Neurodevelopmental outcome of preterm very low birth weight infants admitted to an Italian tertiary center over an 11-year period

Longo, Stefania; Caporali, Camilla; Pisoni, Camilla; Borghesi, A.; Perotti, Gianfranco; Tritto, Giovanna; Olivieri, Ivana; Piana, Roberta La; Tonduti, Davide; Decio, Alice; Ariaudo, Giada; Spairani, Silvia; Naboni, Cecilia; Gardella, Barbara; Spinillo, Arsenio; Manzoni, Federica; Tinelli, Carmine; Stronati, Mauro; Orcesi, Simona

doi:10.1038/s41598-021-95864-0

Cited by 15 publications

(12 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings that both a low BW and being SGA are associated with NDI at both 2-and 5-years CA in BPD infants are in line with studies in the general preterm population, showing that intrauterine growth restriction contributes to the risk for having a lower BSID-III score [14,15]. This association probably results from abnormal brain development due to suboptimal environmental conditions during pregnancy such as hypoxemia, reduced blood flow, and malnutrition [16].…”

Section: Discussionsupporting

confidence: 90%

“…Male preterm infants with BPD had a three-fold increased risk for NDI at 5-years CA, compared to their female peers. In an Italian cohort study, a comparable increased risk for male infants was seen at 2-years CA [14]. Gender differences in neurodevelopmental outcomes have been described before and may be caused by unmeasured biological variables likely to be caused by genetic and hormonal factors [17].…”

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Risk Factors for Neurodevelopmental Impairment at 2- and 5-Years Corrected Age in Preterm Infants with Established Bronchopulmonary Dysplasia

Katz,

van Kaam,

Mugie

et al. 2023

Neonatology

View full text Add to dashboard Cite

Introduction: The objective of this study was to identify risk factors for neurodevelopmental impairment (NDI) at 2- and 5-years corrected age (CA) in a cohort of preterm infants with established bronchopulmonary dysplasia (BPD). Methods: This single-center retrospective cohort study included infants born between 2009 and 2016 at a gestational age (GA) <30 weeks with moderate or severe BPD at 36 weeks’ postmenstrual age. Perinatal characteristics, (social) demographics, and comorbidities were collected from the electronic patient records. Odds ratios for NDI were calculated with univariate and multivariate logistic regression analyses adjusting for potential confounders. Results: Of the 602 eligible infants, 123 infants were diagnosed with BPD. NDI was present in 30.3% and 56.1% at 2- and 5-years CA, respectively. The only independent risk factors associated with NDI in the multivariate analyses were birthweight (adjusted odds ratio [aOR] 0.74, 95% CI 0.57–0.95; aOR 0.70, 95% CI 0.54–0.91, respectively), small for GA (SGA) (aOR 3.25, 95% CI 1.09–9.61; aOR 5.44, 95% CI 1.62–18.2, respectively) at both time points, and male gender at 5-years CA (OR 2.49, 95% CI 1.11–5.57). Conclusion: Birthweight and SGA are independent risk factors for NDI at 2- and 5-years CA and male gender at 5-years CA in preterm infants with BPD. In contrast, well-known other risk factors for NDI in the general population of preterm infants, such as GA, maternal education, and neonatal comorbidities were not independently associated with NDI.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 90%

Risk Factors for Neurodevelopmental Impairment at 2- and 5-Years Corrected Age in Preterm Infants with Established Bronchopulmonary Dysplasia

Katz,

van Kaam,

Mugie

et al. 2023

Neonatology

View full text Add to dashboard Cite

show abstract

“…Study also proved that the LBW, with premature birth (< 37 week), intrauterine growth restriction (IUGR) and other genetic factors may develop cardiovascular and renal diseases 41 . Premature birth and LBW infants are on higher risk of developing genetic congenital outcome 42 .…”

Section: Discussionmentioning

confidence: 99%

Impact of children born with low birth weight on stunting and wasting in Sindh province of Pakistan: a propensity score matching approach

