Neurodevelopmental damage after prenatal infection: Role of oxidative stress in the fetal brain

Lanté, Fabien; Meunier, Johann; Guiramand, Janique; Maurice, Tangui; Cavalier, Mélanie; Ferreira, Marie-Céleste de Jesus; Aimar, Rose; Cohen-Solal, Catherine; Vignes, Michel; Barbanel, Gérard

doi:10.1016/j.freeradbiomed.2007.01.027

Cited by 122 publications

(115 citation statements)

References 74 publications

Supporting

Mentioning

106

Contrasting

Order By: Relevance

“…Specifically, male Sprague Dawley (P28) offspring exposed to maternal LPS during late gestation (GD19) showed spatial learning and memory deficits in the MWM compared to male controls. There were no spatial learning and memory deficits observed in female offspring exposed to maternal LPS compared to female controls (Lante et al, 2007). In the same study, Lante et al (2007) found that prenatal LPS induced inhibition of NMDA receptor-dependent processes in male rat offspring.…”

Section: Learning and Memorymentioning

confidence: 87%

“…There were no spatial learning and memory deficits observed in female offspring exposed to maternal LPS compared to female controls (Lante et al, 2007). In the same study, Lante et al (2007) found that prenatal LPS induced inhibition of NMDA receptor-dependent processes in male rat offspring. They found a significant increase in AMPA/NMDA ratio suggesting that NMDA had less of a contribution to basal synaptic transmission, demonstrating that impairment in LTP seen in prenatal LPSexposed male offspring was the result of direct alteration of synaptic NMDA receptors, consistent with findings described by others (Escobar et al, 2011;Oh-Nishi et al, 2010).…”

Section: Learning and Memorymentioning

confidence: 87%

“…In some cases (Bilbo et al, 2005;Shi et al, 2003) a true infection is induced, whereas in other cases, inflammation is induced using LPS (e.g., Boisse et al, 2004;Lante et al, 2007), poly(I:C) (Ellis et al, 2006;Meyer et al, 2006a) or a cytokine (e.g., Samuelsson et al, 2006;Smith et al, 2007). These varied approaches may be important as Schwarz and Bilbo (2011) recently showed that LPS and neonatal (n) E. coli infection in 4 day old rat pups elicit markedly different inflammatory profiles in the brain (similar findings were seen with maternal IL-6 and poly(I:C), in Hsiao and Patterson, 2011).…”

Section: Methodological Considerationsmentioning

confidence: 99%

“…Although limited, the literature that exists on the effect of prenatal immune activation on synaptic plasticity, learning and memory with sex as a factor reveal that prenatal immune activation can impair learning and memory (e.g., Howland et al, 2012;Lante et al, 2007;Zhang et al, 2011), but not all show sex-specific deficits (e.g., Samuelsson et al, 2006;Wang et al, 2010).…”

Section: Learning and Memorymentioning

confidence: 99%

“…For example, Lante et al (2007) found LPSinduced inhibition of LTP, and spatial learning and memory deficits in prenatally immune challenged male offspring. Specifically, male Sprague Dawley (P28) offspring exposed to maternal LPS during late gestation (GD19) showed spatial learning and memory deficits in the MWM compared to male controls.…”

Section: Learning and Memorymentioning

confidence: 99%

See 4 more Smart Citations

Sex effects on neurodevelopmental outcomes of innate immune activation during prenatal and neonatal life

Rana

Aavani

Pittman

2012

Hormones and Behavior

View full text Add to dashboard Cite

Humans are exposed to potentially harmful agents (bacteria, viruses, toxins) throughout our lifespan; the consequences of such exposure can alter central nervous system development. Exposure to immunogens during pregnancy increases the risk of developing neurological disorders such as schizophrenia and autism. Further, sex hormones, such as estrogen, have strong modulatory effects on immune function and have also been implicated in the development of neuropathologies (e.g., schizophrenia and depression). Similarly, animal studies have demonstrated that immunogen exposure in utero or during the neonatal period, at a time when the brain is undergoing maturation, can induce changes in learning and memory, as well as dopaminemediated behaviors in a sex-specific manner. Literature that covers the effects of immunogens on innate immune activation and ultimately the development of the adult brain and behavior is riddled with contradictory findings, and the addition of sex as a factor only adds to the complexity. This review provides evidence that innate immune activation during critical periods of development may have effects on the adult brain in a sex-specific manner. Issues regarding sex bias in research as well as variability in animal models of immune function are discussed.

show abstract

Section: Learning and Memorymentioning

confidence: 87%

Section: Learning and Memorymentioning

confidence: 87%

Section: Methodological Considerationsmentioning

confidence: 99%

Section: Learning and Memorymentioning

confidence: 99%

Section: Learning and Memorymentioning

confidence: 99%

See 3 more Smart Citations

Sex effects on neurodevelopmental outcomes of innate immune activation during prenatal and neonatal life

Rana

Aavani

Pittman

2012

Hormones and Behavior

View full text Add to dashboard Cite

show abstract

Impact of maternal immune activation on dendritic spine development

Pekala

Doliwa

Kalita

2021

Developmental Neurobiology

View full text Add to dashboard Cite

Dendritic spines are small dendritic protrusions that harbor most excitatory synapses in the brain. The proper generation and maturation of dendritic spines are crucial for the regulation of synaptic transmission and formation of neuronal circuits.Abnormalities in dendritic spine density and morphology are common pathologies in autism and schizophrenia. According to epidemiological studies, one risk factor for these neurodevelopmental disorders is maternal infection during pregnancy. This review discusses spine alterations in animal models of maternal immune activation in the context of neurodevelopmental disorders. We describe potential mechanisms that might be responsible for prenatal infection-induced changes in the dendritic spine phenotype and behavior in offspring.

show abstract

Maternal immune activation in neurodevelopmental disorders

Solek

Farooqi

Verly

et al. 2017

Developmental Dynamics

125

View full text Add to dashboard Cite

Converging lines of evidence from basic science and clinical studies suggest a relationship between maternal immune activation (MIA) and neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. The mechanisms through which MIA increases the risk of neurodevelopmental disorders have become a subject of intensive research. This review aims to describe how dysregulation of microglial function and immune mechanisms may link MIA and neurodevelopmental pathologies. We also summarize the current evidence in animal models of MIA. Developmental Dynamics 247:588-619, 2018. © 2017 Wiley Periodicals, Inc.

show abstract

Neurodevelopmental damage after prenatal infection: Role of oxidative stress in the fetal brain

Cited by 122 publications

References 74 publications

Sex effects on neurodevelopmental outcomes of innate immune activation during prenatal and neonatal life

Sex effects on neurodevelopmental outcomes of innate immune activation during prenatal and neonatal life

Impact of maternal immune activation on dendritic spine development

Maternal immune activation in neurodevelopmental disorders

Contact Info

Product

Resources

About