with asymptomatic congenital CMV infection with and without SNHL compared to a group of uninfected children.…”

“…5 Most other studies followed a small number of children with asymptomatic congenital CMV infection (median: 32, range: 15–60) 6–11, 16 through ≤5 years of age. 7, 9, 10, 12, 13, 16 In this study, we examined intelligence, language, and academic achievement among children with asymptomatic congenital CMV infection identified through hospital-based newborn screening and uninfected children followed through age 18 years.…”