Abbas

Kumar

Mahmood³

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Low Birth Weight (LBW) is considered as a major public health issue and leading cause of neonatal death. Almost one in four newborns are reported as underweight in Pakistan. Children born with low birth weight are highly vulnerable to develop diseases and death and/or remain undernourished (i.e., stunted and wasted). This study determines the LBW newborns are more prone to develop stunting and wasting in province of Sindh, Pakistan. Moreover, regression-based estimation of the impact of LBW on the child health outcomes of under five years of age, may be prone to selection bias because of the nature of non-experimental data set, thus, propensity score matching methods are used in this study. Data for this study was used from Multiple Indicators Cluster Survey (MICS-2014). MICS is a two-stage, stratified cluster sampling household level data covering urban and rural areas and consists of 19,500 households from five administrative divisions and 28 districts of Sindh province of Pakistan. The total sample size of children less than five years of age after cleaning the data are 7781, of which 2095 are LBW having birth weight categorized as “smaller than average and very small” and 5686 are normal birth weight (NBW) having birth weight very large, larger than average, and average. This study employed propensity score matching (PSM) regression methods to understand whether the children born as low birth weight are more prone to stunting and wasting and/or both. In province of Sindh, moderate wasting children under five years were 21%, severe wasting 6% and both wasting and stunting 10%. The propensity score results are shown significant in all groups. Specifically, all four types of PSM methods confirm a significant difference in the potential outcome variables—meaning that a child born with LBW has a significant adverse effect on the potential child health outcome variables (stunting, wasting and both). Thus, the propensity score matching findings confirm a significant and adverse effect of LBW on potential health outcomes of under five children. Similarly, low birth weight children are significantly more likely to be moderately wasted (OR = 1.5, CI = 1.3–1.6) and severely wasted (OR = 1.6, CI = 1.3–2.0) and both (stunted and wasted, OR = 2.0, CI = 1.7–2.3) as compared to children with normal birth weight. Male children, if born with low birth weight, are significantly more likely to be moderately wasted (OR = 1.3, CI = 1.1–1.5) and both (wasted and stunted, OR = 1.3, CI = 1.1–1.5) than girls. This large data analysis finding proved that the LBW newborns are on higher risk to develop wasting and stunting in Pakistan.

show abstract

“…Preterm born infants are at a higher risk for adverse neurodevelopmental outcomes at 2 years of age [ 28 ], school age and during adolescence [ 29 , 30 ] compared to infants born at term. Studies examining prolonged apnea, as occurs during apnea of prematurity, have suggested that the resultant hypoxia is associated with an increased risk for neurodevelopmental impairment [ 5 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Developmental consequences of short apneas and periodic breathing in preterm infants

Yee,

Siriwardhana,

Nixson

et al. 2023

J Perinatol

View full text Add to dashboard Cite

Objective We investigated the relationship between respiratory events experienced before and after hospital discharge and developmental outcomes at 6 months corrected age (CA). Study design Preterm infants born between 28–32 weeks gestational age (GA) were studied at 32–36 weeks postmenstrual age (PMA), 36–40 weeks PMA, 3- and 6-months CA. Percentage total sleep time (%TST) with respiratory events (isolated apneas, sequential apneas and periodic breathing (PB)) at each study was calculated. Stepwise multiple linear regressions determined significant predictors of developmental outcomes at 6 months. Result %TST with respiratory events at term were significant predictors of language (R2 = 0.165, β = −0.416) and motor (R2 = 0.180, β = −0.485) composite scores of the Bayley Scales of Infant Development at 6 months, independent of GA, birth weight and sex. Conclusions In clinically stable very preterm infants at term equivalent age, time spent having respiratory events, was related to a reduction in language and motor outcomes at 6 months.

show abstract

Neurodevelopmental outcome of preterm very low birth weight infants admitted to an Italian tertiary center over an 11-year period

Cited by 15 publications

References 56 publications

Risk Factors for Neurodevelopmental Impairment at 2- and 5-Years Corrected Age in Preterm Infants with Established Bronchopulmonary Dysplasia

Risk Factors for Neurodevelopmental Impairment at 2- and 5-Years Corrected Age in Preterm Infants with Established Bronchopulmonary Dysplasia

Impact of children born with low birth weight on stunting and wasting in Sindh province of Pakistan: a propensity score matching approach

Developmental consequences of short apneas and periodic breathing in preterm infants

Contact Info

Product

Resources

About