Neurodevelopmental Outcome in Children With Intraventricular Hemorrhage

Futagi, Yasuyuki; Toribe, Yasuhisa; Ogawa, Kazufumi; Suzuki, Yasuhiro

doi:10.1016/j.pediatrneurol.2005.08.011

Cited by 84 publications

(49 citation statements)

References 26 publications

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“…[9,22] CP, a major neurodevelopmental impairment that is generally diagnosed in late childhood, is frequently associated with low BW and IVH. [24,25] The association between CP and ROP has been reported in some studies of children who had very low BW. [26,27] Schmidt et al, discovered that severe ROP has an independent significant influence (p < 0.01) and an add-on OR of 2.9 (95% CI of OR: 2.4-3.5) in the development of CP in infants who had extremely low BW.…”

Section: Discussionmentioning

confidence: 88%

Retinopathy of Prematurity in Neonatal Patients with Birth Weight Greater than 1500 g in Taiwan

Chen¹,

Lien²,

Lai³

et al. 2013

Biomed J

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Section: Discussionmentioning

confidence: 88%

Retinopathy of Prematurity in Neonatal Patients with Birth Weight Greater than 1500 g in Taiwan

Chen¹,

Lien²,

Lai³

et al. 2013

Biomed J

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“…The low survival of grade I patients, consistent with the series of Papile et al [30] of 46 patients, may reflect that these series were described in the late 1970s and diagnosis and management of IVH have changed significantly since then. More recently in 2006, Futagi et al [48] described 575 patients, with grade I patients exhibiting 11% mortality and grade IV patients one of 61%.…”

Section: Discussionmentioning

confidence: 99%

Functional Outcomes among Premature Infants with Intraventricular Hemorrhage

et al. 2009

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Objective: This work evaluated the mortality and functional outcomes of premature infants sustaining intraventricular hemorrhage (IVH). These outcomes were analyzed for their association with IVH severity, development of hydrocephalus and need for ventriculoperitoneal (VP) shunt insertion. Methods: A retrospective review was performed of neonates at the Children’s Hospital of Eastern Ontario who sustained IVH (1989–2005). Logistic regression tested demographic predictors of IVH severity, development of hydrocephalus and mortality. χ² analysis differentiated functional outcomes and mortality by IVH grade, development of hydrocephalus and intervention for cerebrospinal fluid diversion. All analyses used the 0.05 significance level. Results: Data were available for 284 patients with an average follow-up of 5.1 years. These were distributed as grade I (n = 135), grade II (n = 52), grade III (n = 43) and grade IV (n = 54), with lower gestational age and birth weight predicting disease severity. Hydrocephalus developed in 21% of patients, of whom 39% required VP shunt insertion. Overall mortality of 20% depended on IVH grade and was highest for grade IV patients (59%). Functional independence diminished with IVH severity, and patients with hydrocephalus fared worse than those without this sequel. Outcomes of patients developing hydrocephalus were similar whether or not they eventually required VP shunt insertion. Conclusions: This study describes a large cohort of neonatal IVH, describing how disease severity affects mortality and functional outcome. The overall mortality of nearly 1 in 5 patients is primarily of grade IV patients, with no difference between grade II and grade III. Further, patients surviving their hydrocephalus exhibited no worse functional deterioration if they required surgical intervention.

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“…13 However, some recent studies have challenged this notion, 14,15 whereas others 16 continue to support the benign nature of mild PIVH. On the other hand, severe grades of PIVH (grade 3 and 4) are well known to be associated with NDI, but there are significant variations in the reported outcomes, [17][18][19][20] which may lead to variability in counseling of long-term outcomes between practitioners. None of the previous reviews have systematically summarized neurodevelopmental outcomes of different grades of PIVH after adjusting for confounders and effect modifiers.…”

mentioning

confidence: 99%

Periventricular/Intraventricular Hemorrhage and Neurodevelopmental Outcomes: A Meta-analysis

2015

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CONTEXT: Periventricular/intraventricular hemorrhage (PIVH) is a common short-term morbidity in preterm infants, but its long-term neurodevelopmental impact, particularly with mild PIVH, remains unclear. STUDY SELECTION: Studies reporting long-term neurodevelopmental outcomes based on severity of PIVH were included.DATA EXTRACTION: Study characteristics, inclusion/exclusion criteria, exposures, and outcome assessment data extracted independently by 2 coauthors. RESULTS:The pooled unadjusted odds ratios of the primary outcome of death or moderate-severe neurodevelopmental impairment (NDI) were higher with both mild (1.48, 95% CI 1.26-1.73; 2 studies) and severe PIVH (4.72, 4.21-5.31; 3 studies); no studies reported adjusted odds ratios. Among survivors, odds of moderate-severe NDI were higher with mild and severe PIVH in both unadjusted (1.75, 1.40-2.20; 3 studies; 3.36, 3.06-3.68; 5 studies) and adjusted (1.39, 1.09-1.77; 3 studies; 2.44, 1.73-3.42; 2 studies) pooled analyses. Adjusted odds of cerebral palsy and cognitive delay were higher with severe but not mild PIVH.LIMITATIONS: Only observational studies were included. Fifteen of 21 included studies had a moderate-high risk of bias.CONCLUSIONS: Mild and severe PIVH are associated with progressively higher odds of death or moderatesevere NDI compared with no PIVH, but no studies adjusted for confounders. Among survivors, mild PIVH was associated with higher odds of moderate-severe NDI compared with no PIVH.

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Neurodevelopmental Outcome in Children With Intraventricular Hemorrhage

Cited by 84 publications

References 26 publications

Retinopathy of Prematurity in Neonatal Patients with Birth Weight Greater than 1500 g in Taiwan

Retinopathy of Prematurity in Neonatal Patients with Birth Weight Greater than 1500 g in Taiwan

Functional Outcomes among Premature Infants with Intraventricular Hemorrhage

Periventricular/Intraventricular Hemorrhage and Neurodevelopmental Outcomes: A Meta-analysis

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